Results 111 to 120 of about 17,975 (276)

Progress of Enantioselective Nitrile Biotransformations in Organic Synthesis

CHIMIA, 2009
Recent progress of enantioselective biotransformations of nitriles including various functionalized nitriles, ?-hydroxy and ?-amino nitriles, oxirane- and aziridine-containing carbonitriles is summarized in this short review article.
Mei-Xiang Wang
doaj   +1 more source

Cover Picture: Application of Regio‐ and Stereoselective Functional Group Transformations of Chiral Aziridine‐2‐carboxylates (Asian J. Org. Chem. 10/2014) [PDF]

, 2014
Hyun‐Joon Ha, Jaehoon Jung, Won Koo Lee   +2 more
openalex   +1 more source

Metal-free one-pot synthesis of 2-substituted and 2,3-disubstituted morpholines from aziridines

Beilstein Journal of Organic Chemistry, 2015
The metal-free synthesis of 2-substituted and 2,3-disubstituted morpholines through a one-pot strategy is described. A simple and inexpensive ammonium persulfate salt enables the reaction of aziridines with halogenated alcohols to proceed via an SN2-type
Hongnan Sun, Binbin Huang, Run Lin, Chao Yang, Wujiong Xia   +4 more
doaj   +1 more source

2-[3-(Aziridin-1-yl)-2-hydroxypropyl]-5,5-dimethyl-2,5-dihydro-4H-benzo[e]isoindol-4-one (Cytotoxic Oxonaphthalene-Pyrroles, Part III)

Molbank, 2012
An hydroxypropyl-aziridine-containing side chain is attached to an oxonaphthalene-annelated pyrrole in expectation of DNA alkylating properties. The cytotoxicity is evaluated against two cell lines, KB-31 and KB-8511, respectively.
Christiane Puschmann, Helmut Spreitzer
doaj   +1 more source

Biocatalytic One-Carbon Ring Expansion of Aziridines to Azetidines via a Highly Enantioselective [1,2]-Stevens Rearrangement [PDF]

, 2021
David C. Miller, Ravi Lal, Luca Marchetti, Frances H. Arnold   +3 more
openalex   +1 more source

Palladium-Catalyzed Fluorinative Bifunctionalization of Aziridines and Azetidines with gem-Difluorocyclopropanes [PDF]

, 2023
Yaxin Zeng, Ying Xia
openalex   +1 more source

Anomalous Nuclear Overhauser Effects in Carbon‐Substituted Aziridines: Scalar Cross‐Relaxation of the First Kind [PDF]

, 2015
Ilya Kuprov, David M. Hodgson, Johannes Kloesges, Christopher I. Pearson, Barbara Odell, Timothy D. W. Claridge   +5 more
openalex   +1 more source

Secondary 3‐Chloropiperidines: Powerful Alkylating Agents

ChemistryOpen
In previous works, we demonstrated that tertiary 3‐chloropiperidines are potent chemotherapeutics, alkylating the DNA through the formation of bicyclic aziridinium ions. Herein, we report the synthesis of novel secondary 3‐chloropiperidine analogues. The
Mats Georg, Dr. Lina Alexandra Laping, Veronica Billo, Prof. Dr. Barbara Gatto, Prof. Dr. Peter Friedhoff, Prof. Dr. Richard Göttlich   +5 more
doaj   +1 more source

Nitrene Transfer Catalyzed by a Non-Heme Iron Enzyme and Enhanced by Non-Native Small-Molecule Ligands [PDF]

, 2019
Transition-metal catalysis is a powerful tool for the construction of chemical bonds. Here we show that Pseudomonas savastanoi ethylene-forming enzyme, a non-heme iron enzyme, can catalyze olefin aziridination and nitrene C–H insertion, and that these ...
Arnold, Frances H., Goldberg, Nathaniel W., Knight, Anders M., Zhang, Ruijie K.   +3 more
core   +1 more source

Synthesis of Mexiletine Analogues from Non-Activated Aziridines

, 2007
Tore Lejon, Truls Ingebrigtsen
openalex   +1 more source