Results 101 to 110 of about 6,339,291 (274)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Ordered Dissipative Structures in Exciton Systems in Semiconductor Quantum Wells
Symmetry, Integrability and Geometry: Methods and Applications, 2006 A phenomenological theory of exciton condensation in conditions of inhomogeneous excitation is proposed. The theory is applied to the study of the development of an exciton luminescence ring and the ring fragmentation at macroscopical distances from the ...
Andrey A. Chernyuk, Volodymyr I. Sugakov
doaj
Molecular Topology Index of a Zero Divisor Graph on a Ring of Integers Modulo Prime Power Order
Contemporary Mathematics and Applications (ConMathA)In chemistry, graph theory has been widely utilized to address molecular problems, with numerous applications in graph theory and ring theory within this field.
Didit Satriawan +4 more
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Density of Tree-Ring Grids in Western North America
, 1982 The separating distance over which tree-ring chronologies are significantly correlated is investigated. Any chronology occuring within a radius of 161 km of another is estimated to contain at least half of the common variance occurring at zero separating
Cropper, John Philip, Fritts, Harold C.
core +3 more sources
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Journal of High Energy PhysicsWe further investigate the 3d gauged linear sigma model (GLSM)/ quantum K-theory correspondence for partial flag manifolds X ≡ Fl(k; n). This is a 3d uplift of the 2d GLSM/quantum cohomology correspondence with the 3d theory compactified on ℝ 2 × S β 1 $$
Zhihao Duan, Osama Khlaif, Hao Zou
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PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source