Results 51 to 60 of about 2,715,425 (309)

Mitigating Blast Hazards: Experimental Evaluation of Anti-Shatter Films and Catcher-Cable Systems on Conventional Windows

Buildings
In light of terrorist attacks and accidents, the need for structural protection against explosive events has increased significantly in recent decades. Conventional unprotected windows pose a particularly high risk of injury to building occupants due to ...
Matthias Andrae, Jan Dirk van der Woerd, Matthias Wagner, Achim Pietzsch, Norbert Gebbeken   +4 more
doaj   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

SABTR: semantic analysis-based tourism recommendation

Frontiers in Physics
Online tourism spot recommendations, as a key component of tourism services, aim to present travel options that align with users’ personal preferences. However, current recommendation systems often underperform due to the sparsity of tourism data and the
Jiao Li, Jiao Li, Huajian Xue, Huajian Xue, Qigui Tang, Hailiang Wang, Tieliang Gao, Tieliang Gao   +7 more
doaj   +1 more source

Computational Aspects of Dam Risk Analysis: Findings and Challenges

Engineering, 2016
In recent years, risk analysis techniques have proved to be a useful tool to inform dam safety management. This paper summarizes the outcomes of three themes related to dam risk analysis discussed in the Benchmark Workshops organized by the International
Ignacio Escuder-Bueno, Guido Mazzà, Adrián Morales-Torres, Jesica T. Castillo-Rodríguez   +3 more
doaj   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Fire Risk Analysis and Evaluation of Rescue Facilities in the Engineering Laboratory Building [PDF]

, 2022
Dani Nugroho Saputro, Eni Rahmawati
openalex   +1 more source

Behavioral Aspects of Population Mobility Following a CBRN Event and Their Implications for Economic Consequence Analysis

International Journal of Disaster Risk Science
Chemical, biological, radiological, and nuclear (CBRN) events can take a catastrophic toll on human life, the environment, and the economy. This article first presents the beginnings of a framework for the analysis of behavioral aspects of population ...
Adam Rose, Bess Djavadi
doaj   +1 more source

Levee System Reliability Modeling: The Length Effect and Bayesian Updating

Safety, 2020
In levee system reliability, the length effect is the term given to the phenomenon that the longer the levee, the higher the probability that it will have a weak spot and fail.
Kathryn Roscoe, Anca Hanea, Ruben Jongejan, Ton Vrouwenvelder   +3 more
doaj   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source