Results 71 to 80 of about 6,445,882 (303)

Recognition of Building Structural Types Using Multisource Remote Sensing Data and Prior Knowledge

Remote Sensing
Accurate identification of building structural types (BSTs) is essential for seismic vulnerability assessment and disaster risk management. Traditional field survey methods are constrained by high costs, low efficiency, and limited scalability.
Lili Wang, Jidong Wu, Yachun He, Youtian Yang   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Spatiotemporal Analyses of High-Resolution Precipitation Ensemble Simulations in the Chinese Mainland Based on Quantile Mapping (QM) Bias Correction and Bayesian Model Averaging (BMA) Methods for CMIP6 Models

Atmosphere
Fluctuations in precipitation usually affect the ecological environment and human socioeconomics through events such as floods and droughts, resulting in substantial economic losses. The high-resolution models in the Coupled Model Intercomparison Project
Hao Meng, Zhenhua Di, Wenjuan Zhang, Huiying Sun, Xinling Tian, Xurui Wang, Meixia Xie, Yufu Li   +7 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Increasing Future Global Compound Heat Flash Droughts and Socioeconomic Exposure

Earth's Future
Compound heat flash droughts (CHFDs) can severely impact human society. However, the spatiotemporal evolution and socioeconomic impacts under future scenarios remain poorly understood.
You Li, Ming Wang, Bohao Li, Linmei Zhuang, Kai Liu   +4 more
doaj   +1 more source

Nitrogen and Water Additions Affect N₂O Dynamics in Temperate Steppe by Regulating Soil Matrix and Microbial Abundance

Agriculture
Elucidating the effects of nitrogen and water addition on N2O dynamics is critical, as N2O is a key driver of climate change (including nitrogen deposition and shifting precipitation patterns) and stratospheric ozone depletion.
Siyu Ren, Yinghui Liu, Pei He, Yihe Zhao, Chang Wang   +4 more
doaj   +1 more source

Corporate Governance, Opaque Bank Activities, and Risk/Return Efficiency: Pre- and Post-Crisis Evidence from Turkey [PDF]

Does better corporate governance unambiguously improve the risk/return efficiency of banks? Or does either a re-orientation of banks' revenue mix towards more opaque products, an economic downturn, or tighter supervision create off-setting or reinforcing
Schoors, K., De Jonghe, O.G., Disli, M.
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Upscaling of Soil Moisture over Highly Heterogeneous Surfaces and Validation of SMAP Product

Land
Soil moisture (SM) is a critical component of the global water cycle, profoundly influencing carbon fluxes and energy exchanges between the land surface and the atmosphere.
Jiakai Qin, Zhongli Zhu, Qingxia Wu, Julong Ma, Shaomin Liu, Linna Chai, Ziwei Xu   +6 more
doaj   +1 more source