Results 101 to 110 of about 4,631,625 (311)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Disaster Risk Reduction Audits and BIM for Resilient Highway Infrastructure: A Proactive Assessment Framework

Buildings
Highway infrastructure faces growing exposure to natural hazards, necessitating more proactive and data-driven risk mitigation strategies. This study explores the integration of Disaster Risk Reduction Audits (DRRAs) into the lifecycle of highway ...
Seung-Jun Lee, Hong-Sik Yun, Ji-Sung Kim, Hwan-Dong Byun, Sang-Hoon Lee   +4 more
doaj   +1 more source

Flexibility and Resilience in Corporate Decision Making: A New Sustainability-Based Risk Management System in Uncertain Times. [PDF]

Glob J Flex Syst Manag, 2021
Settembre-Blundo D, González-Sánchez R, Medina-Salgado S, García-Muiña FE.   +3 more
europepmc   +1 more source

The Complexities of Financial Risk Management and Systemic Risks [PDF]

Risk-management systems in financial institutions have come under increasing scrutiny in light of the current financial crisis, resulting in calls for improvements and an increased role for regulators.
Frank Milne
core  

Management of Phytophthora cinnamomi for biodiversity conservation in Australia: Part 2. National best practice guidelines [PDF]

, 2005
Disease in natural ecosystems of Australia, caused by the introduced plant pathogen Phytophthora cinnamomi, is listed as a key threatening process under the Environment Protection and Biodiversity Conservation Act 1999 (EPBC Act).
Hardy, G.E.St.J., Howard, K., O'Gara, E., Wilson, B.   +3 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

XAI Helps in Storm Surge Forecasts: A Case Study for the Southeastern Chinese Coasts

Journal of Marine Science and Engineering
Storm surge forecasting presents a significant challenge for coastal resilience, particularly in typhoon-prone regions such as southeastern China, where compound flooding events lead to substantial socioeconomic losses.
Lei Han, Wenfang Lu, Changming Dong
doaj   +1 more source

[Further Development of Maturity Levels of Quality and Risk Management System at the University Hospital Schleswig-Holstein]. [PDF]

Gesundheitswesen, 2023
Soeth E, Hilbert C, Scharffenberg S, Wehkamp K, Rogge A, Kahla-Witzsch H, Freitag-Wolf S, Scholz J, Petzina R.   +8 more
europepmc   +1 more source

Interest rate risk in the French banking system. [PDF]

Although most bank failures and banking problems historically have been attributable to poorly managed exposures to credit risk, inadequate management of interest rate risk can give rise to the same types of problems, as illustrated by the U.S.
Golitin, V., Quémard, J L.
core  

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source