Results 71 to 80 of about 7,974,169 (304)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Risk Prediction [PDF]

Circulation, 2016
Articles, see p 1419 and p 1430 Population aging and improvements in survival after cardiovascular disease have contributed to worldwide increases in the number of patients with established cardiovascular disease. An almost epidemic number of people, >16 million Americans, suffering from ischemic heart disease serves as clear evidence of the ...
openaire   +3 more sources

Climate Risk Assessment - Charleston County, South Carolina

, 2023
As a result of climate change, flood risk is expected to increase throughout Charleston County. The probability of the 100-year rainfall event, a useful indicator of flood risk, will likely triple by the mid 21st century.
Woodwell Climate Research Center - Risk Program, Dusseau, Dominick, Huff, J. Jacob   +2 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Risk Aversion, Beliefs, and Prediction Market Equilibrium [PDF]

Manski [2004] analyzes the relationship between the distribution of traders’ beliefs and the equilibrium price in a prediction market with risk neutral traders.
Steven Gjerstad
core  

Multiethnic polygenic risk scores improve risk prediction in diverse populations [PDF]

, 2017
Methods for genetic risk prediction have been widely investigated in recent years. However, most available training data involves European samples, and it is currently unclear how to accurately predict disease risk in other populations.
Loh, Po Ru, Alkes L. Price, Price, Alkes L, Loh, Po-Ru, Pinidiyapathirage, Janani, Price, Alkes L., null null, Carla Márquez-Luna, Po-Ru Loh, Márquez-Luna, Carla   +9 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Solving forced KdV equation using physics-informed neural networks

Geoscience Letters
Physics-informed neural networks (PINNs) are applied to solve forced-KdV (fKdV) equations and to assess their capability for nonlinear wave dynamics under external forcing. We first validate the solver in analytically tractable forced-KdV benchmarks with
Lei Han, Changming Dong, Wanchen Cui, Huarong Xie, Weijun Zhu   +4 more
doaj   +1 more source

Improvement of Risk Prediction After Transcatheter Aortic Valve Replacement by Combining Frailty With Conventional Risk Scores. [PDF]

, 2018
OBJECTIVES This study sought to evaluate whether frailty improves mortality prediction in combination with the conventional scores. BACKGROUND European System for Cardiac Operative Risk Evaluation (EuroSCORE) or Society of Thoracic Surgeons (STS)
Thierry Carrel, Andreas E. Stuck, Windecker, Stephan, Stuck, Andreas E, Schoenenberger, Andreas W, Peter Wenaweser, Andreas W. Schoenenberger, Moser, André, Wenaweser, Peter, Stortecky, Stefan, Carrel, Thierry, André Moser, Stephan Windecker, Bertschi, Dominic, Dominic Bertschi, Stefan Stortecky, Schoenenberger AW, Windecker S, Wenaweser P, Carrel T, Moser A, Bertschi D, Stuck AE, Stortecky S   +23 more
core   +1 more source