Results 71 to 80 of about 7,559,776 (293)

Influence of various criteria on identifying the springtime tropospheric ozone depletion events (ODEs)at Utqiaġvik, Arctic [PDF]

open access: yesAtmospheric Chemistry and Physics
Tropospheric ozone depletion events (ODEs) occurring in the Arctic spring are a unique photochemical phenomenon in which the boundary layer ozone drops rapidly to near-zero levels.
X. Zhu   +5 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Investigating the Impact of Species Diversity on the Carbon Sequestration Potential of Forest Vegetation Based on Solar-Induced Chlorophyll Fluorescence

open access: yesRemote Sensing
Forest species diversity plays a critical role in regulating vegetation carbon sequestration potential. However, the mechanisms by which species diversity influences carbon dynamics under varying forest conditions are not yet fully understood.
Xue-Meng Wang, Lang-Qin Hua, Guo-Yi Zhou
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Multi-Source Remote Sensing-Constrained Evaluation of CMAQ Aerosol Optical Depth over Major Urban Clusters in China

open access: yesRemote Sensing
Aerosol optical depth (AOD) is a key indicator for quantifying aerosol radiative effects and evaluating air quality. However, atmospheric chemical transport models often exhibit systematic AOD biases, and model capability for column-integrated optical ...
Zhaoyang Peng   +6 more
doaj   +1 more source

Risk Assessment and Predictive Microbiology

open access: yesJournal of Food Protection, 1996
The need and desirability of being able to perform quantitative microbial risk assessments for food processing and preparation operations has been discussed extensively for the past several years. However, there has been little application of this approach in large part due to the need to account for the changes in bacterial populations as a result of ...
Robert L, Buchanan, Richard C, Whiting
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Multiethnic polygenic risk scores improve risk prediction in diverse populations [PDF]

open access: yes, 2017
Methods for genetic risk prediction have been widely investigated in recent years. However, most available training data involves European samples, and it is currently unclear how to accurately predict disease risk in other populations.
Loh, Po Ru   +9 more
core   +1 more source

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