Results 81 to 90 of about 7,559,776 (293)

Assessment of a New Cloud Fraction Scheme for Precipitation Simulations Over the Tibetan Plateau

Advances in Meteorology
Accurate precipitation simulation over the Tibetan Plateau (TP) remains a major challenge for numerical weather forecasting due to the region’s complex terrain and highly heterogeneous convective processes.
Boyu Liao, Shuzhou Wang
doaj   +1 more source

Simultaneous Remote Sensing of HD¹⁶O/H₂¹⁶O Profile Using Differential Absorption Lidar: A Feasibility Analysis

Remote Sensing
A novel multi-wavelength differential absorption lidar operating at 1.5 μm band is proposed and theoretically analyzed for simultaneous remote sensing of vertical profiles of H216O, HD16O, and the isotopic ratio δD.
Saifen Yu, Zhen Zhang, Haiyun Xia
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Influence of Snow Redistribution and Melt Pond Schemes on Simulated Sea Ice Thickness During the MOSAiC Expedition

Journal of Marine Science and Engineering
The observations of atmospheric, oceanic, and sea ice data from the Multidisciplinary drifting Observatory for the Study of Arctic Climate (MOSAiC) expedition were used to analyze the influence of snow redistribution and melt-pond processes on the ...
Jiawei Zhao, Yang Lu, Haibo Zhao, Xiaochun Wang, Jiping Liu   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Probabilistic Forecasting Model for Tropical Cyclone Intensity Based on Diffusion Model

Remote Sensing
Reliable forecasting of tropical cyclone (TC) intensity—particularly rapid intensification (RI) events—remains a major challenge in meteorology, largely due to the inherent difficulty of accurately quantifying predictive uncertainty.
Jingjia Luo, Peng Yang, Fan Meng
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Cardiovascular Risk Prediction [PDF]

Circulation Research, 2017
Accurate assessment of cardiovascular risk in the clinical setting is important for appropriate management and counseling of patients and for identification of biological pathways. Classic models, including the Framingham risk score,1 have combined strong correlates of risk, such as age, with modifiable factors, such as blood pressure and lipids, into ...
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source