Results 81 to 90 of about 7,974,169 (304)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Risk Assessment and Predictive Microbiology

Journal of Food Protection, 1996
The need and desirability of being able to perform quantitative microbial risk assessments for food processing and preparation operations has been discussed extensively for the past several years. However, there has been little application of this approach in large part due to the need to account for the changes in bacterial populations as a result of ...
Robert L, Buchanan, Richard C, Whiting
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Investigating the Impact of Species Diversity on the Carbon Sequestration Potential of Forest Vegetation Based on Solar-Induced Chlorophyll Fluorescence

Remote Sensing
Forest species diversity plays a critical role in regulating vegetation carbon sequestration potential. However, the mechanisms by which species diversity influences carbon dynamics under varying forest conditions are not yet fully understood.
Xue-Meng Wang, Lang-Qin Hua, Guo-Yi Zhou
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Influence of various criteria on identifying the springtime tropospheric ozone depletion events (ODEs)at Utqiaġvik, Arctic [PDF]

Atmospheric Chemistry and Physics
Tropospheric ozone depletion events (ODEs) occurring in the Arctic spring are a unique photochemical phenomenon in which the boundary layer ozone drops rapidly to near-zero levels.
X. Zhu, L. Cao, X. Yang, S. Li, J. Wang, T. Zhao   +5 more
doaj   +1 more source

Brain Connectomics Improve the Prediction of High-Risk Depression Profiles in the First Year following Breast Cancer Diagnosis [PDF]

Background. Prediction of high-risk depression trajectories in the first year following breast cancer diagnosis with fMRI-related brain connectomics is unclear. Methods.
Chen, P., Molasiotis, A., Yu, Y.L., Ye, Z.J., Knobf, M.T., Sun, Z., Tang, Y., Tang, X.N., Hu, G.Y., Liang, M. Z., Liu, M.L., Hu, Guang Yun, Liu, Mei Ling, Liang, Mu Zi, Knobf, M. Tish, Tang, Ying, Molassiotis, Alex, Yu, Yuan Liang, Ye, Zeng Jie, Chen, Peng, Tang, Xiao Na, Sun, Zhe   +21 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Multi-Source Remote Sensing-Constrained Evaluation of CMAQ Aerosol Optical Depth over Major Urban Clusters in China

Remote Sensing
Aerosol optical depth (AOD) is a key indicator for quantifying aerosol radiative effects and evaluating air quality. However, atmospheric chemical transport models often exhibit systematic AOD biases, and model capability for column-integrated optical ...
Zhaoyang Peng, Yikun Yang, Yuzhi Jin, Bin Wang, Zhouyang Zhang, Ting Pan, Zeyuan Tian   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source