Results 101 to 110 of about 4,391,095 (303)

ADHD-associated risk taking is linked to exaggerated views of the benefits of positive outcomes [PDF]

open access: yes, 2016
Attention deficit and hyperactivity disorder (ADHD) is often assumed to be associated with increased engagement in risk-taking behaviors. The current study sought to understand the mental processes underlying this association using a theory-driven ...
Aloni, Hamutal   +4 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Delegated Portfolio Management and Risk Taking Behavior [PDF]

open access: yes
Standard models of moral hazard predict a negative relationship between risk and incentives; however empirical studies on mutual funds present mixed results.
Benjamin Miranda Tabak   +2 more
core  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Monetary Policy and Excessive Bank Risk Taking [PDF]

open access: yes
If monetary policy is to aim at financial stability, how would it change? To analyze this question, this paper develops a general-form model with endogenous bank risk profiles.
Agur, I., Demertzis, M.
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

The Neural Basis of Financial Risk Taking [PDF]

open access: yes
Investors systematically deviate from rationality when making financial decisions, yet the mechanisms responsible for these deviations have not been identified.
Brian Knutson, Camelia Kuhnen
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Risk-taking Behaviours among Adolescents (13–19 Years) in Jibannagar, Chuadanga, Bangladesh: A Cross-sectional Study

open access: yesPreventive Medicine: Research & Reviews
Background: Adolescent risk-taking behaviours are a global public health issue. The study aims to explore the proportion, types and factors influencing risk-taking behaviours among adolescents in Jibannagar Upazila, Chuadanga.
Md. Habibur Rahman   +5 more
doaj   +1 more source

Risky choice in younger versus older adults: Affective context matters [PDF]

open access: yesJudgment and Decision Making, 2013
Earlier frameworks have indicated that older adults tend to experience decline in their deliberative decisional capacity, while their affective abilities tend to remain intact (Peters, Hess, Vastfjall, and Auman, 2007).
Yumi Huang   +3 more
doaj  

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