Results 191 to 200 of about 51,631 (281)

Older adults select different but not simpler strategies than younger adults in risky choice. [PDF]

PLoS Comput Biol
Bolenz F, Pachur T.
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Multiple timescales of temporal context in risky choice: Behavioral identification and relationships to physiological arousal. [PDF]

PLoS One
Brooks HR, Sokol-Hessner P.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Methamphetamine increases risky choice in rats, but only when magnitude and probability of reinforcement are manipulated within a session. [PDF]

Pharmacol Biochem Behav
Yates JR, Adhikari S, Bako RE, Berling KL, Broderick MR, Mains R, Zwick B.   +6 more
europepmc   +1 more source

Gambling disorder is associated with reduced sensitivity to expected value during risky choice. [PDF]

J Behav Addict, 2020
Limbrick-Oldfield EH, Cherkasova MV, Kennedy D, Goshko CB, Griffin D, Barton JJS, Clark L.   +6 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Most rats prefer gambling opportunities featuring win-paired cues that drive risky choice: Synergistic interactions between choice of and choice during the cued rat gambling task. [PDF]

Brain Neurosci Adv
Hales CA, Hrelja KM, Ansary S, Chong E, Russell B, Winstanley CA.   +5 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

SK609, a novel dopamine D3 receptor agonist and norepinephrine transporter blocker with putative pro-cognitive actions, does not induce psychostimulant-like increases in risky choice during probabilistic discounting. [PDF]

Psychopharmacology (Berl)
Knapp CP, Fallon B, Kortagere S, Waterhouse BD, Floresco SB, Navarra RL.   +5 more
europepmc   +1 more source