Results 1 to 10 of about 12,478 (189)

Glycoprotein Ib activation by thrombin stimulates the energy metabolism in human platelets. [PDF]

PLoS ONE, 2017
Thrombin-induced platelet activation requires substantial amounts of ATP. However, the specific contribution of each ATP-generating pathway i.e., oxidative phosphorylation (OxPhos) versus glycolysis and the biochemical mechanisms involved in the thrombin-
Norma Corona de la Peña, Manuel Gutiérrez-Aguilar, Ileana Hernández-Reséndiz, Álvaro Marín-Hernández, Sara Rodríguez-Enríquez   +4 more
doaj   +5 more sources

Antibiotic resistance mechanisms inform discovery: identification and characterization of a novel amycolatopsis strain producing ristocetin. [PDF]

Antimicrobial Agents and Chemotherapy, 2014
Discovering new antibiotics is a major scientific challenge, made increasingly urgent by the continued development of resistance in bacterial pathogens.
Cheng, Jinhua, Hong, Hee-Jeon, Kwun, Min Jung, Suh, Joo-Won, Truman, Andrew W, Yang, Seung Hwan   +5 more
core   +3 more sources

Draft Genome Sequence of Amycolatopsis lurida NRRL 2430, Producer of the Glycopeptide Family Antibiotic Ristocetin. [PDF]

Genome Announcements, 2014
We report here the first draft genome sequence for Amycolatopsis lurida NRRL 2430, the producer of the glycopeptide antibiotic ristocetin. The 9-Mbp genome is predicted to harbor 8,143 genes, including those belonging to the ristocetin biosynthesis ...
Hong, Hee-Jeon, Kwun, Min Jung
core   +4 more sources

Ristocetin-induced platelet aggregation for monitoring of bleeding tendency in CLL treated with ibrutinib

Leukemia, 2016
Bleeding because of impaired platelet function is a major side effect of the Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib. We quantitatively assessed ristocetin-induced platelet aggregation (RIPA) in 64 patients with chronic lymphocytic leukemia ...
Alexander Egle
exaly   +2 more sources

Perhaps it's not the platelet: Ristocetin uncovers the potential role of von Willebrand factor in impaired platelet aggregation following traumatic brain injury

Journal of Trauma and Acute Care Surgery, 2018
BACKGROUND Injury to the blood-brain barrier exposes endothelium rich in von Willebrand factor (vWF), which may play a role in altered platelet aggregation following traumatic brain injury (TBI).
Lucy Z Kornblith, Anamaria J Robles
exaly   +2 more sources

Thrombocytosis and bleeding in myeloproliferative neoplasms: exploring clinical diversity and risk of acquired von Willebrand syndrome—insights from a UK center [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: Myeloproliferative neoplasms (MPNs) represent a group of blood disorders characterized by myeloid cell proliferation and an associated increased risk of thrombosis and bleeding.
Giulia Simini, Andrew Innes, Saravanan Vinayagam, Golzar Mobayen, Nilanthi Karawitage, Simone Claudiani, Zain Odho, Mike Laffan, Deepa J. Arachchillage   +8 more
doaj   +2 more sources

A rare case of acquired von Willebrand syndrome type 2B: diagnosis, treatment, and underlying pathophysiology [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: Acquired von Willebrand syndrome (AVWS) is a rare bleeding disorder that usually mimics type 1 or 2A von Willebrand disease (VWD). Key Clinical Question: Can AVWS mimic the phenotype of type 2B VWD?
Simon Jaouen, Fanny Mingant, Brigitte Pan-Petesch, Eric Lippert, Emmanuelle Jeanpierre, Hubert Galinat   +5 more
doaj   +2 more sources

Common VWF exon 28 polymorphisms in African Americans affecting the VWF activity assay by ristocetin cofactor

Blood, 2010
Veronica H Flood, B R Branchford
exaly   +2 more sources

Differential sensitivity of von Willebrand factor (VWF) ‘activity’ assays to large and small VWF molecular weight forms: a cross‐laboratory study comparing ristocetin cofactor, collagen‐binding and mAb‐based assays

Journal of Thrombosis and Haemostasis, 2012
E. J. Favaloro, R. Bonar, K. Chapman, M. Meiring, D. F. Adcock   +4 more
exaly   +2 more sources

Limitations of the ristocetin cofactor assay in measurement of von Willebrand factor function

Journal of Thrombosis and Haemostasis, 2009
V. Flood, Kenneth D. Friedman, J. C. Gill, J. C. Gill, P. A. Morateck, Jeffrey S. Wren, J. P. Scott, J. P. Scott, Robert R. Montgomery, Robert R. Montgomery   +9 more
exaly   +2 more sources