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Synthetic studies towards Ristocetin A and related compounds using arene-ruthenium chemistry
, 1995 Kieseung Lee
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Total Synthesis of the Ristocetin Aglycon
Journal of the American Chemical Society, 2004The first total synthesis of the ristocetin aglycon is described employing a modular and highly convergent strategy. An effective 12-step (12% overall) synthesis of the ABCD ring system 3 from its amino acid subunits sequentially features an intramolecular aromatic nucleophilic substitution reaction for formation of the diaryl ether and closure of the ...
Dale L Boger
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Ristocetin and Ristocetin-Neomycin for Preoperative Preparation of the Colon
Archives of Surgery, 1958Interest in antibacterial agents for preoperative preparation of the bowel has stimulated us to evaluate new agents by standardized techniques which permit comparisons of different agents.1,2,7Ristocetin, isolated from the actinomycete Nocardia lurida recovered from a Colorado soil sample, has been reported to be particularly effective against ...
I, COHN, A B, LONGACRE
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On the interaction between ristocetin and the ristocetin cofactor (RCOF)
Thrombosis Research, 1977Abstract The induction of platelet aggregation by the antibiotic ristocet in requires the participation of a plasma factor, Ristocetin CoFactor (RCoF), which is deficient in patients with vonWillebrand's disease. Although it has been shown that ristocetin precipitates fibrinogen, its interaction with RCoF remains obscure.
M, Floyd, W, Burns, D, Green
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Evaluation of RistocetinâWillebrand Factor Assay and Ristocetin-induced Platelet Aggregation
American Journal of Clinical Pathology, 1975Normal subjects, patients with various bleeding disorders, and patients with von Willebrand's disease were studied. All patients with von Willebrand's disease had decreased levels of ristocetin-Willebrand factor (range, 0 to 41%) as compared with all other subjects (range, 79 to 202%). Ristocetin-induced platelet aggregation of platelet-rich plasma was
J D, Olson +4 more
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Actions of ristocetin on platelets
American Journal of Hematology, 1976AbstractThe absence of ristocetinâinduced platelet aggregation appears to correlate with the platelet defect in von Willebrand's disease, suggesting that this reaction mimics a physiological process. The effect of ristocetin on plasma and on the residual levels of the von Willebrand factor (vWF), Factor VIII procoagulant activity, and Factor VIII ...
J, Koutts, L, Stott, B G, Firkin
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Ristocetin-induced aggregation of canine platelets
Thrombosis Research, 1980Abstract Both canine plasma and canine platelets have been reported to be unreactive in the ristocetin-induced platelet aggregation reaction that is commonly used to study the platelet-von Willebrand factor interaction. Because canine plasma was recently found to have ristocetin cofactor (RCF) activity with human platelets, we studied the RCF ...
L A, Leis +3 more
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