Results 41 to 50 of about 9,310 (270)
European Journal of Haematology, EarlyView.ABSTRACT Objectives The WIL‐31 study demonstrated efficacy and safety of prophylaxis with the plasma‐derived von Willebrand factor/factor VIII concentrate wilate in von Willebrand disease (VWD) of all types and was the only prospective study with an on‐demand run‐in study as an intra‐individual comparator.
Claudia Djambas Khayat +10 more
wiley +1 more source
Frontiers in Pharmacology, 2019 HD1 and HD22 are two of the most-studied aptamers binding to thrombin exosite I and exosite, respectively. To complete of their pharmacological profiles, the effects of HD1 and HD22 on thrombin-, ristocetin-, and collagen-induced human platelet ...
Katarzyna Derszniak +11 more
doaj +1 more source
Increased plasma von Willebrand factor antigen levels but normal von Willebrand factor cleaving protease (ADAMTS13) activity in preeclampsia. [PDF]
, 2009 The activity of ADAMTS13, the von Willebrand factor (VWF) cleaving protease is low in several conditions, including HELLP (haemolysis, elevated liver enzymes, and low platelet count) syndrome.
Bõze, Tamás +9 more
core +1 more source
Dried plasma retains hemostatic function and thermal stability during Arctic military operations
Transfusion, EarlyView.Abstract Background Dried plasma offers a practical alternative for remote damage control resuscitation, providing hemostatic support and volume replacement. The Arctic presents challenges that necessitate the need for blood‐based resuscitation to extend the “golden hour.” To address this, we evaluated the hemostatic and thermal stability of dried ...
Kanwal Singh +17 more
wiley +1 more source
Effect of alteplase on platelet function and receptor expression
Journal of International Medical Research, 2019 Objective To investigate the role of alteplase, a widely-used thrombolytic drug, in platelet function. Methods Human platelets were incubated with different concentrations of alteplase followed by analysis of platelet aggregation in response to adenosine
Jun Lu +5 more
doaj +1 more source
Functional and molecular characterization of inherited platelet disorders in the Iberian Peninsula: results from a collaborative study [PDF]
, 2014 BACKGROUND: The diagnostic evaluation of inherited platelet disorders (IPDs) is complicated and time-consuming, resulting in a relevant number of undiagnosed and incorrectly classified patients.
Antón, AI +12 more
core +1 more source
Pathogen‐reduced plasma, cryoprecipitate reduced for therapeutic plasma exchange
Transfusion, EarlyView.Abstract Background Therapeutic plasma exchange (TPE) for thrombotic thrombocytopenic purpura (TTP) and auto‐immune disorders involves repeated patient exposure to allogenic plasma with the risk of transfusion‐transmitted infection (TTI).
Florian Tupin +6 more
wiley +1 more source
Clinical and laboratory variability in a cohort of patients diagnosed with type 1 VWD in the United States [PDF]
, 2016 Von Willebrand disease (VWD) is the most common inherited bleeding disorder, and type 1 VWD is the most common VWD variant. Despite its frequency, diagnosis of type 1 VWD remains the subject of much debate.
Abshire, T.C. +24 more
core +1 more source
Biological properties of ristocetin-.PSI.-aglycone.
The Journal of Antibiotics, 1982 Ristocetin-ps-aglycone obtained by acid hydrolysis of ristocetin A, has a substantially greater antimicrobial activity against Gram-positive bacteria than the parent compound. None of the substances are active against Gram-negative bacteria, yeast or fungi.
R V, Nielsen +2 more
openaire +3 more sources
Heyde Syndrome: A Literature Review
Health Science Reports, Volume 9, Issue 2, February 2026.ABSTRACT Background and Aims Heyde syndrome, a triad of anemia from gastrointestinal (GI) bleeding, aortic valve stenosis, and acquired von Willebrand syndrome, primarily affects individuals over 65. Management requires a multidisciplinary approach, including medical therapy, endoscopic intervention, and valve replacement.
Yashika Gupta +12 more
wiley +1 more source