Results 41 to 50 of about 13,243 (286)
Management challenge of a rare concomitant platelet glycoprotein IV/CD36 and IIb/IIIa deficiencies: Case illustration. [PDF]
TransfusionAbstract Introduction/Background Platelet membrane glycoproteins (GPs) serve several functions, the most significant of which is their role in primary hemostasis. Among these, GP IIb/IIIa is the primary fibrinogen receptor and is essential for platelet aggregation.
Sekayan T +8 more
europepmc +2 more sources
Laboratory aspects of von Willebrand disease: test repertoire and options for activity assays and genetic analysis [PDF]
, 2014 The deficiency or abnormal function of von Willebrand factor (VWF) causes von Willebrand disease (VWD), the most frequent inherited bleeding disorder. The laboratory diagnosis of VWD can be difficult as the disease is heterogeneous and an array of assays
Castaman, G., Goodeve, A., Hillarp, A.
core +1 more source
Ristocetin and the thrombin clotting time. [PDF]
Journal of Clinical Pathology, 1978 The addition of the antibiotic ristocetin to plasma accelerated the thrombin clotting time (TCT) in 20 out of 22 subjects. Prior incubation of ristocetin with thrombin or plasma did not alter its effect on the TCT. Ristocetin accelerated clotting greatly at low but not at high levels of thrombin.
R M Lindsay +5 more
openaire +2 more sources
Platelets, 2019 Light transmission aggregometry (LTA) is still considered as the “gold standard” for platelet function assessment but, as acompletely manual technology, it is labour intensive.
V.-E. Bret +7 more
doaj +1 more source
Large-scale purification of factor VIII by affinity chromatography: optimization of process parameters [PDF]
, 1990 The optimization of a new process for the extraction of human coagulation factor VIII (FVIII) from plasma with the tailor-made affinity matrix dimethylaminopropylcarbamylpentyl-Sepharose CL-4B (C3---C5 matrix) is described.
Bantjes, Adriaan +8 more
core +10 more sources
Evaluation of an automated light transmission aggregometry
Platelets, 2017 Light transmission aggregometry (LTA) is the “gold standard” for platelet function assessment, but it is time-consuming and labor intensive. Recently, an automated platelet aggregation method has been developed on a routine coagulation analyzer (Sysmex ...
Li-qin Ling +7 more
doaj +1 more source
BMC Anesthesiology, 2019 Background Hemorrhage and blood loss are still among the main causes of preventable death. Global hemostatic assays are useful point-of-care test (POCT) devices to rapidly detect cumulative effects of plasma factors and platelets on coagulation ...
H.-G. Topf +5 more
doaj +1 more source
Von Willebrand disease type 2B with a novel mutation in the VWF gene
Annals of Saudi Medicine, 2021 We report a 38-year-old woman who presented with a subdural hematoma after minor facial trauma in a stressful situation. The laboratory data showed a subnormal platelet count (166×109/L), VWF:RCo activity was 45% and VWF:Ag was 53% with a VWF:RCo/VWF Ag ...
Mohammed Abdullah Jeraiby +4 more
doaj +1 more source
The functions of the A1A2A3 domains in von Willebrand factor include multimerin 1 binding. [PDF]
, 2016 Multimerin 1 (MMRN1) is a massive, homopolymeric protein that is stored in platelets and endothelial cells for activation-induced release. In vitro, MMRN1 binds to the outer surfaces of activated platelets and endothelial cells, the extracellular matrix (
Bihan, Dominique +7 more
core +3 more sources
Study on the Ristocetin-precipitated fibrinogen and Ristocetin induced platelet aggregation
Blood & Vessel, 1977 Howard arid Firkin have described that the ristocetin induced platelet aggregation (RIPA) is defective in von Willebrand's disease (vWd), but is normal in afibrinogenemia. They also noted that ristocetin causes precipitation of fibrinogen. A key factor of RIPA seems to be the factor lacking in vWd, not fibrinogen, since a plasma level of fibrinogen is ...
Sotoharu Yamada +9 more
openaire +3 more sources