Results 171 to 180 of about 3,611 (194)

RKIP: A Governor of Intracellular Signaling

Critical Reviews in Oncogenesis, 2014
The Raf kinase inhibitor protein (RKIP) increasingly evolves as an important regulator of intracellular signaling networks and thus participates in diverse physiological functions ranging from growth and differentiation processes to muscle contraction.
Kristina, Lorenz, Evelyn, Schmid, Katharina, Deiss   +2 more
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Genetic and Epigenetic Control of RKIP Transcription

Critical Reviews in Oncogenesis, 2014
Raf kinase inhibitory protein (RKIP) is known to modulate key signaling cascades and regulate normal physiological processes such as cellular proliferation, differentiation, and apoptosis. The expression of RKIP is found to be downregulated in several cancer metastases and the repressed RKIP expression can be reactivated on treatment with ...
Ila, Datar, Hanna, Tegegne, Kevin, Qin, Fahd, Al-Mulla, Milad S, Bitar, Robert J, Trumbly, Kam C, Yeung   +6 more
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Raf kinase inhibitor protein (RKIP) in cancer

Cancer and Metastasis Reviews, 2012
Raf kinase inhibitory protein (RKIP) was initially identified as phosphatidylethanolamine binding protein in bovine brain. It was later identified as a protein that inhibits Raf kinase activation of MEK. Further exploration has revealed that RKIP modulates several other signaling pathways including NF-κB and G-protein signaling.
June, Escara-Wilke, Kam, Yeung, Evan T, Keller   +2 more
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Resveratrol binds and activates RKIP protein in colorectal cancer

Amino Acids, 2020
Raf-1 kinase inhibitory protein (RKIP) acts as a tumor cell metastasis suppressor and prognostic indicator for survival in various cancers. Its use is predicted to improve therapy for various malignancies, including colorectal cancer (CRC). RKIP, frequently denoted as phosphatidylethanolamine-binding protein 1, is expressed in all normal mammalian ...
Begum Dariya, Santosh Kumar Behera, Gowru Srivani, Sheik Aliya, Afroz Alam, Ganji Purnachandra Nagaraju   +5 more
openaire   +2 more sources

Unique Pattern of Raf-1 Kinase Inhibitory Protein (RKIP) Expression in Multiple Myeloma (MM): RKIP Overexpression and RKIP Phosphorylation Is Common in MM Tumor Cells

Blood, 2008
Abstract Objective and Rationale Raf-1 kinase inhibitor protein (RKIP) is a modulator of cell signaling and survival that functions as an endogenous inhibitor of multiple kinases, including kinases involved in the Raf-1/MEK/ERK and NF-kB pathways.
Benjamin Bonavida, James R. Berenson, Haiming Chen, Manuel L Penichet, Kam Yeung, Clara Rivera-Pazos, Ma de Lourdes Cabera-Muñoz, Sara Huerta-Yepez, Stavroula Baritaki   +8 more
openaire   +1 more source

RKIP: Much more than Raf Kinase inhibitory protein

Journal of Cellular Physiology, 2013
AbstractFrom its discovery as a phosphatidylethanolamine‐binding protein in bovine brain to its designation as a physiological inhibitor of Raf kinase protein, RKIP has emerged as a critical molecule for maintaining subdued, well‐orchestrated cellular responses to stimuli.
Fahd, Al-Mulla, Milad S, Bitar, Zainab, Taqi, Kam C, Yeung   +3 more
openaire   +2 more sources

Structural basis for RKIP binding with its substrate Raf1 kinase

Biotechnology Letters, 2014
Raf1 kinase inhibitor protein (RKIP) negatively regulates the Raf1/MEK/ERK pathway which is vital for cell growth and differentiation. It is also a biomarker in clinical cancer diagnosis. RKIP binds to the N-terminus of Raf1 kinase but little is known about the structural basis of RKIP binding with Raf1.
Wu, Zhihua, Fu, Cuiping, Shi, Lina, Ruan, Lu, Lin, Donghai, Guo, Chenyun   +5 more
openaire   +3 more sources

Unique Pattern of Raf-1 Kinase Inhibitory Protein (RKIP) Expression in Multiple Myeloma (MM) Compared to Other Tumor Types: Overexpression of RKIP and a Phosphorylated RKIP Is Common in MM Tumor Cells.

Blood, 2007
Abstract Objective and Rationale Raf-1 kinase inhibitory protein (RKIP) is a modulator of cell signaling and survival that functions as an endogenous inhibitor of multiple kinases, including kinases involved in the Raf/MEK/ERK and NF-κB pathways.
Stavroula Baritaki, Sara Huerta-Yepez, Kam Yeung, Manuel Penichet, Haiming Chen, Dror Shalitin, James Berenson, Benjamin Bonavida   +7 more
openaire   +1 more source

Cardiac RKIP induces a beneficial β-adrenoceptor–dependent positive inotropy

Nature Medicine, 2015
In heart failure therapy, it is generally assumed that attempts to produce a long-term increase in cardiac contractile force are almost always accompanied by structural and functional damage. Here we show that modest overexpression of the Raf kinase inhibitor protein (RKIP), encoded by Pebp1 in mice, produces a well-tolerated, persistent increase in ...
Evelyn Schmid, Stefan Neef, Christopher Berlin, Angela Tomasovic, Katrin Kahlert, Peter Nordbeck, Katharina Deiss, Sabrina Denzinger, Sebastian Herrmann, Erich Wettwer, Markus Weidendorfer, Daniel Becker, Florian Schäfer, Nicole Wagner, Süleyman Ergün, Joachim P Schmitt, Hugo A Katus, Frank Weidemann, Ursula Ravens, Christoph Maack, Lutz Hein, Georg Ertl, Oliver J Müller, Lars S Maier, Martin J Lohse, Kristina Lorenz   +25 more
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Clinical Significance of RKIP and Phosphorylated RKIP Expression in Human Cancers

Forum on Immunopathological Diseases and Therapeutics, 2011
Lee Goodglick, Benjamin Bonavida
openaire   +1 more source