Results 61 to 70 of about 150,391 (120)

Electroacupuncture at HT5 + GB20 promotes brain remodeling and significantly improves swallowing function in patients with stroke. [PDF]

Front Neurosci, 2023
Fu X, Li H, Yang W, Li X, Lu L, Guo H, Guo K, Huang Z.   +7 more
europepmc   +1 more source

Deconvolution of cargo delivery and immunogenicity following intranasal delivery of mRNA lipid nanoparticle vaccines

Molecular Therapy: Nucleic Acids
Intranasal vaccination aims to elicit mucosal immunity in the respiratory tract to better protect against respiratory infections (e.g., SARS-CoV-2 and influenza). Most vaccines, including recent COVID-19 mRNA lipid nanoparticles (LNPs), are optimized for
Mai N. Vu, Devaki Pilapitiya, Andrew Kelly, Marios Koutsakos, Stephen J. Kent, Jennifer A. Juno, Hyon-Xhi Tan, Adam K. Wheatley   +7 more
doaj   +1 more source

Vancomycin dosing in neonates: enhancing outcomes using population pharmacokinetics and simulation

Frontiers in Antibiotics
IntroductionOptimizing vancomycin dosing in neonates is a critical yet complex goal. Traditional trough concentration-based dosing strategies correlate poorly with therapeutic efficacy and often fail to account for the significant renal function ...
Sílvia M. Illamola, Jiraganya (JJ) Bhongsatiern, Jiraganya (JJ) Bhongsatiern, Angela K. Birnbaum, Angela K. Birnbaum, Shaun S. Kumar, Joshua D. Courter, David B. Haslam, Karel Allegaert, Karel Allegaert, Karel Allegaert, David M. Reith, Pankaj B. Desai, Catherine M. Sherwin, Catherine M. Sherwin, Catherine M. Sherwin, Catherine M. Sherwin, Catherine M. Sherwin   +17 more
doaj   +1 more source

Patterns of treatment and outcomes of patients with metastatic HER2-low breast cancer treated with CDK4/6 inhibitors and hormone therapy

Drugs in Context
Background: The 2018 American Society of Clinical Oncology/College of American Pathologists guidelines classified immunohistochemistry (IHC) 1+ or 2+, FISH-negative breast cancer as HER2-low. To date, only a few studies have investigated the role of HER2-
Federico Sottotetti, Barbara Tagliaferri, Gianpiero Rizzo, Raffaella Palumbo, Giulia Chessa, Chiara Raso, Lorenzo Perrone, Alberto Malovini, Valentina Tibollo, Laura Deborah Locati, Paolo Pedrazzoli, Angioletta Lasagna   +11 more
doaj   +1 more source

20(S)-protopanaxadiol inhibits proliferation and induces apoptosis of acute myeloid leukemia cells via targeting Bcl-XL and MCL-1

Frontiers in Pharmacology
Currently, intensive chemotherapy with cytarabine and anthracycline (the “7 + 3” regimen) and hypomethylating agents remains the standard treatment for patients with acute myeloid leukemia (AML).
Meng Xu, Meng Xu, Meng Xu, Feng Hao, Shuangshuang Wu, Zhanning Qu, Zhanning Qu, Junying Li, Shuang Chen, Fang Fang, Yundong Zhao, Cheng Hu   +11 more
doaj   +1 more source

Curcumin: a potential anti-photoaging agent

Frontiers in Pharmacology
Turmeric, also referred to as Curcuma longa, is a commonly used spice, recognized for its demonstrated effects in reducing inflammation, combating microbes, providing antioxidant benefits, slowing the aging process, and exhibiting anticancer potential ...
Yuhong Nie, Yiming Li
doaj   +1 more source

Synergistic interaction network between the snR30 RNP, Utp23, and ribosomal RNA during ribosome synthesis. [PDF]

RNA Biol, 2022
Vos TJ, Kothe U.
europepmc   +1 more source

Case Report: Linezolid-associated toxic optic neuropathy in patients with pulmonary tuberculosis: case series and mini review

Frontiers in Pharmacology
Linezolid is a useful second-line medication for the treatment of tuberculosis that is resistant to multiple drugs. However, long-term therapy can cause side effects, such as optic neuropathy.
Hee Jin Yun, Hee Jin Yun, Su-Jin Kim, Su-Jin Kim, Kwang Eon Han, Kwang Eon Han, Eun Jung Choi, Ji-Eun Lee, Ji-Eun Lee   +8 more
doaj   +1 more source

An ion mobility-mass spectrometry study of copper-metallothionein-2A: binding sites and stabilities of Cu-MT and mixed metal Cu-Ag and Cu-Cd complexes. [PDF]

Analyst, 2023
Fan L, Russell DH.
europepmc   +1 more source

Efficacy and safety of baihe gujin decoction as an adjunct to chemotherapy in pulmonary tuberculosis: A systematic review and meta-analysis

Frontiers in Pharmacology
BackgroundPulmonary tuberculosis (PTB), an ancient affliction, continues to present significant challenges in modern medicine. Baihe Gujin Decoction, a traditional Chinese botanical drug remedy, has been widely utilized in clinical practice for ...
Yilu Zhao, Yilu Zhao, Yiran Han, Jia Liu, Honghong Niu, Peilong Wang, Yuxi Li, Jianqin Liang, Jianqin Liang, Wenping Gong   +9 more
doaj   +1 more source