Results 61 to 70 of about 201,194 (169)

Roselle (Hibiscus sabdariffa L.) extract as an adjunct to valsartan in patients with mild chronic kidney disease: A double-blind randomized controlled clinical trial [PDF]

Avicenna Journal of Phytomedicine
Objective: The objective of this study was to evaluate theeffectiveness of Hibiscus sabdariffa L. extract (HS) as an adjunctto valsartan in the treatment of high blood pressure in patients withmild chronic kidney disease (CKD).Materials and Methods: This
Behdad Dehkhoda, Ayesheh Enayati, Hassan Mirzaei, Somayeh Ghorbani, Mohammad Hadi Soleimani, Saeid Amirkhanlou, Amirhossein Sahebkar   +6 more
doaj   +1 more source

USP7 promotes cardiometabolic disorders and mitochondrial homeostasis dysfunction in diabetic mice via stabilizing PGC1β

Pharmacological Research
Diabetic cardiomyopathy (DCM) is a major complication of diabetes and is characterized by left ventricular dysfunction. Currently, there is a lack of effective treatments for DCM. Ubiquitin-specific protease 7 (USP7) plays a key role in various diseases.
Meiling Yan, Liyan Su, Kaile Wu, Yu Mei, Zhou Liu, Yifan Chen, Wenru Zeng, Yang Xiao, Jingfei Zhang, Guida Cai, Yunlong Bai   +10 more
doaj   +1 more source

Discovery of a CCR2-targeting pepducin therapy for chronic pain

Pharmacological Research
Targeting the CCL2/CCR2 chemokine axis has been shown to be effective at relieving pain in rodent models of inflammatory and neuropathic pain, therefore representing a promising avenue for the development of non-opioid analgesics.
Élora Midavaine, Rebecca L. Brouillette, Elizabeth Théberge, Christine E. Mona, Sakeen W. Kashem, Jérôme Côté, Vera Zeugin, Élie Besserer-Offroy, Jean-Michel Longpré, Éric Marsault, Philippe Sarret   +10 more
doaj   +1 more source

Effects of microwaves (950 MHZ mobile phone) on morphometric and apoptotic changes of rabbit epididymis

Andrologia, 2015
The effect of mobile phone radiation on human reproduction system is still a matter of debate. In this study, 18 male rabbits were randomly divided into two experimental groups and one control group. Experimental groups received simulated microwaves with
E. A. Oskouyi, F. Rajaei, A. S. Variani, M. Sarokhani, A. Javadi   +4 more
semanticscholar   +1 more source

Conformational Analysis of Toxogonine, TMB-4 and HI-6 using PM6 and RM1 methods

, 2010
In this work, after validation by comparison with results obtained by DFT, the semi-empirical methods RM1 and PM6 were employed to perform conformational analysis of three oximes employed in chemical defense.
A. S. Gonçalves, T. C. França, J. Figueroa-Villar, P. Pascutti   +3 more
semanticscholar   +1 more source

Investigation of the mechanism underlying the Vasoprotective effects of red yeast rice extract in spontaneously hypertensive rats [PDF]

Hypertension is linked to endothelial dysfunction, characterized by an imbalance between relaxing and constricting factors in the vasculature. Increased activity in the renin-angiotensin-aldosterone system (RAAS) is implicated in hypertension as it ...
Tan, Jiunn Jye
core  

Adhesion between EVs and tumor cells facilitated EV-encapsulated doxorubicin delivery via ICAM1

Pharmacological Research
Doxorubicin (Dox) is an anti-tumor drug with a broad spectrum, whereas the cardiotoxicity limits its further application. In clinical settings, liposome delivery vehicles are used to reduce Dox cardiotoxicity.
Shibo Wang, Chenxiao Qiao, Xianghui Kong, Jie Yang, Fei Guo, Jiming Chen, Wenhui Wang, Bei Zhang, Huiqing Xiu, Yuzhou He, Jianli Wang, Huajun Feng, Zhijian Cai   +12 more
doaj   +1 more source

Electroacupuncture at HT5 + GB20 produces stronger activation effect on swallowing cortex and muscle than single points. [PDF]

Heliyon, 2023
Fu X, Li H, Yang W, Li X, Lu L, Guo H, Wu Z, Guo K, Xu H, Huang Z.   +9 more
europepmc   +1 more source

Identification of an osteopontin-derived peptide that binds neuropilin-1 and activates vascular repair responses and angiogenesis

Pharmacological Research
The osteopontin-derived peptide FOL-005 stimulates hair growth. Using ligand-receptor glyco-capture technology we identified neuropilin-1 (NRP-1), a known co-receptor for vascular endothelial growth factor (VEGF) receptors, as the most probable receptor ...
Yihong Chen, Chrysostomi Gialeli, Junyan Shen, Pontus Dunér, Björn Walse, Annette Duelli, Rhawnie Caing-Carlsson, Anna M. Blom, John R. Zibert, Anna Hultgårdh Nilsson, Jan Alenfall, Chun Liang, Jan Nilsson   +12 more
doaj   +1 more source

Advancing personalized medicine in neurodegenerative diseases: The role of epigenetics and pharmacoepigenomics in pharmacotherapy

Pharmacological Research
About 80 % of brain disorders have a genetic basis. The pathogenesis of most neurodegenerative diseases is associated with a myriad of genetic defects, epigenetic alterations (DNA methylation, histone/chromatin remodeling, miRNA dysregulation), and ...
Christian Griñán-Ferré, Aina Bellver-Sanchis, Ana Guerrero, Mercè Pallàs   +3 more
doaj   +1 more source