Results 51 to 60 of about 58,524 (271)

A Radioresistant‐Tumor‐Targeted Nanoparticle for X‐Ray‐Controlled Nitric Oxide Release to Potentiate Radiotherapy

Advanced Science, EarlyView.
The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang, Xiaoyan Yin, Ting Wang, Hongfu Zhao, Zhipeng Zhao, Jinbao Wang, Cheng Tao, Xuanchu Ge, Yanze Li, Linlin Liu, Fuxin Xue   +10 more
wiley   +1 more source

Thin-layer agar for detection of resistance to rifampicin, ofloxacin and kanamycin in Mycobacterium tuberculosis isolates [PDF]

, 2009
BACKGROUND: In low-income countries there is a great need for economical methods for testing the susceptibility of Mycobacterium tuberculosis to antibiotics. OBJECTIVE: To evaluate the thin-layer agar (TLA) for rapid detection of resistance to rifampicin
Almeida, P, Fissette, K, Martin, A, Paasch, F, Palomino, J-C, Portaels, F, Varaine, F, Von Groll, A   +7 more
core   +1 more source

A note on "A LP-based heuristic for a time-constrained routing problem" [PDF]

, 2012
In their paper, Avella et al. (2006) investigate a time-constrained routing problem. The core of the proposed solution approach is a large-scale linear program that grows both row- and column-wise when new variables are introduced. Thus, a column-and-row
Birbil, S. Ilker, Birbil, Ş. İlker, Bulbul, Kerem, Bülbül, Kerem, Muter, İbrahim, Muter, Ibrahim, Sahin, Guvenc, Şahin, Güvenç   +7 more
core   +1 more source

Sustainable Synaptic Device with Two‐Dimensional Ferroelectric Materials for Neuromorphic Computing

Advanced Science, EarlyView.
α‐In2Se3 based FeSFETs can be utilized as sustainable devices through polarization switching governed by both out‐of‐plane and in‐plane polarizations. Upon reaching a fatigued state, current annealing enabled by conductance modulation can significantly enhance the endurance of FeSFETs.
Jaewook Yoo, Seokjin Oh, Minah Park, Jong Min Song, Hongseung Lee, Seohyeon Park, Sojin Jung, Seongbin Lim, Soohyun Lim, Dongsun Shin, Ji Won Heo, TaeWan Kim, Hagyoul Bae   +12 more
wiley   +1 more source

Co‐Occurring Non‐Cardiac Congenital Anomalies Among Cases With Congenital Heart Defects

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Cases with congenital heart defects (CHD) often have other associated anomalies. The aim of this investigation was to assess the prevalence and the types of co‐occurring anomalies in CHD in a well‐defined population. The anomalies co‐occurring with CHD were ascertained in all live births, stillbirths and terminations of pregnancy for fetal ...
Claude Stoll, Yves Alembik, Marie‐Paule Roth   +2 more
wiley   +1 more source

Current situation and issues regarding termination of risk management plans in Japan

Frontiers in Medicine
IntroductionIn Japan, drugs approved after the 2013 implementation of the risk management plan (RMP) have the opportunity to be evaluated for RMP termination. However, the guidelines for risk management following the termination of an RMP remain unclear.
Natsuko Kameyama, Aoi Hosaka, Hideki Maeda, Hideki Maeda   +3 more
doaj   +1 more source

Low awareness of risk mitigation prescribing in response to dual crises of COVID-19 and overdose deaths among people who use unregulated drugs in Vancouver, Canada

Harm Reduction Journal, 2022
Background When the novel coronavirus pandemic emerged in March 2020, many settings across Canada and the USA were already contending with an existing crisis of drug overdoses due to the toxic unregulated drug supply.
Mana Moshkforoush, Kora DeBeck, Rupinder Brar, Nadia Fairbairn, Zishan Cui, M.-J. Milloy, Jane Buxton, Tanis Oldenburger, Will McLellan, Perry Kendall, Kali Sedgemore, Dean Wilson, Thomas Kerr, Kanna Hayashi   +13 more
doaj   +1 more source

Neighbors, Drought, and Nitrogen Application Affect the Root Morphological Plasticity of Dalbergia odorifera

Frontiers in Plant Science, 2021
In forest systems, neighbor-induced root morphological plasticity (RMP) is species specific and environment dependent. However, related studies on leguminous woody trees remain sparse.
Li-Shan Xiang, Li-Shan Xiang, Ling-Feng Miao, Ling-Feng Miao, Fan Yang, Fan Yang, Fan Yang   +6 more
doaj   +1 more source

Mitigating unfavourable treatment outcomes and acquired rifampicin resistance in isoniazid-resistant tuberculosis: the role of fluoroquinolone

Journal of Microbiology, Immunology and Infection
Background: Rifampicin (RMP), ethambutol, and pyrazinamide (PZA) for 6–9 months were recommended for the management of isoniazid-resistant, rifampicin-susceptible tuberculosis (Hr-TB), but recommendations on fluoroquinolones (FQs) were inconsistent.
Pin-Hui Lee, Ching-Han Liu, Pei-Chun Chan, Ya-Chun Yang, Po-Wei Chu, Chi-Fang Feng, Hsiu-Yun Lo, Chia-Chi Lee, Chen-Yuan Chiang   +8 more
doaj   +1 more source

Mechanisms of Protective Effect of Ramulus Mori Polysaccharides on Renal Injury in High-Fat Diet/Streptozotocin-Induced Diabetic Rats

Cellular Physiology and Biochemistry, 2015
Background: Diabetic nephropathy (DN) is the most important complication of diabetes and the most common cause of end-stage renal disease (ESRD). Aims: A recent study established that the Ramulus mori polysaccharides (RMP) exert antioxidant effects on DN
Xi Li, Ling Wang, Xingxin Gao, Guoping Li, Honghua Cao, Dezhi Song, Shuangqi Cai, Tao Liang, Bo Zhang, Gang Du   +9 more
doaj   +1 more source