Results 51 to 60 of about 20,565 (264)

GBL altered RMP of differentiated LNCaP.

, 2016
A. Stimulation of differentiated LNCaP cells with 40 mM GBL caused a significant depolarization of the RMP. B. Treatment with 40 mM GBL for 2–3 min resulted in a significant depolarization of the RMP (p≤0.05 using single tail, unequal variance, unpaired ...
Madan K. Kharel (534542), Qiaojuan Zhang (3044781), Feng Chen (25347), Miguel Martin-Caraballo (296198), Kevin Rochford (3044775), S. Victor Hsia (3044787), Robert W. Figliozzi (3044778), Yan Waguespack (3044784)   +7 more
core   +1 more source

Augmentation of Rotator Cuff Repair With a Bioinductive Collagen Scaffold: The Arthroscopic Slide Technique

Arthroscopy Techniques, EarlyView.
Abstract Rotator cuff repair continues to be one of the most common orthopaedic surgeries performed. However, depending on patient risk factors, retear rates remain high. We describe a technique for tensioning a collagen scaffold to supplement rotator cuff repair using laterally based pulley sutures.
Peter A. Bueide, Jordan D. Shearer, Ryan M. Peldo, Nathan W. Skelley   +3 more
wiley   +1 more source

Decoding RNA regulation: Challenges and opportunities for RNA‐based therapies in Europe

British Journal of Clinical Pharmacology, EarlyView.
Abstract RNA‐based medicinal products represent a promising frontier in personalised medicine, offering sequence‐specific disease targeting at various molecular levels, yet their clinical translation in the European Union (EU) may be hindered by regulatory uncertainty around definitions and evidence requirements; this study therefore aims to identify ...
Olivia C. Lewis, Christine Leopold, Joyce M. Hoek, Raymond M. Schiffelers, Marie L. De Bruin   +4 more
wiley   +1 more source

Mutations in the rpoB gene of rifampicin-resistant Mycobacterium tuberculosis strains isolated in Brazil and France

Memorias do Instituto Oswaldo Cruz, 2001
We evaluated the mutations in a 193bp of the rpoB gene by automated sequencing of rifampicin (RMP)-resistant and susceptible Mycobacterium tuberculosis strains isolated from Brazil (25 strains) and France (37 strains). In RMP-resistant strains, mutations
S Spindola de Miranda, AL Kritski, I Filliol, C Mabilat, G Panteix, E Drouet   +5 more
doaj   +1 more source

Cell and Gene Therapies Manufacturing Challenges and Integrated Good Manufacturing Practices Solutions: A Lifecycle Perspective

Biotechnology and Bioengineering, EarlyView.
Lifecycle perspective on cell and gene therapy manufacturing challenges and enabling GMP solutions. ABSTRACT Cell and gene therapies (CGTs) are revolutionizing modern medicine; however, making these advanced medicines scalable and readily available to commercial manufacturers worldwide is a major challenge. The number of approved CGT products continues
Rajath Samaga, Udisha Singh, Sachin Dattram Pawar   +2 more
wiley   +1 more source

rMP-12 NSs-3XFlag F261S has reduced replication capability in HSAECs, but not Vero cells.

HSAECs (panel A) or Vero cells (panel B) were infected with rMP-12 NSs-3XFlag or rMP-12 NSs-3XFlag F261S at an MOI of 3. Supernatants were collected at 4, 8, 16, 24, 48, and 72 h post infection and viral titers determined by plaque assay.
Paul O’Maille (18196747), Raphaël Cafaro (18196741), Normand Cyr (8897279), Kaylee Petraccione (18196726), Nicole Bracci (8259813), James Omichinski (6059414), Kylene Kehn-Hall (45085), Danuta Sastre (5074088), Ivan Akhrymuk (2934816), Lauren Panny (10481461), Andrew Silberfarb (18196744), Mohamed G. H. Ali (18196729), Haytham M. Wahba (18196732), Timothy Stocker (18196735), Maryna Akhrymuk (18196738)   +14 more
core   +1 more source

Multimodal Fluorescent MOF@BODIPY Platform: Bridging Sensing and Mechanistic Insight

Chemistry – A European Journal, EarlyView.
ABSTRACT Hybrid metal–organic frameworks (MOFs) that integrate organic chromophores constitute powerful platforms for optical sensing by combining structural order with tunable photophysics. Incorporating photoresponsive chromophores into MOFs enables sensitive probing of guest–framework interactions through well‐defined luminescent signatures. Herein,
Alejandro Cortés‐Villena, Paula Rodrigo‐Martínez, José A. Sáez, Pablo Gaviña, Emilio Pardo, Raquel E. Galian, Sergio Armenta, Héctor Martínez‐Pérez‐Cejuela, José Manuel Herrero‐Martínez   +8 more
wiley   +1 more source

Effect of Magnetic Islands on Neoclassical Heat Diffusivity in a Global Tokamak Simulation

Contributions to Plasma Physics, EarlyView.
ABSTRACT Resonant magnetic perturbations (RMPs) alter magnetic field topology via island formation and can modify core transport in toroidal fusion devices. Using the global gyrokinetic particle‐in‐cell code XGC‐S, originally developed for stellarator geometries, we quantify how island topology affects neoclassical heat transport in a circular tokamak ...
Joseph X. Li, Toseo Moritaka, Ryutaro Kanno, Gakushi Kawamura, Robert Hager, C.‐S. Chang   +5 more
wiley   +1 more source

Elevated Red Cell Microparticles (RMP) in Hematologic and Thrombotic Disorders

, 2015
Introduction. Circulating cell-derived microparticlesa (MP) from platelets (PMP), leukocytes (LMP), and endothelia (EMP) have been well-documented for their roles in hemostasis, thrombosis and inflammation but the clinical significance of RMP is less ...
Jy, Wenche, Horstman, Lawrence L, Dudkiewicz, Pamela, Ahn, Yeon-Soong, Bidot, Carlos, Tinoco, Gabriel, EL Dinali, Mohamed   +6 more
core   +1 more source

Challenges in Implementing European Regulation on Water Reuse for Sustainable Agriculture

Environmental Policy and Governance, EarlyView.
ABSTRACT The Regulation (EU) 2020/741 on minimum requirements for water reuse is a key policy for sustainable water management under growing water scarcity in Europe. This paper examines expert perspectives on the challenges involved in implementing EU regulation for water reuse in agriculture, aiming to broaden existing research, which is largely ...
Patricia Allgaier, Roberta Maffettone, Kevin Grecksch   +2 more
wiley   +1 more source