Results 231 to 240 of about 298,098 (305)

Transposable element-gene chimera cartography, origination and role in enhancing transcriptome plasticity. [PDF]

Nat Struct Mol Biol
Cheon Y, Alvstad EG, Torre D, Quach DT, Nguyen J, Hyun K, Zhou M, Yu T, Liu L, Yoon Y, Reese F, Faraone L, Li Y, Arnold FJ, Fstkchyan YS, Basu U, Kvon E, Valente EM, Ho JSY, Byun M, Guccione E, Shi Y, Weng Z, Seldin M, Marazzi I.   +24 more
europepmc   +1 more source

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

The FEBS Journal, EarlyView.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy, Zsolt Fazekas, Nóra Wágner, Anna J. Kiss‐Szemán, Veronika Harmat, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel   +7 more
wiley   +1 more source

Metabolic Dysfunction-Associated Steatotic Liver Disease and Emerging Oligonucleotide Therapies. [PDF]

Int J Biol Sci
Chen Q, Jiang J, Chiang Z, Li X, Zhang L, Wang L, Tse HF, Wang S, Lian Q.   +8 more
europepmc   +1 more source

Post‐transcriptional regulatory networks: The dynamic interplay of RNA‐binding proteins

The FEBS Journal, EarlyView.
Post‐transcriptional gene expression regulation is controlled by RNA‐binding proteins (RBPs), which influence many processes including splicing, localization, translation, and decay. Rather than acting alone, RBPs bind RNAs combinatorially, forming complex, context‐dependent regulatory networks.
Lena A. Street, Marko Jovanovic, Eugenio F. Fornasiero   +2 more
wiley   +1 more source

Long non-coding RNA KCNQ1OT1 promotes ovarian cancer cell malignant characteristics by targeting the miR-140-5p/KLK10 axis. [PDF]

Exp Ther Med
Duan R, Tao Z, Tao S, Yang A, Yang X, Li C, Zhu X, Zhang K, Li Z, Tao S.   +9 more
europepmc   +1 more source

Toward a Functional Cure for Chronic Hepatitis B: Current Landscape and Future Directions in Japan

Hepatology Research, EarlyView.
Hepatitis B is a viral liver infection that can become chronic, increasing the risk of developing liver cancer and liver failure. Because current treatments rarely cure these problems, researchers are now focusing on a functional cure in which the virus becomes undetectable in blood and stays that way, even after the treatment ends.
Yutaka Handa, Ethan Yichen Lee, Yasuhito Tanaka   +2 more
wiley   +1 more source

Harnessing exosomal long non-coding RNAs as a new frontier for molecular diagnostics and therapeutics in diabetes mellitus. [PDF]

Cell Commun Signal
Midan HM, Wasfey EF, Doghish AS, Kamal MM, Kassem DH.   +4 more
europepmc   +1 more source

Emerging experimental and bioinformatic approaches in RNA interference‐based pest control research

Insect Molecular Biology, EarlyView.
Double‐stranded RNA (dsRNA) visualization, RNA‐induced silencing complex (RISC)‐bound sRNA‐seq and RNA degradomics allow investigating dsRNA uptake and processing, guide small interfering RNA selection and RISC‐mediated target mRNA cleavages. Transcriptomic and proteomic profiles of genome‐wide responses to dsRNA, including off‐target and compensatory ...
Doga Cedden
wiley   +1 more source

Comparative genomics identifies small interfering RNA with activity against all five human betacoronaviruses. [PDF]

Genome Med
Vogler J, Ambike S, Velkov S, Cheng CC, Neubecker P, Fischhaber N, Mallick P, Martan I, Sauerhering L, von Brunn A, Protzer U, Michler T.   +11 more
europepmc   +1 more source

Cytosolic delivery of bacterial metabolites by riboflavin transporters promotes MR1 antigen presentation and MAIT cell recognition

Immunology &Cell Biology, EarlyView.
VitBAg antigen presentation is promoted through a cytosolic pathway that reaches ligand‐receptive MR1 to present to MAIT cells, like the riboflavin transport pathway. Riboflavin solute carrier transporters can promote this MR1 presentation, but they are not essential for this role, suggesting redundant pathways to uptake VitBAg.
Sebastian Cruz‐Gomez, Hui Jing Lim, Brunda Nijagal, Yuting Yang, Nicole Lau, Jeffrey YW Mak, David P Fairlie, Hayley Newton, Mariolina Salio, Jose A Villadangos, Hamish EG McWilliam   +10 more
wiley   +1 more source