Results 251 to 260 of about 959,158 (292)
Some of the next articles are maybe not open access.
Nature Chemical Biology, 2007
RNA interference provides powerful tools for controlling gene expression in cultured cells. Whether RNAi will provide similarly powerful drugs is unknown. Lessons from development of antisense oligonucleotide drugs may provide some clues.
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RNA interference provides powerful tools for controlling gene expression in cultured cells. Whether RNAi will provide similarly powerful drugs is unknown. Lessons from development of antisense oligonucleotide drugs may provide some clues.
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Antisense RNA therapy for CML — An hypothesis
Medical Hypotheses, 1991CML, a myeloproliferative clonal disorder of myeloid stem cells, is characterized by the consistent presence of a bcr-c-abl fusion gene which is formed as a result of a translocation of the c-abl gene from chromosome 9 to downstream of the bcr gene on chromosome 22 (ph').
K S, Nadkarni, R H, Datar, S G, Rao
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1996
Antisense RNAs are small, diffusible, untranslated RNAs that pair to complementary regions on specific target RNAs, altering the expression or function of those RNAs post-transcriptionally. Antisense RNA control is well documented in bacteria, especially in their accessory elements—plasmids, bacteriophages and transposable elements (see Table 5.1).
Brian N. Zeiler, Robert W. Simons
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Antisense RNAs are small, diffusible, untranslated RNAs that pair to complementary regions on specific target RNAs, altering the expression or function of those RNAs post-transcriptionally. Antisense RNA control is well documented in bacteria, especially in their accessory elements—plasmids, bacteriophages and transposable elements (see Table 5.1).
Brian N. Zeiler, Robert W. Simons
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In vitro and in vivo action of antisense RNA
Molecular Biotechnology, 1996The transient or permanent expression of antisense RNA represents one option to apply antisense techniques in biotechnology and medical research. Despite the increasing importance and use of antisense nucleic acids as well as their significant antisense-specific phenotypic effects in vivo, there is an obvious lack of explanation for the mechanism of ...
W, Nellen, G, Sczakiel
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Antisense RNA Elements for Downregulating Expression
2019Antisense RNA (asRNA) technology is an important tool for downregulating gene expression. When applying this strategy, the asRNA interference efficiency is determined by several elements including scaffold design, loop size, and relative abundance. Here, we take the Escherichia coli gene fabD encoding malonyl-CoA-[acyl-carrier-protein] transacylase as ...
Yaping, Yang +3 more
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Critical Reviews in Biochemistry and Molecular Biology, 1990
K M, Takayama, M, Inouye
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K M, Takayama, M, Inouye
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Antisense technology: an overview and prospectus
Nature Reviews Drug Discovery, 2021Xue-Hai Liang +2 more
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