Results 261 to 270 of about 298,098 (305)

BIOLOGICAL REGULATION BY ANTISENSE RNA IN PROKARYOTES

Annual Review of Genetics, 1988
Article de synthese sur le controle de l'expression des genes par les ARN antisens chez les procaryotes, structure secondaire et relations structure ...
R W, Simons, N, Kleckner
openaire   +2 more sources

Antisense probing of dynamic RNA structures

Methods, 2020
RNA regulation is influenced by the dynamic changes in conformational accessibility on the transcript. Here we discuss the initial validation of a cell-free antisense probing method for structured RNAs, using the Tetrahymena group I intron as a control target.
Alexandra J, Lukasiewicz, Lydia M, Contreras   +1 more
openaire   +2 more sources

Naturally occurring antisense RNA

Pharmacology & Therapeutics, 1997
Within the last few years a number of mammalian genes have been found for which there exist naturally occurring "antisense" RNA species with complementarity to mRNAs. Effects of antisense RNA on "sense" RNA have yet to be established. Nevertheless, it is apparent that mammalian cells have devoted genetic information and machinery to processing RNA:RNA ...
openaire   +2 more sources

Targeting RNA structures by antisense oligonucleotides

Biochimie, 1996
The presence of folded regions in RNA competes with the binding of a complementary oligonucleotide, resulting in a weak antisense effect. Due to the key role played by a number of RNA structures in the natural regulation of gene expression it might be of interest to design antisense sequences able to selectively interact with such motifs in order to ...
J J, Toulmé, R L, Tinévez, E, Brossalina   +2 more
openaire   +2 more sources

RNA learns from antisense

Nature Chemical Biology, 2007
RNA interference provides powerful tools for controlling gene expression in cultured cells. Whether RNAi will provide similarly powerful drugs is unknown. Lessons from development of antisense oligonucleotide drugs may provide some clues.
openaire   +2 more sources

THE ROLE OF ANTISENSE RNA IN GENE REGULATION

Annual Review of Biochemistry, 1986
PERSPECTIVES AND SUMMARY ... ... 569 PROKARYOTIC ANTISENSE REGULATORY SYSTEMS 570 Plasmid Replication 570 TnlO Transposition ... ... ... ... 574 Bacterial and Phage Gene Expression 576 Artificial Antisense RNA (micRNA) 579 mic Immune System 582 ANTISENSE RNA IN EUKARYOTIC SySTEMS 584 Antisense Genes 584 Microinjection of Antisense ...
P J, Green, O, Pines, M, Inouye
openaire   +2 more sources

Antisense RNA therapy for CML — An hypothesis

Medical Hypotheses, 1991
CML, a myeloproliferative clonal disorder of myeloid stem cells, is characterized by the consistent presence of a bcr-c-abl fusion gene which is formed as a result of a translocation of the c-abl gene from chromosome 9 to downstream of the bcr gene on chromosome 22 (ph').
K S, Nadkarni, R H, Datar, S G, Rao
openaire   +2 more sources

ANTISENSE RNA

Annual Review of Biochemistry, 1991
Y, Eguchi, T, Itoh, J, Tomizawa
openaire   +3 more sources

In vitro and in vivo action of antisense RNA

Molecular Biotechnology, 1996
The transient or permanent expression of antisense RNA represents one option to apply antisense techniques in biotechnology and medical research. Despite the increasing importance and use of antisense nucleic acids as well as their significant antisense-specific phenotypic effects in vivo, there is an obvious lack of explanation for the mechanism of ...
W, Nellen, G, Sczakiel
openaire   +2 more sources

Control by Antisense RNA

1996
Antisense RNAs are small, diffusible, untranslated RNAs that pair to complementary regions on specific target RNAs, altering the expression or function of those RNAs post-transcriptionally. Antisense RNA control is well documented in bacteria, especially in their accessory elements—plasmids, bacteriophages and transposable elements (see Table 5.1).
Brian N. Zeiler, Robert W. Simons
openaire   +1 more source