Results 41 to 50 of about 445,040 (271)
Dynamic competition between transcription initiation and repression: Role of nonequilibrium steps in cell-to-cell heterogeneity [PDF]
Phys. Rev. E 92, 022710 (2015), 2015 Transcriptional repression may cause transcriptional noise by a competition between repressor and RNA polymerase binding. Although promoter activity is often governed by a single limiting step, we argue here that the size of the noise strongly depends on whether this step is the initial equilibrium binding or one of the subsequent unidirectional steps.
arxiv +1 more source
Steric interactions and out-of-equilibrium processes control the internal organization of bacteria [PDF]
, 2021 Despite the absence of a membrane-enclosed nucleus, the bacterial DNA is typically condensed into a compact body - the nucleoid. This compaction influences the localization and dynamics of many cellular processes including transcription, translation, and cell division.
arxiv +1 more source
Bacterial RNA Biology on a Genome Scale [PDF]
Molecular Cell, 2018 Bacteria are an exceedingly diverse group of organisms whose molecular exploration is experiencing a renaissance. While the classical view of bacterial gene expression was relatively simple, the emerging view is more complex, encompassing extensive post-transcriptional control involving riboswitches, RNA thermometers, and regulatory small RNAs (sRNAs ...
Hör, Jens +2 more
openaire +3 more sources
An RNA Surprise in Bacterial Effector Mechanisms [PDF]
Cell Host & Microbe, 2019 Bacterial pathogens secrete effector proteins to manipulate host signaling proteins and cellular structures. In this issue of Cell Host & Microbe, Pagliuso et al. (2019) propose an effector mechanism in Listeria monocytogenes whereby an RNA-binding protein associates with bacterial RNA that stimulates RIG-I (retinoic acid inducible gene I)-based innate
Gerovac, Milan, Vogel, Jörg
openaire +3 more sources
Sotrovimab retains activity against SARS-CoV-2 omicron variant BQ.1.1 in a non-human primate model
Heliyon, 2023 The SARS-CoV2 Omicron variants have acquired new Spike mutations leading to escape from the most of the currently available monoclonal antibody treatments reducing the options for patients suffering from severe Covid-19.
Cécile Hérate +13 more
doaj
Novel Peptide Conjugates of Modified Oligonucleotides for Inhibition of Bacterial RNase P
Frontiers in Pharmacology, 2019 Novel alternatives to traditional antibiotics are now of great demand for the successful treatment of microbial infections. Here, we present the engineering and properties of new oligonucleotide inhibitors of RNase P, an essential bacterial enzyme.
Darya Novopashina +17 more
doaj +1 more source
Small RNAs in Bacterial Virulence and Communication [PDF]
Microbiology Spectrum, 2016 ABSTRACT Bacterial pathogens must endure or adapt to different environments and stresses during transmission and infection. Posttranscriptional gene expression control by regulatory RNAs, such as small RNAs and riboswitches, is now considered central to adaptation in many bacteria, including pathogens.
Sarah L. Svensson, Cynthia M. Sharma
openaire +2 more sources
Whole genome mapping of 5' RNA ends in bacteria by tagged sequencing : A comprehensive view in Enterococcus faecalis [PDF]
, 2014 Enterococcus faecalis is the third cause of nosocomial infections. To obtain the first comprehensive view of transcriptional organizations in this bacterium, we used a modified RNA-seq approach enabling to discriminate primary from processed 5'RNA ends. We also validated our approach by confirming known features in Escherichia coli.
arxiv +1 more source
Transcription-translation machinery -- an autocatalytic network coupling all cellular cycles and generating a plethora of growth laws [PDF]
arXiv, 2021 Recently discovered simple quantitative relations, known as bacterial growth laws, hint on the existence of simple underlying principles at the heart of bacterial growth. In this work, we provide a unifying picture on how these known relations, as well as new relations that we derive, stems from a universal autocatalytic network common to all bacteria,
arxiv
Growth-rate dependent partitioning of RNA polymerases in bacteria [PDF]
Proc. Natl. Acad. Sci. USA 105, 20245-20250 (2008), 2008 Physiological changes which result in changes in bacterial gene expression are often accompanied by changes in the growth rate for fast adapting enteric bacteria. Since the availability of RNA polymerase (RNAP) in cells is dependent on the growth rate, transcriptional control involves not only the regulation of promoters, but also depends on the ...
arxiv +1 more source