Results 81 to 90 of about 445,040 (271)

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

FEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law, Yuan Gao, Sravya Kovvali, Pankajavalli Thirugnanasambantham, Vicki H. Wysocki, Brian M. M. Ahmer, Venkat Gopalan   +6 more
wiley   +1 more source

An improved bacterial mRNA enrichment strategy in dual RNA sequencing to unveil the dynamics of plant-bacterial interactions

Plant Methods
Background Dual RNA sequencing is a powerful tool that enables a comprehensive understanding of the molecular dynamics underlying plant-microbe interactions.
Jayabalan Shilpha, Junesung Lee, Ji-Su Kwon, Hyun-Ah Lee, Jae-Young Nam, Hakgi Jang, Won-Hee Kang   +6 more
doaj   +1 more source

Modified RNA-seq method for microbial community and diversity analysis using rRNA in different types of environmental samples. [PDF]

PLoS ONE, 2017
RNA-seq-based SSU (small subunit) rRNA (ribosomal RNA) analysis has provided a better understanding of potentially active microbial community within environments.
Yong-Wei Yan, Bin Zou, Ting Zhu, Wael N Hozzein, Zhe-Xue Quan   +4 more
doaj   +1 more source

Characterisation of the role played by ELMO1, GPR141 and the intergenic polymorphism rs918980 in Fuchs' dystrophy in the Indian population

FEBS Open Bio, EarlyView.
This study reports the upregulation of ELMO1 and GPR141 in human Fuchs' endothelial corneal dystrophy (FECD) corneal endothelium and ultraviolet A‐induced FECD mice model. A genetic association of an intergenic single nucleotide polymorphism rs918980 present between both genes is observed with FECD in the Indian population.
Susmita Sharma, Samar Kumar Basak, Sujata Das, Debasmita Pankaj Alone   +3 more
wiley   +1 more source

Agnodice: indexing experimentally supported bacterial sRNA-RNA interactions

mBio
In the last decade, the immense growth in the field of bacterial small RNAs (sRNAs), along with the biotechnological breakthroughs in Deep Sequencing permitted the deeper understanding of sRNA-RNA interactions.
Vasiliki Kotsira, Giorgos Skoufos, Athanasios Alexiou, Maria Zioga, Spyros Tastsoglou, Filippos S. Kardaras, Nikos Perdikopanis, Zacharopoulou Elissavet, Vasileios Gouzouasis, Theodosia Charitou, Artemis G. Hatzigeorgiou   +10 more
doaj   +1 more source

Illuminating Messengers: An Update and Outlook on RNA Visualization in Bacteria

Frontiers in Microbiology, 2017
To be able to visualize the abundance and spatiotemporal features of RNAs in bacterial cells would permit obtaining a pivotal understanding of many mechanisms underlying bacterial cell biology.
Lieke A. van Gijtenbeek, Jan Kok
doaj   +1 more source

Conformational flexibility of bacterial RNA polymerase [PDF]

Proceedings of the National Academy of Sciences, 2002
The structure of Escherichia coli core RNA polymerase (RNAP) was determined by cryo-electron microscopy and image processing of helical crystals to a nominal resolution of 15 Å. Because of the high sequence conservation between the core RNAP subunits, we were able to interpret the E.
Catherine A. Richter, Seth A. Darst, Gongyi Zhang, Natacha Opalka, Pablo Chacón, Willy Wriggers, Andrey Polyakov   +6 more
openaire   +3 more sources

Alkane biosynthesis gene expression and its increased production in recombinant cyanobacteria

FEBS Open Bio, EarlyView.
The transcription and mRNA structures of the alkane biosynthesis genes ado/aar were analysed in the representative cyanobacteria PCC 6803 and SK1‐2‐1, which produce C17H36 and C15H32, respectively. PCC 6803 transconjugants carrying these genes showed a 1.8‐ to 2.3‐fold increase in C17H36 production.
Misato Nagao, Takato Ozaki, Hirofumi Fukuda, Yu Kanesaki, Munehiko Asayama   +4 more
wiley   +1 more source

A Comparison between Transcriptome Sequencing and 16S Metagenomics for Detection of Bacterial Pathogens in Wildlife. [PDF]

PLoS Neglected Tropical Diseases, 2015
BACKGROUND:Rodents are major reservoirs of pathogens responsible for numerous zoonotic diseases in humans and livestock. Assessing their microbial diversity at both the individual and population level is crucial for monitoring endemic infections and ...
Maria Razzauti, Maxime Galan, Maria Bernard, Sarah Maman, Christophe Klopp, Nathalie Charbonnel, Muriel Vayssier-Taussat, Marc Eloit, Jean-François Cosson   +8 more
doaj   +1 more source

A contact-waiting-time metric and RNA folding rates [PDF]

arXiv, 2009
Metrics for indirectly predicting the folding rates of RNA sequences are of interest. In this letter, we introduce a simple metric of RNA structural complexity, which accounts for differences in the energetic contributions of RNA base contacts toward RNA structure formation.
arxiv