Results 141 to 150 of about 384,029 (308)

Double-stranded RNA made in C. elegans neurons can enter the germline and cause transgenerational gene silencing

Proceedings of the National Academy of Sciences of the United States of America, 2015
Sindhuja Devanapally, Snusha Ravikumar, A. Jose   +2 more
semanticscholar   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

<i>Leishmania</i> RNA Virus and Its Impact on Drug Response and Clinical Outcomes in Leishmaniasis: A Comprehensive Review. [PDF]

J Parasitol Res
Zolfaghari A, Seyedyousefi S, Shahmoradi Z, Zaker E, Esboei BR.   +4 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Terminal loop sequences in viral double-stranded RNAs modulate RIG-I signaling. [PDF]

RNA
Hackbart M, Wang P, Gnazzo V, López CB.
europepmc   +1 more source

Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8

Science, 2004
F. Heil, H. Hemmi, H. Hochrein, Franziska Ampenberger, C. Kirschning, S. Akira, G. Lipford, H. Wagner, S. Bauer   +8 more
semanticscholar   +1 more source

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

Increased brightness of fluorescent uridine, qU, inside single- and double-stranded RNA. [PDF]

Sci Rep
Karlsson AFE, Pfeiffer P, Le HN, Baladi T, Dahlén A, Wilhelmsson LM.   +5 more
europepmc   +1 more source

Middle East Respiratory Syndrome Coronavirus 4a Protein Is a Double-Stranded RNA-Binding Protein That Suppresses PACT-Induced Activation of RIG-I and MDA5 in the Innate Antiviral Response

Journal of Virology, 2014
Kam-Leung Siu, M. Yeung, K. Kok, Kit-San Yuen, C. Kew, Pak-Yin Lui, Chi-Ping Chan, H. Tse, Patrick C Y Woo, K. Yuen, D. Jin   +10 more
semanticscholar   +1 more source

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Advanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian, Xuyun Peng, Zhiyong Gong, Xinyi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jinghui Guo, Geyang Xu, Qi Zhang   +14 more
wiley   +1 more source