Results 161 to 170 of about 384,029 (308)

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

Science, 2018
Janice S. Chen, E. Ma, Lucas B. Harrington, Maria Da Costa, Xinran Tian, J. Palefsky, J. Doudna   +6 more
semanticscholar   +1 more source

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Fungal small RNA: unveiling the breakthroughs and promising applications. [PDF]

Front Fungal Biol
Sun S, Situ J, Gao C, Chai Y, Lv C, Ma X, Zhang Y.   +6 more
europepmc   +1 more source

Interferon and double-stranded RNA [PDF]

Nature, 1979
John Morser, Derek Burke
openaire   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

TAV2b Peptide Derivatives Underwind and Stabilize Double-Stranded RNA upon Binding. [PDF]

J Am Chem Soc
Rashid ZM, Klein M, van Heesch T, Quack S, Smitskamp Q, America PPB, Rivas P, Albers MA, Paulus J, Vreede J, Grossmann TN, Dulin D.   +11 more
europepmc   +1 more source

A Radioresistant‐Tumor‐Targeted Nanoparticle for X‐Ray‐Controlled Nitric Oxide Release to Potentiate Radiotherapy

Advanced Science, EarlyView.
The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang, Xiaoyan Yin, Ting Wang, Hongfu Zhao, Zhipeng Zhao, Jinbao Wang, Cheng Tao, Xuanchu Ge, Yanze Li, Linlin Liu, Fuxin Xue   +10 more
wiley   +1 more source

Small RNAs as systemic signals in plant defense: mechanisms, challenges, and future directions. [PDF]

Mol Biol Rep
Wekesa C, Kiprotich K, Muoma J, Mithöfer A.   +3 more
europepmc   +1 more source

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Defects in intron recycling suppress the antiviral response via a mechanism of intronic endogenous dsRNA. [PDF]

J Exp Med
Duan C, Buerer L, Bowers C, Taggart AJ, O'Brien MH, Gunasekera S, Lin CL, Wang J, Zeng Y, Staley JP, Fredericks AM, Monaghan SF, Welch A, Clark NE, Gao D, Marr N, Zhang SY, Casanova JL, Fairbrother WG.   +18 more
europepmc   +1 more source