Results 61 to 70 of about 419,218 (304)

Engineering double-stranded RNA binding activity into the Drosha double-stranded RNA binding domain results in a loss of microRNA processing function.

PLoS ONE, 2017
Canonical processing of miRNA begins in the nucleus with the Microprocessor complex, which is minimally composed of the RNase III enzyme Drosha and two copies of its cofactor protein DGCR8.
Joshua C Kranick, Durga M Chadalavada, Debashish Sahu, Scott A Showalter   +3 more
doaj   +1 more source

A small RNA response at DNA ends in Drosophila [PDF]

, 2012
Small RNAs have been implicated in numerous cellular processes, including effects on chromatin structure and the repression of transposons. We describe the generation of a small RNA response at DNA ends in Drosophila that is analogous to the recently ...
Böttcher, Romy, Förstemann, Klaus, Michalik, Katharina M.   +2 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

TRBP and eIF6 homologue in Marsupenaeus japonicus play crucial roles in antiviral response.

PLoS ONE, 2012
Plants and invertebrates can suppress viral infection through RNA silencing, mediated by RNA-induced silencing complex (RISC). Trans-activation response RNA-binding protein (TRBP), consisting of three double-stranded RNA-binding domains, is a component ...
Shuai Wang, An-Jing Chen, Li-Jie Shi, Xiao-Fan Zhao, Jin-Xing Wang   +4 more
doaj   +1 more source

Tomato chlorosis virus CPm protein is a pathogenicity determinant and suppresses host local RNA silencing induced by single-stranded RNA

Frontiers in Microbiology, 2023
IntroductionTomato chlorosis virus (ToCV) is a typical member of the genus Crinivirus, which severely threatens Solanaceae crops worldwide. The CPm protein encoded by ToCV has been reported to be associated with virus transmission by vectors and is ...
Xiao Yang, Xiangwen Luo, Xiangwen Luo, Yu Zhang, Zhanhong Zhang, Zhanhong Zhang, Xian OuYang, Xiaobin Shi, Xiaobin Shi, Xiaoyuan Lv, Fan Li, Songbai Zhang, Songbai Zhang, Yong Liu, Yong Liu, Deyong Zhang, Deyong Zhang   +16 more
doaj   +1 more source

A deletion mutant of L-A double-stranded RNA replicates like M1 double-stranded RNA [PDF]

Journal of Virology, 1988
X double-stranded RNA (dsRNA) is a 0.52-kilobase dsRNA molecule that arose spontaneously in a nonkiller strain of Saccharomyces cerevisiae originally containing L-A and L-BC dsRNAs (L-BC is the same size as L-A but shares no homology with it). X hybridized with L-A, and direct RNA sequencing of X showed that the first 5' 25 base pairs (of the X ...
R, Esteban, R B, Wickner
openaire   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

LL-37 and Double-Stranded RNA Synergistically Upregulate Bronchial Epithelial TLR3 Involving Enhanced Import of Double-Stranded RNA and Downstream TLR3 Signaling

Biomedicines, 2022
The human host defense peptide LL-37 influences double-stranded RNA signaling, but this process is not well understood. Here, we investigate synergistic actions of LL-37 and synthetic double-stranded RNA (poly I:C) on toll-like receptor 3 (TLR3 ...
Sara Bodahl, Samuel Cerps, Lena Uller, Bengt-Olof Nilsson   +3 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

A New Model of Gastric Pre-neoplasia Induced by Aberrant ADAR1-mediated Double-stranded RNA SignalingSummaryWhat You Need to Know

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Recent evidence suggests that endogenously derived double-stranded RNA (dsRNA) impacts multiple cellular processes, although its role in epithelial injury remains understudied.
Angela M. Halstead, Chinye Nwokolo, Stella Hoft, Jinsheng Yu, Lifei Zhu, Brendan Tuley, Nancy Vargas, RuiRui Liu, Francisco Ramirez Victorino, Simrin Phatak, Wandy Beatty, Chun-Kan Chen, Richard DiPaolo, Paul Cliften, Tarin M. Bigley, José B. Sáenz   +15 more
doaj   +1 more source