Results 41 to 50 of about 2,383,057 (293)

RNA interference, growth and differentiation appear normal in African trypanosomes lacking Tudor staphylococcal nuclease. [PDF]

, 2010
Ribonucleases play important roles in the RNA interference (RNAi) pathway. The Dicer endonuclease converts double-stranded (ds)RNA into small interfering (si)RNA and the Slicer endonuclease, as a component of the RNA induced silencing complex (RISC ...
Louise E. Kemp, Kawahara, Taemi, Horn, David, Horn, David; id_orcid, Kemp, Louise E, Sam Alsford, Taemi Kawahara, Alsford, Sam, Kemp, Louise E., David Horn   +9 more
core   +1 more source

hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity [PDF]

, 2011
hSSB1 is a recently discovered single-stranded DNA binding protein that is essential for efficient repair of DNA double-strand breaks (DSBs) by the homologous recombination pathway.
Dinoop Menon, Cubeddu, Liza (R16726), Bain, Amanda, White, Malcolm F., Emma Bolderson, Urquhart, Aaron J., Aaron J. Urquhart, Bolderson, Emma, Khanna, Kum Kum, Menon, Dinoop, Derek J. Richard, Amanda Bain, Malcolm F. White, Richard, Derek J., Kum Kum Khanna, Liza Cubeddu, Cubeddu, Liza   +16 more
core   +3 more sources

LAST-seq: single-cell RNA sequencing by direct amplification of single-stranded RNA without prior reverse transcription and second-strand synthesis

Genome Biology, 2023
Existing single-cell RNA sequencing (scRNA-seq) methods rely on reverse transcription (RT) and second-strand synthesis (SSS) to convert single-stranded RNA into double-stranded DNA prior to amplification, with the limited RT/SSS efficiency compromising ...
Jun Lyu, Chongyi Chen
doaj   +1 more source

Novel endoribonucleases as central players in various pathways of eukaryotic RNA metabolism [PDF]

, 2010
For a long time it has been assumed that the decay of RNA in eukaryotes is mainly carried out by exoribonucleases, which is in contrast to bacteria, where endoribonucleases are well documented to initiate RNA degradation.
Tomecki, Rafał, Dziembowski, Andrzej
core   +3 more sources

Interaction of PKR with single-stranded RNA

Scientific Reports, 2017
Although the antiviral kinase PKR was originally characterized as a double-stranded RNA activated enzyme it can be stimulated by RNAs containing limited secondary structure.
Christopher B. Mayo, James L. Cole
doaj   +1 more source

siRNA-like double-stranded RNAs are specifically protected against degradation in human cell extract. [PDF]

PLoS ONE, 2011
RNA interference (RNAi) is a set of intracellular pathways in eukaryotes that controls both exogenous and endogenous gene expression. The power of RNAi to knock down (silence) any gene of interest by the introduction of synthetic small-interfering (si ...
John A H Hoerter, Vishalakshi Krishnan, Troy A Lionberger, Nils G Walter   +3 more
doaj   +1 more source

A Rapid Method for Sequencing Double-Stranded RNAs Purified from Yeasts and the Identification of a Potent K1 Killer Toxin Isolated from Saccharomyces cerevisiae

Viruses, 2019
Mycoviruses infect a large number of diverse fungal species, but considering their prevalence, relatively few high-quality genome sequences have been determined.
Angela M. Crabtree, Emily A. Kizer, Samuel S. Hunter, James T. Van Leuven, Daniel D. New, Matthew W. Fagnan, Paul A. Rowley   +6 more
doaj   +1 more source

Arabidopsis thaliana endonuclease V is a ribonuclease specific for inosine-containing single-stranded RNA

Open Biology, 2021
Endonuclease V is highly conserved, both structurally and functionally, from bacteria to humans, and it cleaves the deoxyinosine-containing double-stranded DNA in Escherichia coli, whereas in Homo sapiens it catalyses the inosine-containing single ...
Megumi Endo, Jung In Kim, Narumi Aoki Shioi, Shigenori Iwai, Isao Kuraoka   +4 more
doaj   +1 more source

Rotavirus infection induces transient pancreatic involution and hyperglycemia in weanling mice. [PDF]

PLoS ONE, 2014
Rotavirus is a ubiquitous double-stranded RNA virus responsible for most cases of infantile gastroenteritis. It infects pancreatic islets in vitro and is implicated as a trigger of autoimmune destruction of islet beta cells leading to type 1 diabetes ...
Margo C Honeyman, David Laine, Yifan Zhan, Sarah Londrigan, Carl Kirkwood, Leonard C Harrison   +5 more
doaj   +1 more source

Sensitivity and specificity of anti-double-stranded RNA immunofluorescence for universal detection of viral infection in respiratory specimens

Heliyon, 2021
Background: Emerging viruses could be detected before reaching pandemic level if universal viral detection screening was routinely used. Double-stranded RNA (dsRNA) is the only common antigen across most viral families.
Kornthara Kawang, Udsanee Naoudom, Ekasit Kowitdamrong, Stephen J. Kerr, Kiat Ruxrungtham, Voraphoj Nilaratanakul   +5 more
doaj   +1 more source