Results 31 to 40 of about 419,218 (304)

Interaction of PKR with single-stranded RNA

Scientific Reports, 2017
Although the antiviral kinase PKR was originally characterized as a double-stranded RNA activated enzyme it can be stimulated by RNAs containing limited secondary structure.
Christopher B. Mayo, James L. Cole
doaj   +1 more source

siRNA-like double-stranded RNAs are specifically protected against degradation in human cell extract. [PDF]

PLoS ONE, 2011
RNA interference (RNAi) is a set of intracellular pathways in eukaryotes that controls both exogenous and endogenous gene expression. The power of RNAi to knock down (silence) any gene of interest by the introduction of synthetic small-interfering (si ...
John A H Hoerter, Vishalakshi Krishnan, Troy A Lionberger, Nils G Walter   +3 more
doaj   +1 more source

2006. aasta Nobeli auhind füsioloogias ja meditsiinis [PDF]

, 2006
2006. aasta Nobeli auhinna füsioloogia ja meditsiini alal pälvisid Andrew Z. Fire ja Craig C. Mellouurimuse eest teemal “RNA interferents – geenidevaigistamine kahe ahelalise RNA abil” (“RNAinterference – gene silencing by double-stranded RNA”).
Tamm, Riin
core   +2 more sources

A Rapid Method for Sequencing Double-Stranded RNAs Purified from Yeasts and the Identification of a Potent K1 Killer Toxin Isolated from Saccharomyces cerevisiae

Viruses, 2019
Mycoviruses infect a large number of diverse fungal species, but considering their prevalence, relatively few high-quality genome sequences have been determined.
Angela M. Crabtree, Emily A. Kizer, Samuel S. Hunter, James T. Van Leuven, Daniel D. New, Matthew W. Fagnan, Paul A. Rowley   +6 more
doaj   +1 more source

Double-Stranded RNA Attenuates the Barrier Function of Human Pulmonary Artery Endothelial Cells [PDF]

, 2013
Circulating RNA may result from excessive cell damage or acute viral infection and can interact with vascular endothelial cells. Despite the obvious clinical implications associated with the presence of circulating RNA, its pathological effects on ...
A Shibamiya, A Siflinger-Birnboim, AA Birukova, AK Cardozo, Akos Heinemann, AM Lundberg, Andrea Olschewski, Attila G. Végh, B Nilius, BE Dewi, BL Jacobs, C Caspersen, C Kannemeier, C Tiruppathi, Chandran Nagaraj, Csilla Fazakas, D Torres, Diana Zabini, ET Chiang, F Aeffner, G Grynkiewicz, GM Cheng, GU Ahmmed, György Váró, Horst Olschewski, HT Ma, I Khan, I Wilhelm, Imola Wilhelm, István A. Krizbai, J Tissari, JL Harcourt, L Fischer, L Liu, M Auer-Grumbach, M Schroder, MM Szewczyk, N Pirher, NC Stowell, O Dellis, P Kumar, PR Cooper, R Malli, R Malli, R O’Callaghan, R Ross, R Sutliff, Rory Edward Morty, S Akira, S Fischer, S Fischer, S Sarkar, S Zimmer, TG Ksiazek, TM Moore, V Konya, VA Londhe, Viktoria Konya, Y Tsuji, Z Balint, Zoltán Bálint   +60 more
core   +3 more sources

Arabidopsis thaliana endonuclease V is a ribonuclease specific for inosine-containing single-stranded RNA

Open Biology, 2021
Endonuclease V is highly conserved, both structurally and functionally, from bacteria to humans, and it cleaves the deoxyinosine-containing double-stranded DNA in Escherichia coli, whereas in Homo sapiens it catalyses the inosine-containing single ...
Megumi Endo, Jung In Kim, Narumi Aoki Shioi, Shigenori Iwai, Isao Kuraoka   +4 more
doaj   +1 more source

A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection [PDF]

, 2012
The innate immune response provides the first line of defense against viruses and other pathogens by responding to specific microbial molecules. Influenza A virus (IAV) produces double-stranded RNA as an intermediate during the replication life cycle ...
Maelfait, Jonathan, Roose, Kenny, Bogaert, Pieter, Sze, Mozes, Saelens, Xavier, Pasparakis, Manolis, Carpentier, Isabelle, van Loo, Geert, Beyaert, Rudi   +8 more
core   +2 more sources

Double-Stranded RNA Resists Condensation

Physical Review Letters, 2011
Much attention has been focused on DNA condensation because of its fundamental biological importance. The recent discovery of new roles for RNA duplexes demands efficient packaging of double-stranded RNA for therapeutics. Here we report measurements of short DNA and RNA duplexes in the presence of trivalent ions.
Li, Li, Suzette A, Pabit, Steve P, Meisburger, Lois, Pollack   +3 more
openaire   +3 more sources

Rotavirus infection induces transient pancreatic involution and hyperglycemia in weanling mice. [PDF]

PLoS ONE, 2014
Rotavirus is a ubiquitous double-stranded RNA virus responsible for most cases of infantile gastroenteritis. It infects pancreatic islets in vitro and is implicated as a trigger of autoimmune destruction of islet beta cells leading to type 1 diabetes ...
Margo C Honeyman, David Laine, Yifan Zhan, Sarah Londrigan, Carl Kirkwood, Leonard C Harrison   +5 more
doaj   +1 more source

A phagocytic route for uptake of double-stranded RNA in RNAi. [PDF]

PLoS ONE, 2011
RNA interference (RNAi) has a range of physiological functions including as a defence mechanism against viruses. To protect uninfected cells in a multicellular organism, not only a cell-autonomous RNAi response is required but also a systemic one ...
João J E Rocha, Viktor I Korolchuk, Iain M Robinson, Cahir J O'Kane   +3 more
doaj   +1 more source