Results 31 to 40 of about 2,383,057 (293)
Биопрепараты: Профилактика, диагностика, лечение, 2023 Scientific relevance. Innate immune activation in the early phases of COVID-19 infection and subsequent interferon induction may help control viral replication and protect cells not yet infected with SARS-CoV-2.
G. M. Ignatyev +5 more
doaj +1 more source
Diverging affinity of tospovirus RNA silencing suppressor proteins, NSs, for various RNA duplex molecules [PDF]
, 2010 The tospovirus NSs protein was previously shown to suppress the antiviral RNA silencing mechanism in plants. Here the biochemical analysis of NSs proteins from different tospoviruses, using purified NSs or NSs containing cell extracts, is described.
Kormelink, R.J.M. +16 more
core +1 more source
Cell Reports, 2014 Double-stranded RNA (dsRNA) can function as genetic information and may have served as genomic material before the existence of DNA-based life. By developing a method to purify dsRNA, we have investigated the diversity of dsRNA in microbial populations ...
Carolyn J. Decker, Roy Parker
doaj +1 more source
Sequential packaging of RNA genomic segments during the assembly of Bluetongue virus. [PDF]
, 2014 Bluetongue virus (BTV), a member of the Orbivirus genus within the Reoviridae family, has a genome of 10 double-stranded RNA segments, with three distinct size classes.
Roy, Polly +3 more
core +1 more source
Efficiency of RNA interference is improved by knockdown of dsRNA nucleases in tephritid fruit flies [PDF]
Open Biology, 2019 RNA interference (RNAi) in insects is routinely used to ascertain gene function, but also has potential as a technology to control pest species. For some insects, such as beetles, ingestion of small quantities of double-stranded RNA (dsRNA) is able to ...
Alison Tayler +4 more
doaj +1 more source
The influence of viral RNA secondary structure on interactions with innate host cell defences [PDF]
, 2013 RNA viruses infecting vertebrates differ fundamentally in their ability to establish persistent infections with markedly different patterns of transmission, disease mechanisms and evolutionary relationships with their hosts.
Blundell, Richard +13 more
core +1 more source
LGP2 plays a critical role in sensitizing mda-5 to activation by double-stranded RNA. [PDF]
, 2013 The DExD/H box RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation associated gene-5 (mda-5) sense viral RNA in the cytoplasm of infected cells and activate signal transduction pathways that trigger the production of type I ...
Kay S Childs +16 more
core +2 more sources
Targeting mitochondrial metabolites and nucleic acids as an anti-inflammatory strategy
Frontiers in Drug Discovery, 2023 Mitochondrial metabolites and their derivatives have been the focus of recent efforts to develop new anti-inflammatory therapeutics. The widely used therapeutic agents dimethyl fumarate (DMF) and metformin have anti-inflammatory properties and have been ...
Yukun Min, Luke A. J. O’Neill
doaj +1 more source
Mismatched Double-Stranded RNA [PDF]
Drugs in R & D, 2004 Ampligen [polyI:polyC12U] is a mismatched double-stranded RNA that acts by inducing interferon production (immunomodulator) and by activating an intracellular enzyme (RNase-L) against viral RNA transcripts (antiviral). Ampligen, currently under development by Hemispherx Biopharma in the US, acts on the immunological system through T-lymphocyte ...
openaire +2 more sources
Tracking Cryptosporidium parvum by Sequence Analysis of Small Double-Stranded RNA
Emerging Infectious Diseases, 2001 We sequenced a 173-nucleotide fragment of the small double-stranded viruslike RNA of Cryptosporidium parvum isolates from 23 calves and 38 humans. Sequence diversity was detected at 17 sites.
Lihua Xiao +3 more
doaj +1 more source