Results 11 to 20 of about 1,616,912 (329)
Rapid nuclear deadenylation of mammalian messenger RNA
iScience, 2023 Summary: Poly(A) tails protect RNAs from degradation and their deadenylation rates determine RNA stability. Although poly(A) tails are generated in the nucleus, deadenylation of tails has mostly been investigated within the cytoplasm.
Jonathan Alles +3 more
doaj +1 more source
Real-Time Messenger RNA Dynamics in Bacillus subtilis
Frontiers in Microbiology, 2021 Messenger RNA molecules have been localized to different positions in cells and have been followed by time-lapse microscopy. We have used MS2-mVenus–labeled mRNA and single-particle tracking to obtain information on the dynamics of single-mRNA molecules ...
Laura Sattler, Peter L. Graumann
doaj +1 more source
HIV mRNA Vaccines—Progress and Future Paths
Vaccines, 2021 The SARS-CoV-2 pandemic introduced the world to a new type of vaccine based on mRNA encapsulated in lipid nanoparticles (LNPs). Instead of delivering antigenic proteins directly, an mRNA-based vaccine relies on the host’s cells to manufacture protein ...
Zekun Mu +2 more
doaj +1 more source
Technology in Cancer Research & Treatment, 2020 RNA-binding proteins have been associated with cancer development. The overexpression of a well-known RNA-binding protein, insulin-like growth factor 2 messenger RNA–binding protein 3, has been identified as an indicator of poor prognosis in patients ...
Jing Zhang MS +4 more
doaj +1 more source
Pseudo-messenger RNA: phantoms of the transcriptome. [PDF]
PLoS Genetics, 2006 The mammalian transcriptome harbours shadowy entities that resist classification and analysis. In analogy with pseudogenes, we define pseudo-messenger RNA to be RNA molecules that resemble protein-coding mRNA, but cannot encode full-length proteins owing
Martin C Frith +12 more
doaj +2 more sources
Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor. [PDF]
, 2016 Rocaglamide A (RocA) typifies a class of protein synthesis inhibitors that selectively kill aneuploid tumour cells and repress translation of specific messenger RNAs.
Floor, Stephen N +2 more
core +1 more source
From Viral Vaccines to Messenger RNA Vaccines
Pakistan Journal of Medicine and Dentistry, 2020 Today, the swiftness of epidemics of infectious disease is alarming. To date vaccines have been an enormous success for not only preventing but completely eradicating a number of malicious infectious disease like small pox, rubella, mumps, measles and ...
Saeeda Baig, Zoha Asghar
doaj +1 more source
Technology in Cancer Research & Treatment, 2020 This study was designed to identify novel circular RNAs and the related regulatory axis to provide research targets for the diagnosis and treatment of breast cancer.
Ziqi Peng BM, Boyang Xu BM, Feng Jin MD
doaj +1 more source
Vaccines against Coronavirus Type 19: An Overview [PDF]
Al-Anbar Medical Journal, 2023 Vaccines are biological agents that provide immunity against certain diseases [1]. Vaccination is an effective technique for prevention of infection and control outbreak of a wide range of infectious diseases (https://apps.who.int/iris/handle/10665 ...
Makwan Abdulkareem
doaj +1 more source
Hepatitis C virus 3'UTR regulates viral translation through direct interactions with the host translation machinery. [PDF]
, 2013 The 3' untranslated region (3'UTR) of hepatitis C virus (HCV) messenger RNA stimulates viral translation by an undetermined mechanism. We identified a high affinity interaction, conserved among different HCV genotypes, between the HCV 3'UTR and the host ...
Bai, Yun +2 more
core +2 more sources