Results 31 to 40 of about 1,347,350 (288)

Eukaryotic translation initiation factors and cancer

open access: yesTumor Biology, 2017
Recent technological advancements have shown tremendous mechanistic accomplishments in our understanding of the mechanism of messenger RNA translation in eukaryotic cells.
Muhammad Umar Ali   +3 more
doaj   +1 more source

Mechanisms of alternative pre-messenger RNA splicing.

open access: yesAnnual Review of Biochemistry, 2003
Alternative pre-mRNA splicing is a central mode of genetic regulation in higher eukaryotes. Variability in splicing patterns is a major source of protein diversity from the genome.
D. Black
semanticscholar   +1 more source

Processivity and coupling in messenger RNA transcription.

open access: yesPLoS ONE, 2010
BackgroundThe complexity of messenger RNA processing is now being uncovered by experimental techniques that are capable of detecting individual copies of mRNA in cells, and by quantitative real-time observations that reveal the kinetics.
Stuart Aitken   +5 more
doaj   +1 more source

A thermostable messenger RNA based vaccine against rabies. [PDF]

open access: yesPLoS Neglected Tropical Diseases, 2017
Although effective rabies virus vaccines have been existing for decades, each year, rabies virus infections still cause around 50.000 fatalities worldwide. Most of these cases occur in developing countries, where these vaccines are not available.
Lothar Stitz   +8 more
doaj   +1 more source

RNA-sequencing analysis reveals the long noncoding RNA profile in the mouse myopic retina

open access: yesFrontiers in Genetics, 2022
Aim: Myopia is a prevalent public health problem. The long noncoding RNA (lncRNA) mechanisms for dysregulated retinal signaling in the myopic eye have remained elusive.
Yuanjun Li   +29 more
doaj   +1 more source

The messenger: the structure of RNA [PDF]

open access: yesBiochemical Journal, 2006
In the early part of the 20th Century, the nature of nucleic acid and what its role was within the cell were a bit of a mystery. DNA itself was first isolated as far back as 1869 by the Swiss chemist Johann Friedrich Miescher. He separated nuclei from the cytoplasm of cells and then isolated an acidic substance from these nuclei that he called nuclein1.
openaire   +2 more sources

Splicing of Messenger RNA Precursors

open access: yesCold Spring Harbor Symposia on Quantitative Biology, 1987
A general mechanism for the splicing of nuclear messenger RNA precursors in eukaryotic cells has been widely accepted. This mechanism, which generates lariat RNAs possessing a branch site, seems related to the RNA-catalyzed reactions of self-splicing introns.
Sharp, P. A.   +5 more
openaire   +8 more sources

Rapid nuclear deadenylation of mammalian messenger RNA

open access: yesiScience, 2023
Summary: Poly(A) tails protect RNAs from degradation and their deadenylation rates determine RNA stability. Although poly(A) tails are generated in the nucleus, deadenylation of tails has mostly been investigated within the cytoplasm.
Jonathan Alles   +3 more
doaj  

The Limitless Future of RNA Therapeutics

open access: yesFrontiers in Bioengineering and Biotechnology, 2021
Recent advances in the generation, purification and cellular delivery of RNA have enabled development of RNA-based therapeutics for a broad array of applications.
T. Damase   +5 more
semanticscholar   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

open access: yesMolecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever   +1 more
wiley   +1 more source

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