Bifunctional transfer-messenger RNA [PDF]
Biochimie, 2011 Transfer-messenger RNA (tmRNA) is a bifunctional RNA that has properties of a tRNA and an mRNA. tmRNA uses these two functions to release ribosomes stalled during translation and target the nascent polypeptides for degradation. This concerted reaction, known as trans-translation, contributes to translational quality control and regulation of gene ...
Kenneth C, Keiler, Nitya S, Ramadoss
openaire +2 more sources
A thermostable messenger RNA based vaccine against rabies. [PDF]
PLoS Neglected Tropical Diseases, 2017 Although effective rabies virus vaccines have been existing for decades, each year, rabies virus infections still cause around 50.000 fatalities worldwide. Most of these cases occur in developing countries, where these vaccines are not available.
Lothar Stitz +8 more
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Processivity and coupling in messenger RNA transcription.
PLoS ONE, 2010 BackgroundThe complexity of messenger RNA processing is now being uncovered by experimental techniques that are capable of detecting individual copies of mRNA in cells, and by quantitative real-time observations that reveal the kinetics.
Stuart Aitken +5 more
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Interplay of 'induced fit' and preorganization in the ligand induced folding of the aptamer domain of the guanine binding riboswitch [PDF]
, 2006 Riboswitches are highly structured elements in the 50-untranslated regions (50-UTRs) of messenger RNA that control gene expression by specifically binding to small metabolite molecules. They consist of an aptamer domain responsible for ligand binding and
Noeske, Jonas +5 more
core +1 more source
Guardian of Genetic Messenger-RNA-Binding Proteins
Biomolecules, 2016 RNA in cells is always associated with RNA-binding proteins that regulate all aspects of RNA metabolism including RNA splicing, export from the nucleus, RNA localization, mRNA turn-over as well as translation. Given their diverse functions, cells express
Antje Anji, Meena Kumari
doaj +1 more source
Stochastic Modeling of Expression Kinetics Identifies Messenger Half-Lives and Reveals Sequential Waves of Co-ordinated Transcription and Decay [PDF]
, 2012 The transcriptome in a cell is finely regulated by a large number of molecular mechanisms able to control the balance between mRNA production and degradation. Recent experimental findings have evidenced that fine and specific regulation of degradation is
Cacace, Filippo +4 more
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Eukaryotic translation initiation factors and cancer
Tumor Biology, 2017 Recent technological advancements have shown tremendous mechanistic accomplishments in our understanding of the mechanism of messenger RNA translation in eukaryotic cells.
Muhammad Umar Ali +3 more
doaj +1 more source
RNA-sequencing analysis reveals the long noncoding RNA profile in the mouse myopic retina
Frontiers in Genetics, 2022 Aim: Myopia is a prevalent public health problem. The long noncoding RNA (lncRNA) mechanisms for dysregulated retinal signaling in the myopic eye have remained elusive.
Yuanjun Li +29 more
doaj +1 more source
LTD4 and TGF-β1 induce the expression of metalloproteinase-1 in chronic rhinosinusitis via a cysteinyl leukotriene receptor 1-related mechanism [PDF]
, 2016 A
Bachert, Claus +4 more
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Klotho mice: a novel wound model of aged skin. [PDF]
, 2014 BackgroundAs the elderly population continues to expand, it becomes increasingly important to develop treatments to improve wound healing in the elderly.
Yamashita, Ken +3 more
core +2 more sources