Results 171 to 180 of about 129,806 (287)

Research Techniques Made Simple: Bacterial 16S Ribosomal RNA Gene Sequencing in Cutaneous Research.

open access: yesJournal of Investigative Dermatology, 2016
J. Jo, Elizabeth A. Kennedy, H. Kong
semanticscholar   +1 more source

Mammalian Tolerance to Amino Acid Heterochirality

open access: yesChemBioChem, Accepted Article.
Organisms use amino acids predominantly in l‐configuration. On the other hand, a series of studies show that a variety of d‐amino acids also occur in mammals and amino acid homochirality is not complete. Mammals de novo synthesize most amino acids with l‐configuration, but serine and aspartate are converted from l‐ to d‐configuration by endogenous ...
Jumpei Sasabe   +4 more
wiley   +1 more source

Comparison of RNA- and DNA-based 16S amplicon sequencing to find the optimal approach for the analysis of the uterine microbiome. [PDF]

open access: yesSci Rep
Dyroff AI   +6 more
europepmc   +1 more source

Peptidomimetics Targeting the Amyloidogenicity of Nucleophosmin 1 Mutations in Acute Myeloid Leukemia

open access: yesChemBioChem, Accepted Article.
Nucleophosmin 1(NPM1) is an abundant human protein endowed with many functions whose dysregulation leads to various cancers and mutations are relevant in Acute Myeloid Leukemia (AML). In the wild type form, pentameric NPM1 resides mainly in the nucleolus even if it shuttles toward the cytosol exerting its chaperon function, conversely in AML‐mutated ...
Daniele Florio   +7 more
wiley   +1 more source

Biosynthesis of the Fungal Cyclic Lipodepsipeptide Pleosporacin, a New Selective Inhibitor of the Phytopathogen Botrytis cinerea

open access: yesChemBioChem, EarlyView.
Bioactivity‐guided isolation led to the discovery of a potent and selective inhibitor of the phytopathogen Botrytis cinerea, pleosporacin (1), from mycelia extracts of the fungal strain Pleosporales sp. IBWF 020‐21. The biosynthesis of the nonribosomal cyclic lipodepsipeptide 1 was elucidated via heterologous reconstitution in Aspergillus oryzae ...
Carsten Wieder   +6 more
wiley   +1 more source

Advancing the Exploration of the Ubiquitin‐like Protein FUBI with Synthetic Chemical Tools

open access: yesChemBioChem, Accepted Article.
The Ubiquitin‐like protein FUBI is encoded in humans by the FAU gene, whose down‐regulation in prostate, ovarian and breast cancer is significantly associated with poor prognosis. Despite its implications in disease progression, the regulatory mechanisms orchestrated by FUBI remain elusive. To address this knowledge gap, we developed a linear synthetic
Francesca D'Amico   +8 more
wiley   +1 more source

Advances in Isotope Labeling for Solution Nucleic Acid Nuclear Magnetic Resonance Spectroscopy

open access: yesChemPlusChem, EarlyView.
Recent advances in the field of nucleic acid nuclear magnetic resonance (NMR) are presented. Stable isotope labeling protocols and new approaches to segmentally label nucleic acid with NMR‐active residues are summarized. The novel methods will have a strong impact on the future of nucleic acid NMR and the characterization of structure and dynamics of ...
Stefan Hilber   +3 more
wiley   +1 more source

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