Results 231 to 240 of about 126,755 (277)

C‐X‐C chemokine receptor CXCR4 mediates diurnal changes in the aggregation and dispersion of CD8+ T cells within the tumor microenvironment

open access: yesInternational Journal of Cancer, EarlyView.
What's New? In addition to governing daily variations in biological activity, the circadian clock regulates immune cell migration into tumors. Whether this influence extends to immune cell localization within the tumor microenvironment (TME) is unknown. Here, using cell and animal models, the authors investigated immune cell distribution within the TME
Akito Tsuruta   +10 more
wiley   +1 more source

The hidden regulators: Non‐coding RNAs in KMT2A‐rearranged acute lymphoblastic leukemia

open access: yesInternational Journal of Cancer, EarlyView.
Abstract Acute lymphoblastic leukemia (ALL) driven by KMT2A rearrangements (KMT2A‐r) is an aggressive hematologic malignancy with poor prognosis and a high incidence in infants. While KMT2A fusion proteins drive leukemogenesis through transcriptional dysregulation, recent discoveries have highlighted the pivotal role of non‐coding RNAs (ncRNAs) in ...
Maria Augusta Poersch   +5 more
wiley   +1 more source

Circulation characteristics of bat coronaviruses linked to bat ecological factors in Korea, 2021-2022. [PDF]

open access: yesVirulence
Kim MC   +13 more
europepmc   +1 more source

A Dual Action of Everolimus in Ulcerative Colitis: Blocking CLEC4E‐Driven Inflammation and Remodeling the Gut Microbiota‐Metabolite Axis

open access: yesiMetaMed, EarlyView.
Graphical abstract of the major mechanisms of Everolimus in ulcerative colitis: Everolimus, a selective mTORC1 inhibitor, protects against ulcerative colitis through a dual mechanism. First, Eve directly suppresses CLEC4E/Syk/NF‐κB signaling, thereby reducing pro‐inflammatory cytokine production and preserving intestinal barrier integrity.
Jing Chen   +6 more
wiley   +1 more source

Metagenomics and digital cell modeling facilitate targeted high‐throughput sorting of anaerobic hydrogen‐producing microorganisms

open access: yesiMeta, EarlyView.
This study proposes a novel strategy that prioritizes functional recognition, followed by targeted high‐throughput sorting, to enable the comprehensive, rapid, and efficient acquisition of target microorganisms. Using metagenomic sequencing and binning analysis, we identified 215 potential anaerobic hydrogen‐producing strains from 12 large‐scale biogas
Jianfeng Liu   +15 more
wiley   +1 more source

Unlocking River Biofilm Microbial Diversity: A Comparative Analysis of Sequencing Technologies. [PDF]

open access: yesMol Ecol Resour
Anderson MAJ   +6 more
europepmc   +1 more source

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