Results 71 to 80 of about 133,666 (284)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

MOLECULAR IDENTIFICATION OF SEVERAL CLINICALLYIMPORTANT BACTERIA INCLUDING ENTEROBACTERIA BYPARTIAL 16S RIBOSOMAL RNA GENE SEQUENCE COMPARISON

Zdravniški Vestnik, 2008
BACKGROUND The correct identification of bacterial isolates is paramount for the correct diagnosis andtreatment of patients. The standard approach for bacterial identification relies on phenotypic tests, which are often time-consuming and unreliable when
Janez Šimenc, Andrej Golle, Uroš Potočnik   +2 more
doaj  

Aneurysm Infection Caused by Desulfovibrio desulfuricans

Emerging Infectious Diseases, 2023
An 84-year-old man in Japan who had undergone endovascular aortic repair 9 years earlier had an infected aneurysm develop. We detected Desulfovibrio desulfuricans MB at the site.
Tatsuya Fujihara, Keigo Kimura, Hiroo Matsuo, Ryuichi Minoda Sada, Shigeto Hamaguchi, Go Yamamoto, Takuya Yamakura, Satoshi Kutsuna   +7 more
doaj   +1 more source

The newest Oxford Nanopore R10.4.1 full-length 16S rRNA sequencing enables the accurate resolution of species-level microbial community profiling

Applied and Environmental Microbiology, 2023
The long-read amplicon provides a species-level solution for the community. With the improvement of nanopore flowcells, the accuracy of Oxford Nanopore Technologies (ONT) R10.4.1 has been substantially enhanced, with an average of approximately 99%.
Tianyuan Zhang, Hanzhou Li, Silin Ma, Jian Cao, Hao Liao, Qiaoyun Huang, Wenli Chen   +6 more
semanticscholar   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

The oral microbiome of patients with ischemic stroke predicts their severity and prognosis

Frontiers in Immunology, 2023
Background and objectivesStroke is a common group of cerebrovascular diseases that can lead to brain damage or death. Several studies have shown a close link between oral health and stroke.
Wenbo Sun, Shengwen Huang, Xiaoli Yang, Yufan Luo, Luqiong Liu, Danhong Wu   +5 more
doaj   +1 more source

A systematic search for discriminating sites in the 16S ribosomal RNA gene [PDF]

Microbial Informatics and Experimentation, 2014
The 16S rRNA is by far the most common genomic marker used for prokaryotic classification, and has been used extensively in metagenomic studies over recent years. Along the 16S gene there are regions with more or less variation across the kingdom of bacteria.
Vinje, Hilde, Almøy, Trygve, Liland, Kristian Hovde, Snipen, Lars   +3 more
openaire   +4 more sources

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Predominance of Leptospira wolffii in north-central Bangladesh, 2019

New Microbes and New Infections, 2020
Leptospira was detected in 48.9% of blood samples from 182 febrile patients in north-central Bangladesh in 2019. Most Leptospira were classified as L.
S. Rahman, S.K. Paul, M.S. Aung, S. Ahmed, N. Haque, M.N.I. Raisul, J.K. Choity, S.S. Nila, H. Ara, S. Roy, M.N.A.A. Khan, M.A. Hossain, N. Kobayashi   +12 more
doaj   +1 more source

Novel and Efficient Method for Diagnosing Infective Endocarditis Using 16S Ribosomal RNA Gene Amplicon Sequence

JACC: Case Reports, 2023
We present 2 cases that both developed infective endocarditis and underwent mitral valve replacement. In addition to positive blood culture and echocardiographic findings, such as vegetation or mitral valve perforation, the 16S ribosomal RNA gene ...
Akihisa Kataoka, MD, PhD, Takahiko Shiba, DDS, PhD, Sayaka Katagiri, DDS, PhD, Shuhei Koyama, MD, Kento Kito, MD, Tatsuya Ota, MD, Taiga Katayama, MD, PhD, Yujin Ohsugi, DDS, PhD, Takahiko Nagai, DDS, Ryota Kobayashi, DDS, Keiji Komatsu, DDS, PhD, Masahiro Urata, MD, Tomohiro Imazuru, MD, PhD, Takanori Iwata, DDS, PhD, Ken Kozuma, MD, PhD   +14 more
doaj   +1 more source