Results 181 to 190 of about 77,694 (290)

Long noncoding RNA GCH1 mediates mitophagy via the PTEN‐induced kinase 1/Parkin pathway to drive chondrocyte dysfunction and cartilage degeneration in osteoarthritis

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract illustrates the role of lncRNA‐GCH1 in regulating mitophagy and its downstream effects on chondrocyte dysfunction and cartilage degradation in osteoarthritis (OA). Elevated lncRNA‐GCH1 stabilizes PINK1 protein, enhancing mitophagy and mitochondrial turnover.
Gang Zeng, Yujun Sun, Taihe Liu, Wenzhou Liu, Yanbo Chen, Jionglin Wu, Jiayuan Zheng, Weidong Song, Yue Ding   +8 more
wiley   +1 more source

Protein Functional Effector (pfe) Noncoding RNAS Are Identical to Fragments from Various Noncoding RNAs. [PDF]

Int J Mol Sci
Patarca R, Haseltine WA.
europepmc   +1 more source

The FindMNDBiomarker Program: Protein Changes in Motor Neuron Disease/Amyotrophic Lateral Sclerosis Postmortem Tissue and Biofluids

Annals of Neurology, EarlyView.
Objective Biomarkers of disease pathogenesis are critically needed for amyotrophic lateral sclerosis (ALS) to facilitate diagnosis and patient stratification into appropriate therapeutic trials. Proteomic studies offer significant potential to advance this, but reproducibility across laboratories is a key component toward identifying protein changes ...
Gabrielle L. Adler, Matthew C. Kiernan, Rachel H. Tan   +2 more
wiley   +1 more source

Potential Application of a Water‐Soluble Fullerene C60 Decorated with Diethylene Glycol in Treatment of Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
A new ethoxyethanol derivative of iminofullerene, F2, is synthesized and labeled with 99mTc to produce 99mTc‐F2. In vitro, compound F2 inhibits the activation of primary mouse bone marrow‐derived macrophages stimulated with lipopolysaccharide. Moreover, 99mTc‐F2 is selectively enriched in the injured joints of mice. Inflammatory macrophages play a role
Rui He, Alyssa Costello, Yanjie Liu, Weicheng Wang, Zhichang Zhang, Quanjun Cui, Xinlin Yang   +6 more
wiley   +1 more source

Exploring the roles of snoRNA-induced ribosome heterogeneity in equine osteoarthritis. [PDF]

Front Vet Sci
Chabronova A, Walters M, Regårdh S, Jacobsen S, Bundgaard L, Anderson JR, Peffers MJ.   +6 more
europepmc   +1 more source

Harnessing Physiological Shear Stress in a Perfusion Bioreactor for Enhanced Endothelialization of Small‐Diameter Vascular Grafts

Advanced NanoBiomed Research, EarlyView.
Traditional static culture provides limited physiological relevance for evaluation of vascular grafts. A perfusion bioreactor system can provide more accurate in vitro model for evaluation of vascular grafts, exposing endothelial cells on 3D structure to physiological or pathological shear stress.
Praveesuda L. Michael, Yuen Ting Lam, Timothy C. Mitchell, Miguel Santos, Alex H. P. Chan, Xinying Liu, Angus J. Grant, Matthew J. Moore, David F. Fletcher, Richard P. Tan, Steven G. Wise   +10 more
wiley   +1 more source

Overreliance on Plasmodium 18S rRNA gene for malaria molecular diagnosis-inferences from systematic review. [PDF]

Malar J
Deora N, Khan MR, Singh P, Zehra N, Sircar S, Pande V, Mallick PK, Sinha A.   +7 more
europepmc   +1 more source

Genomic Insights Into a Strong Biofilm‐Forming Enterococcus faecalis MTR_EFS01 Strain Isolated From a Shrimp in Bangladesh

Animal Research and One Health, EarlyView.
This study characterizes a multidrug‐resistant and strong biofilm‐forming Enterococcus faecalis strain obtained from a shrimp sample in Bangladesh. ABSTRACT Enterococcus faecalis is known for its ability to form strong biofilms and its role as an opportunistic pathogen. In this study, we screened and characterized a multidrug‐resistant (MDR) and strong
Md. Ashek Ullah, Md. Saiful Islam, Md. Liton Rana, Jayedul Hassan, Md. Tanvir Rahman   +4 more
wiley   +1 more source

Extracellular rRNA Profiling Reveals the Sinking and Cell Lysis Dynamics of Marine Microeukaryotes. [PDF]

Environ Microbiol
Endo H, Yamagishi Y, Nguyen TT, Ogata H.
europepmc   +1 more source

Decoding Ribosome Stress: How NAT10 Influences Pancreatic Acinar Cell Survival and Cancer Development. [PDF]

Cell Mol Gastroenterol Hepatol
Bailey-Lundberg JM.
europepmc   +1 more source