Results 31 to 40 of about 69,537 (283)

Dissemination of -mediated linezolid resistance among species isolated from a teaching hospital in Beijing, China

Journal of International Medical Research, 2018
Objective The aim of the present study was to report the dissemination of cfr and fexA genes mediated by linezolid resistance among Staphylococcus species.
Jiyong Jian, Liang Chen, Zeqiang Xie, Man Zhang   +3 more
doaj   +1 more source

Rapid Acquisition of Linezolid Resistance in Methicillin-Resistant Staphylococcus aureus: Role of Hypermutation and Homologous Recombination.

PLoS ONE, 2016
BackgroundWe previously reported the case of a 64-year-old man with mediastinitis caused by Staphylococcus aureus in which the infecting bacterium acquired linezolid resistance after only 14 days treatment with linezolid.
Shigekazu Iguchi, Tomonori Mizutani, Keiichi Hiramatsu, Ken Kikuchi   +3 more
doaj   +1 more source

Point Deletion or Insertion in CmeR-Box, A2075G Substitution in 23S rRNA, and Presence of erm(B) Are Key Factors of Erythromycin Resistance in Campylobacter jejuni and Campylobacter coli Isolated From Central China

Frontiers in Microbiology, 2020
Campylobacter jejuni and Campylobacter coli are major food-borne pathogens that cause bacterial gastroenteritis in humans, and poultry is considered as their most important reservoir.
Yiluo Cheng, Wenting Zhang, Qin Lu, Guoyuan Wen, Zhongzheng Zhao, Qingping Luo, Huabin Shao, Tengfei Zhang   +7 more
doaj   +1 more source

Structure Prediction of RNA Loops with a Probabilistic Approach. [PDF]

PLoS Computational Biology, 2016
The knowledge of the tertiary structure of RNA loops is important for understanding their functions. In this work we develop an efficient approach named RNApps, specifically designed for predicting the tertiary structure of RNA loops, including hairpin ...
Jun Li, Jian Zhang, Jun Wang, Wenfei Li, Wei Wang   +4 more
doaj   +1 more source

Pyrosequencing Assay to Rapidly Detect Clarithromycin Resistance Mutations in Canadian Helicobacter pylori Isolates

Canadian Journal of Gastroenterology, 2009
BACKGROUND: Mutations at positions 2142 or 2143 in the two-copy 23S ribosomal RNA gene of Helicobacter pylori are highly predictive of in vitro clarithromycin resistance and failure of clarithromycin-containing treatment regimens.
R Slinger, L Yan, F Chan, K Forward, G Cooper-Lesins, L Best, D Haldane, S Veldhuyzen van Zanten   +7 more
doaj   +1 more source

The 70S Escherichia coli ribosome at 23 å resolution: fitting the ribosomal RNA [PDF]

Structure, 1995
The ribosome--essential for protein synthesis in all organisms--has been an evasive target for structural studies. The best available structures for the 70S Escherichia coli ribosome or its 30S and 50S subunits are based on electron microscopical tilt experiments and are limited in resolution to 28-55 A.
Stark, Holger, Mueller, Florian, Orlova, Elena V., Schatz, Michael, Dube, Prakash, Erdemir, Tarik, Zemlin, Friedrich, Brimacombe, Richard, Heel, Marin van   +8 more
openaire   +3 more sources

Hfq and RNase R Mediate rRNA Processing and Degradation in a Novel RNA Quality Control Process

mBio, 2020
RNA quality control pathways are critical for cell survival. Here, we describe a new surveillance process involved in the degradation of highly structured and stable ribosomal RNAs.
Ricardo F. dos Santos, José M. Andrade, Joana Pissarra, Murray P. Deutscher, Cecília M. Arraiano   +4 more
doaj   +1 more source

Universal and domain-specific sequences in 23S–28S ribosomal RNA identified by computational phylogenetics

RNA: A publication of the RNA Society, 2015
Comparative analysis of ribosomal RNA (rRNA) sequences has elucidated phylogenetic relationships. However, this powerful approach has not been fully exploited to address ribosome function. Here we identify stretches of evolutionarily conserved sequences,
Stephen M. Doris, D. Smith, Julia Beamesderfer, Benjamin J. Raphael, Judith A Nathanson, S. Gerbi   +5 more
semanticscholar   +1 more source

Modifications in Thermus thermophilus 23 S Ribosomal RNA Are Centered in Regions of RNA-RNA Contact [PDF]

Journal of Biological Chemistry, 2006
Ribosomal RNA from all organisms contains post-transcriptionally modified nucleotides whose function is far from clear. To gain insight into the molecular interactions of modified nucleotides, we investigated the modification status of Thermus thermophilus 5 S and 23 S ribosomal RNA by mass spectrometry and chemical derivatization/primer extension.
Mengel-Jorgensen, J., Jensen, S.S., Rasmussen, A., Poehlsgaard, J., Iversen, J.J.L., Kirpekar, F.   +5 more
openaire   +4 more sources

Differences in 23S ribosomal RNA mutations between wild-type and mutant macrolide-resistant Chlamydia trachomatis isolates.

Experimental and Therapeutic Medicine, 2015
The aim of the present study was to determine the in vitro susceptibility of wild-type and mutant clinical isolates of Chlamydia (C.) trachomatis strains to erythromycin, azithromycin and josamycin, and to identify the resistance-conferring 23S ribosomal
Yong Jiang, Huifang Zhu, Lina Yang, Yuanjun Liu, Shuping Hou, M. Qi, Quanzhong Liu   +6 more
semanticscholar   +1 more source