Results 71 to 80 of about 69,537 (283)

Bacterial 23S Ribosomal RNA, a Ligand for Toll-like Receptor 13

, 2012
Toll-like receptors are required for detection of pathogen-associated molecular patterns and play critical roles in protection of host from infection.
Zahid Manzoor, Y. Koh
semanticscholar   +1 more source

A method for direct mass spectrometry-based identification of mono-methylated RNA nucleoside positional isomers and its application to the analysis of Leishmania ribosomal RNA.

Analytical Chemistry, 2019
RNA post-transcriptional modifications are common in all kingdoms of life, and are predominantly affiliated with methylations at various nucleobase positions.
H. Nakayama, Y. Yamauchi, Yuko Nobe, Ko Sato, N. Takahashi, M. Shalev-Benami, T. Isobe, M. Taoka   +7 more
semanticscholar   +1 more source

A novel partial modification at C2501 in Escherichia coli 23S ribosomal RNA [PDF]

RNA, 2004
Escherichia coli is the best-characterized organism with respect to posttranscriptional modifications of its ribosomal RNA (rRNA). It is presently believed that all the modified nucleotides have been identified, primarily on the basis of two detection methods; modification-induced inhibition of the enzyme reverse transcriptase or analysis by combined ...
Andersen, Thomas, Porse, Bo Torben, Kirpekar, Finn   +2 more
openaire   +4 more sources

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Real-Time Polymerase Chain Reaction for the Detection of Helicobacter pylori and Clarithromycin Resistance

Gut and Liver, 2023
Background/Aims: Real-time polymerase chain reaction (RT-PCR) is a fast and simple method for the simultaneous detection of clarithromycin (CLR) resistance and Helicobacter pylori.
Jin Hee Noh, Ji Yong Ahn, Jene Choi, Young Soo Park, Hee Kyong Na, Jeong Hoon Lee, Kee Wook Jung, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung, Jung Mogg Kim   +12 more
doaj   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

Contribution of protein Gar1 to the RNA-guided and RNA-independent rRNA:Ψ-synthase activities of the archaeal Cbf5 protein

Scientific Reports, 2018
Archaeal RNA:pseudouridine-synthase (PUS) Cbf5 in complex with proteins L7Ae, Nop10 and Gar1, and guide box H/ACA sRNAs forms ribonucleoprotein (RNP) catalysts that insure the conversion of uridines into pseudouridines (Ψs) in ribosomal RNAs (rRNAs ...
Ryosuke Fujikane, Isabelle Behm-Ansmant, Anne-Sophie Tillault, Christine Loegler, Valérie Igel-Bourguignon, Evelyne Marguet, Patrick Forterre, Christiane Branlant, Yuri Motorin, Bruno Charpentier   +9 more
doaj   +1 more source

A missense mutation of plastid RPS4 is associated with chlorophyll deficiency in Chinese cabbage (Brassica campestris ssp. pekinensis)

BMC Plant Biology, 2018
Background Plastome mutants are ideal resources for elucidating the functions of plastid genes. Numerous studies have been conducted for the function of plastid genes in barley and tobacco; however, related information is limited in Chinese cabbage ...
Xiaoyan Tang, Yiheng Wang, Yun Zhang, Shengnan Huang, Zhiyong Liu, Danli Fei, Hui Feng   +6 more
doaj   +1 more source

Unveiling the structural features that determine the dual methyltransferase activities of Streptococcus pneumoniae RlmCD. [PDF]

PLoS Pathogens, 2018
Methyltransferase RlmCD was previously shown to be responsible for the introduction of C5 methylation at both U747 and U1939 of the 23S ribosomal RNA in Streptococcus pneumoniae.
Yiyang Jiang, Hailong Yu, Fudong Li, Lin Cheng, Lingru Zhu, Yunyu Shi, Qingguo Gong   +6 more
doaj   +1 more source

The binding site for ribosomal protein L2 within 23S ribosomal RNA of Escherichia coli. [PDF]

The EMBO Journal, 1988
Ribosomal protein L2 from Escherichia coli binds to and protects from nuclease digestion a substantial portion of 'domain IV' of 23S rRNA. In particular, oligonucleotides derived from the sequence 1757-1935 were isolated and shown to rebind specifically to protein L2 in vitro. Other L2-protected oligonucleotides, also derived from domain IV (i.e.
A A, Beauclerk, E, Cundliffe
openaire   +2 more sources