Results 121 to 130 of about 86,320 (269)
Reference genes for real-time PCR quantification of microRNAs and messenger RNAs in rat models of hepatotoxicity. [PDF]
PLoS ONE, 2012 Hepatotoxicity is associated with major changes in liver gene expression induced by xenobiotic exposure. Understanding the underlying mechanisms is critical for its clinical diagnosis and treatment.
María N Lardizábal +5 more
doaj +1 more source
Site‐Selective Modification and Labeling of Native RNA
Chemistry – A European Journal, Volume 31, Issue 12, February 25, 2025.The review highlights recent advancements in site‐selective modification and labeling of native RNA, an important area for the development of RNA therapeutics and fundamental RNA research. The applications, current challenges of existing methods and potential future direction of this field are also discussed.
Tuan‐Khoa Kha, Yiran Zhao, Ru‐Yi Zhu
wiley +1 more source
Leveraging Transcriptional Signatures of Diverse Stressors for Bumble Bee Conservation
Molecular Ecology, Volume 34, Issue 3, February 2025.ABSTRACT Organisms in nature are subjected to a variety of stressors, often simultaneously. Foremost among stressors of key pollinators are pathogens, poor nutrition and climate change. Landscape transcriptomics can be used to decipher the relative role of stressors, provided there are unique signatures of stress that can be reliably detected in field ...
Gabriela M. Quinlan +2 more
wiley +1 more source
Nuclear RNA Surveillance in \u3cem\u3eSaccharomyces cerevisiae\u3c/em\u3e: Trf4p-dependent Polyadenylation of Nascent Hypomethylated tRNA and an Aberrant Form of 5S rRNA [PDF]
, 2006 1-Methyladenosine modification at position 58 of tRNA is catalyzed by a two-subunit methyltransferase composed of Trm6p and Trm61p in Saccharomyces cerevisiae.
Anderson, James T. +2 more
core +1 more source
Extraction of total RNA from single-oocytes and single-cell mRNA sequencing of swine oocytes
BMC Research Notes, 2018 Objective Analyses of single oocytes are essential for a fine dissection of molecular features governing developmental competence. We adapted the phenol–chloroform procedure for the purification of total RNA from single oocytes. Results Key modifications
Katelyn M. Kimble +2 more
doaj +1 more source
Keep calm and reboot – how cells restart transcription after DNA damage and DNA repair
FEBS Letters, Volume 599, Issue 2, Page 275-294, January 2025.DNA damage not only inhibits transcription but also disrupts nucleolar architecture. Upon DNA repair, it is crucial to restore RNA polymerase 1 and 2 transcription as well as nucleolar structure for cell survival. However, the mechanisms for reinstating them are complex and involve various proteins and processes that are still not fully understood ...
Lise‐Marie Donnio +1 more
wiley +1 more source
RNA Biology, 2020 The ribosomal RNA (rRNA) genes are generally organized as an operon and cotranscribed into a polycistronic precursor; therefore, processing and maturation of pre-rRNAs are essential for ribosome biogenesis.
Lei S. Qi +4 more
semanticscholar +1 more source
ACR Open Rheumatology, Volume 7, Issue 1, January 2025.Objective Osteoarthritis (OA) is the most common cause of chronic disability in joints among older individuals. The primary goal of OA treatment is pain relief to improve the quality of life. Inflammation and aging are involved in the pathogenesis of pain in OA. In this study, we evaluated the ability of metformin to regulate microRNAs, such as miR‐451
Nahid Alimoradi +3 more
wiley +1 more source
BMC Plant Biology, 2010 Background In flowering plants and animals the most common ribosomal RNA genes (rDNA) organisation is that in which 35S (encoding 18S-5.8S-26S rRNA) and 5S genes are physically separated occupying different chromosomal loci.
Garcia Sònia +3 more
doaj +1 more source
CoFold: thermodynamic RNA structure prediction with a kinetic twist [PDF]
arXiv, 2012 Existing state-of-the-art methods that take a single RNA sequence and predict the corresponding RNA secondary-structure are thermodynamic methods. These predict the most stable RNA structure, but do not consider the process of structure formation. We have by now ample experimental and theoretical evidence, however, that sequences in vivo fold while ...
arxiv