Results 51 to 60 of about 1,352,832 (329)
Molecules, 2011 Ribosomal RNA is the catalytic portion of ribosomes, and undergoes a variety of conformational changes during translation. Structural changes in ribosomal RNA can be facilitated by the presence of modified nucleotides. Helix 31 of bacterial 16S ribosomal
Christine S. Chow +4 more
doaj +1 more source
Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression
Science Advances, 2018 Ribosomal RNA sequence variants are conserved, exhibit tissue-specific expression, and are found in actively translating ribosomes. The ribosome, the integration point for protein synthesis in the cell, is conventionally considered a homogeneous ...
Matthew M. Parks +10 more
semanticscholar +1 more source
Stochastic kinetics of ribosomes: single motor properties and collective behavior [PDF]
Physical Review E, vol.80, 011908 (2009), 2009 Synthesis of protein molecules in a cell are carried out by ribosomes. A ribosome can be regarded as a molecular motor which utilizes the input chemical energy to move on a messenger RNA (mRNA) track that also serves as a template for the polymerization of the corresponding protein.
arxiv +1 more source
Rapid determination of 16S ribosomal RNA sequences for phylogenetic analyses.
Proceedings of the National Academy of Sciences of the United States of America, 1985 Although the applicability of small subunit ribosomal RNA (16S rRNA) sequences for bacterial classification is now well accepted, the general use of these molecules has been hindered by the technical difficulty of obtaining their sequences. A protocol is
D. Lane +5 more
semanticscholar +1 more source
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Efficient depletion of ribosomal RNA for RNA sequencing in planarians
BMC Genomics, 2019 Background The astounding regenerative abilities of planarian flatworms prompt steadily growing interest in examining their molecular foundation. Planarian regeneration was found to require hundreds of genes and is hence a complex process.
Iana V. Kim +5 more
doaj +1 more source
Placeholder factors in ribosome biogenesis: please, pave my way
Microbial Cell, 2017 The synthesis of cytoplasmic eukaryotic ribosomes is an extraordinarily energy-demanding cellular activity that occurs progressively from the nucleolus to the cytoplasm.
Francisco J. Espinar-Marchena +2 more
doaj +1 more source
Nucleic Acids Research, 1989 Using a set of synthetic oligonucleotides homologous to broadly conserved sequences in-vitro amplification via the polymerase chain reaction followed by direct sequencing results in almost complete nucleotide determination of a gene coding for 16S ...
U. Edwards +4 more
semanticscholar +1 more source
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
Modeling of Ribosome Dynamics on a ds-mRNA under an External Load [PDF]
J. Chem. Phys. 145, 025101 (2016), 2016 Protein molecules in cells are synthesized by macromolecular machines called ribosomes. According to recent experimental data, we reduce the complexity of the ribosome and propose a model to express its activity in six main states. Using our model, we study the translation rate in different biological relevant situations in the presence of external ...
arxiv +1 more source