Results 61 to 70 of about 1,622,931 (284)

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Ribosomal transcription is regulated by PGC-1alpha and disturbed in Huntington’s disease

Scientific Reports, 2017
PGC-1α is a versatile inducer of mitochondrial biogenesis and responsive to the changing energy demands of the cell. As mitochondrial ATP production requires proteins that derive from translation products of cytosolic ribosomes, we asked whether PGC-1α ...
Sarah Jesse, Hanna Bayer, Marius C. Alupei, Martina Zügel, Medhanie Mulaw, Francesca Tuorto, Silke Malmsheimer, Karmveer Singh, Jürgen Steinacker, Uwe Schumann, Albert C. Ludolph, Karin Scharffetter-Kochanek, Anke Witting, Patrick Weydt, Sebastian Iben   +14 more
doaj   +1 more source

Adaptive remodeling of the bacterial proteome by specific ribosomal modification regulates Pseudomonas infection and niche colonisation [PDF]

, 2016
Post-transcriptional control of protein abundance is a highly important, underexplored regulatory process by which organisms respond to their environments.
A Brencic, A Rico, A Shevchenko, A Zhang, AJ Spiers, Alexandra M. Howat, BL Schneider, BR Borlee, BR Kulasekara, C Lamb, C Pesavento, C Reimmann, CD Boyd, Christopher S Hayes, CO Dimkpa, D Haas, D Yu, DC Naseby, DN Rodriguez-Navarro, E Barahona, E Barahona, E Burrowes, E Trampari, Eleftheria Trampari, F Harrison, G Desnoyers, G Mulley, G Zhao, Gerhard Saalbach, GL Winsor, H Kulasakara, I Kuiper, I Moll, J Boch, J Timmermans, JA Moscoso, JA Vizcaino, Jacob G. Malone, JG Malone, JH Miller, JT Greenberg, JW Hickman, K Kino, K Lapouge, K Maki, K Matsumoto, K Potrykus, KH Choi, KK Swinger, Lucia Grenga, M Christen, M Frederix, M Gao, M Jozefczak, M Lindeberg, M Starkey, MC Whalen, MH Rau, MV Nesterchuk, MW Silby, NM Wilf, P Sobrero, R Hengge, R Little, Richard H. Little, RP Ryan, S Heeb, S Lindenberg, Sebastian Pfeilmeier, SL Kuchma, T Afonyushkin, T Moller, T Morita, TS Walker, TT Hoang, TW Lynch, U Jenal, UA Bommer, VK Ramachandran, WC Winkler, WK Kang, WM Konyecsni, XF Xin, Y Irie   +83 more
core   +3 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Hepatitis C virus 3'UTR regulates viral translation through direct interactions with the host translation machinery. [PDF]

, 2013
The 3' untranslated region (3'UTR) of hepatitis C virus (HCV) messenger RNA stimulates viral translation by an undetermined mechanism. We identified a high affinity interaction, conserved among different HCV genotypes, between the HCV 3'UTR and the host ...
Bai, Yun, Doudna, Jennifer A, Zhou, Kaihong   +2 more
core   +2 more sources

2′-O-Methylation of Ribosomal RNA: Towards an Epitranscriptomic Control of Translation?

Biomolecules, 2018
Ribosomal RNA (rRNA) undergoes post-transcriptional modification of over 200 nucleotides, predominantly 2′-O-methylation (2′-O-Me). 2′-O-Methylation protects RNA from hydrolysis and modifies RNA strand flexibility but does not contribute to Watson-Crick ...
P. Monaco, V. Marcel, Jean-Jacques Diaz, Frédéric Catez   +3 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Genomic function during the lampbrush chromosome stage of amphibian oogenesis [PDF]

, 1966
Throughout its lengthy developmental history the disposition of the genetic material in the amphibian oocyte nucleus differs from that in other cell types.
Crippa, Marco, Davidson, Eric H., Kramer, Fred R., Mirsky, Alfred E.   +3 more
core   +1 more source

Methylation of Ribosomal RNA: A Mitochondrial Perspective

Frontiers in Genetics, 2020
Ribosomal RNA (rRNA) from all organisms undergoes post-transcriptional modifications that increase the diversity of its composition and activity. In mitochondria, specialized mitochondrial ribosomes (mitoribosomes) are responsible for the synthesis of 13
M. Isabel G. Lopez Sanchez, M. Isabel G. Lopez Sanchez, Miriam Cipullo, Miriam Cipullo, Shreekara Gopalakrishna, Shreekara Gopalakrishna, Anas Khawaja, Anas Khawaja, Joanna Rorbach, Joanna Rorbach   +9 more
doaj   +1 more source