Mining small RNA structure elements in untranslated regions of human and mouse mRNAs using structure-based alignment [PDF]
BMC Genomics, 2008 Background UnTranslated Regions (UTRs) of mRNAs contain regulatory elements for various aspects of mRNA metabolism, such as mRNA localization, translation, and mRNA stability.
Wen Dongrong +4 more
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Small interfering RNA targeted to stem-loop II of the 5' untranslated region effectively inhibits expression of six HCV genotypes [PDF]
Virology Journal, 2006 Background The antiviral action of interferon alpha targets the 5' untranslated region (UTR) used by hepatitis C virus (HCV) to translate protein by an internal ribosome entry site (IRES) mechanism.
Dash Srikanta +2 more
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Germline inherited small RNAs facilitate the clearance of untranslated maternal mRNAs in C. elegans embryos [PDF]
Nature Communications, 2021 Abstract Inheritance and clearance of maternal mRNAs are two of the most critical events required for animal early embryonic development. However, the mechanisms regulating this process are still largely unknown. Here, we show that together with maternal mRNAs, C.
Piergiuseppe Quarato +7 more
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Expression of the ISPpu9 transposase of Pseudomonas putida KT2440 is regulated by two small RNAs and the secondary structure of the mRNA 5′-untranslated region [PDF]
Nucleic Acids Research, 2021 Abstract Insertion sequences (ISs) are mobile genetic elements that only carry the information required for their own transposition. Pseudomonas putida KT2440, a model bacterium, has seven copies of an IS called ISPpu9 inserted into repetitive extragenic palindromic sequences. This work shows that the gene for ISPpu9 transposase, tnp, is
Guillermo Gómez-García +4 more
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Small Untranslated RNA Antitoxin inBacillus subtilis [PDF]
Journal of Bacteriology, 2005 ABSTRACTToxin-antitoxin (TA) modules are pairs of genes in which one member encodes a toxin that is neutralized or whose synthesis is prevented by the action of the product of the second gene, an antitoxin, which is either protein or RNA. We now report the identification of a TA module in the chromosome ofBacillus subtilisin which the antitoxin is an ...
Jessica M, Silvaggi +2 more
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Retraction Note: Small interfering RNA targeted to stem-loop II of the 5′ untranslated region effectively inhibits expression of six HCV genotypes [PDF]
Virology Journal, 2021 The antiviral action of interferon alpha targets the 5' untranslated region (UTR) used by hepatitis C virus (HCV) to translate protein by an internal ribosome entry site (IRES) mechanism. Although this sequence is highly conserved among different clinical strains, approximately half of chronically infected hepatitis C patients do not respond to ...
Ramesh Prabhu +2 more
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Characterization of the Small Untranslated RNA RyhB and Its Regulon inVibrio cholerae [PDF]
Journal of Bacteriology, 2005 ABSTRACTNumerous small untranslated RNAs (sRNAs) have been identified inEscherichia coliin recent years, and their roles are gradually being defined. However, few of these sRNAs appear to be conserved inVibrio cholerae, and both identification and characterization of sRNAs inV. choleraeremain at a preliminary stage. We have characterized one of the few
Brigid M, Davis +4 more
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Migration of Small Ribosomal Subunits on the 5′ Untranslated Regions of Capped Messenger RNA [PDF]
International Journal of Molecular Sciences, 2019 Several control mechanisms of eukaryotic gene expression target the initiation step of mRNA translation. The canonical translation initiation pathway begins with cap-dependent attachment of the small ribosomal subunit (SSU) to the messenger ribonucleic acid (mRNA) followed by an energy-dependent, sequential ‘scanning’ of the 5′ untranslated regions ...
Nikolay E. Shirokikh +4 more
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Satellite RNA-Derived Small Interfering RNA satsiR-12 Targeting the 3′ Untranslated Region of Cucumber Mosaic Virus Triggers Viral RNAs for Degradation [PDF]
Journal of Virology, 2011 ABSTRACT RNA silencing provides protection against RNA viruses by targeting both the helper virus and its satellite RNA (satRNA). Virus-derived small interfering RNAs (vsiRNAs) bound with Argonaute (AGO) proteins are presumed participants in the silencing process.
Hui, Zhu +6 more
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Inhibition of hepatitis C virus IRES-mediated translation by small RNAs analogous to stem-loop structures of the 5'-untranslated region [PDF]
Nucleic Acids Research, 2004 Translation of the hepatitis C virus (HCV) RNA is mediated by the interaction of ribosomes and cellular proteins with an internal ribosome entry site (IRES) located within the 5'-untranslated region (5'-UTR). We have investigated whether small RNA molecules corresponding to the different stem-loop (SL) domains of the HCV IRES, when introduced in trans,
Ray, Partho Sarothi, Das, Saumitra
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