Results 1 to 10 of about 4,587,295 (307)
Smuggling on the Nanoscale—Fusogenic Liposomes Enable Efficient RNA-Transfer with Negligible Immune Response In Vitro and In Vivo [PDF]
Pharmaceutics, 2023 The efficient and biocompatible transfer of nucleic acids into mammalian cells for research applications or medical purposes is a long-standing, challenging task.
Marco Hoffmann +13 more
doaj +2 more sources
Transfer RNA-derived small RNA: an emerging small non-coding RNA with key roles in cancer
Experimental Hematology & Oncology, 2022 Transfer RNAs (tRNAs) promote protein translation by binding to the corresponding amino acids and transporting them to the ribosome, which is essential in protein translation.
Xinliang Gu +5 more
doaj +1 more source
tRNAscan-SE 2.0: improved detection and functional classification of transfer RNA genes
bioRxiv, 2019 tRNAscan-SE has been widely used for transfer RNA (tRNA) gene prediction for over twenty years, developed just as the first genomes were decoded. With the massive increase in quantity and phylogenetic diversity of genomes, the accurate detection and ...
Patricia P. Chan +3 more
semanticscholar +1 more source
Human transfer RNA modopathies: diseases caused by aberrations in transfer RNA modifications
The FEBS Journal, 2020 tRNA molecules are post‐transcriptionally modified by tRNA modification enzymes. Although composed of different chemistries, more than 40 types of human tRNA modifications play pivotal roles in protein synthesis by regulating tRNA structure and stability
T. Chujo, K. Tomizawa
semanticscholar +1 more source
Molecular Therapy, 2014 Vector systems based on different retroviruses are widely used to achieve stable integration and expression of transgenes. More recently, transient genetic manipulation systems were developed that are based on integration- or reverse transcription ...
Martin V. Hamann +8 more
semanticscholar +1 more source
ER Membrane Contact Sites: Key Platforms for Biogenesis of RNA-Containing Extracellular Vesicles
Contact, 2022 The mechanisms by which cytoplasmic cargoes such as RNAs are incorporated into extracellular vesicles (EVs) are poorly understood. In a recent article published in Developmental Cell, we describe a novel function of endoplasmic reticulum membrane contact
Bahnisikha Barman +2 more
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Highly Sensitive Northern Hybridization Using a Rapid Protocol for Downward Alkaline Blotting of RNA
BioTechniques, 1998 A simple and fast RNA gel blot procedureis described that uses 50 mM NaOH tosimultaneously transfer and fix RNA to apositively charged nylon membrane. TheRNA is transferred in a downward direction,and transfer is routinely completedwithin 2.5 h.
Ivan L. Ingelbrecht +2 more
doaj +1 more source
Mitochondrial DNA. Part B. Resources, 2021 The complete mitogenome sequence of Sinogastromyzon szechuanensis was obtained using next generation sequencing and confirmed via overlap-PCR method.
Wei Li +7 more
doaj +1 more source
Characterization of UVA-Induced Alterations to Transfer RNA Sequences
Biomolecules, 2020 Ultraviolet radiation (UVR) adversely affects the integrity of DNA, RNA, and their nucleoside modifications. By employing liquid chromatography–tandem mass spectrometry (LC–MS/MS)-based RNA modification mapping approaches, we identified the transfer RNA (
Congliang Sun +2 more
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Transfer RNA-derived small RNAs in tumor microenvironment
Molecular Cancer, 2023 Transfer RNAs (tRNAs) are a class of non-coding RNAs responsible for amino acid translocation during protein synthesis and are ubiquitously found in organisms.
Mei Yang +5 more
doaj +1 more source