Results 1 to 10 of about 920,709 (301)

Structural signatures of thermal adaptation of bacterial ribosomal RNA, transfer RNA, and messenger RNA. [PDF]

PLoS ONE, 2017
Temperature adaptation of bacterial RNAs is a subject of both fundamental and practical interest because it will allow a better understanding of molecular mechanism of RNA folding with potential industrial application of functional thermophilic or ...
Clara Jegousse, Yuedong Yang, Jian Zhan, Jihua Wang, Yaoqi Zhou   +4 more
doaj   +2 more sources

Smuggling on the Nanoscale—Fusogenic Liposomes Enable Efficient RNA-Transfer with Negligible Immune Response In Vitro and In Vivo [PDF]

Pharmaceutics, 2023
The efficient and biocompatible transfer of nucleic acids into mammalian cells for research applications or medical purposes is a long-standing, challenging task.
Marco Hoffmann, Sven Gerlach, Masanari Takamiya, Samar Tarazi, Nils Hersch, Agnes Csiszár, Ronald Springer, Georg Dreissen, Hanno Scharr, Sepand Rastegar, Tanja Beil, Uwe Strähle, Rudolf Merkel, Bernd Hoffmann   +13 more
doaj   +2 more sources

Crystal structures and snapshots along Tpt1-catalyzed phosphate transfer from nucleic acid to NAD+ [PDF]

Nature Communications
Tpt1/TRPT1/KptA family proteins are evolutionarily conserved in all three domains of life. In fungi and plants, Tpt1 transfers 2’-PO4 2- from tRNA splice junction to NAD+, which is the final step of tRNA maturation and is critical for the function of ...
Chulei Cao, Jie Yang, Weizhen Zhang, Jiaqin Chen, Yanqing Gao, Yuqi Yao, Yixi Zhang, Huili Li, Linxi Li, Zhaorong Luo, Chenxi Wang, Guangli Tang, Ruixue Cui, Hehua Liu, Qiyao Wang, Zhen Huang, Jinbiao Ma, Jianhua Gan   +17 more
doaj   +2 more sources

PltRNAdb: Plant transfer RNA database.

PLoS ONE, 2022
Transfer RNAs (tRNAs) are intermediate-sized non-coding RNAs found in all organisms that help translate messenger RNA into protein. Recently, the number of sequenced plant genomes has increased dramatically.
Morad M Mokhtar, Achraf El Allali
doaj   +3 more sources

Global analysis of contact-dependent human-to-mouse intercellular mRNA and lncRNA transfer in cell culture

eLife, 2023
Full-length mRNAs transfer between adjacent mammalian cells via direct cell-to-cell connections called tunneling nanotubes (TNTs). However, the extent of mRNA transfer at the transcriptome-wide level (the ‘transferome’) is unknown.
Sandipan Dasgupta, Daniella Y Dayagi, Gal Haimovich, Emanuel Wyler, Tsviya Olender, Robert H Singer, Markus Landthaler, Jeffrey E Gerst   +7 more
doaj   +1 more source

Exogenous RNA as a Regulatory Signal during a Plant’s Interaction with the Biotic Environment: An Evolutionary Perspective and Future Applications in Agriculture

Plants, 2021
Environmental RNAi (eRNAi) is a sequence-specific regulation of endogenous gene expression in a responsive organism by exogenous RNA. While exogenous RNA transfer between organisms of different kingdoms of life have been unambiguously identified in ...
Sergey Ivashuta, Alberto Iandolino, Greg Watson   +2 more
doaj   +1 more source

Myosin-Va-dependent cell-to-cell transfer of RNA from Schwann cells to axons. [PDF]

PLoS ONE, 2013
To better understand the role of protein synthesis in axons, we have identified the source of a portion of axonal RNA. We show that proximal segments of transected sciatic nerves accumulate newly-synthesized RNA in axons.
José R Sotelo, Lucía Canclini, Alejandra Kun, José R Sotelo-Silveira, Lei Xu, Horst Wallrabe, Aldo Calliari, Gonzalo Rosso, Karina Cal, John A Mercer   +9 more
doaj   +1 more source

Thinking Quantitatively of RNA-Based Information Transfer via Extracellular Vesicles: Lessons to Learn for the Design of RNA-Loaded EVs

Pharmaceutics, 2021
Extracellular vesicles (EVs) are 50–1000 nm vesicles secreted by virtually any cell type in the body. They are expected to transfer information from one cell or tissue to another in a short- or long-distance way. RNA-based transfer of information via EVs
Max Piffoux, Jeanne Volatron, Amanda K. A. Silva, Florence Gazeau   +3 more
doaj   +1 more source

A novel mistranslating tRNA model in Drosophila melanogaster has diverse, sexually dimorphic effects

G3: Genes, Genomes, Genetics, 2022
Transfer RNAs (tRNAs) are the adaptor molecules required for reading the genetic code and producing proteins. Transfer RNA variants can lead to genome-wide mistranslation, the misincorporation of amino acids not specified by the standard genetic code ...
Joshua R Isaacson, Matthew D Berg, Brendan Charles, Jessica Jagiello, Judit Villén, Christopher J Brandl, Amanda J Moehring   +6 more
doaj   +1 more source

Tissue-specific differences in human transfer RNA expression. [PDF]

PLoS Genetics, 2006
Over 450 transfer RNA (tRNA) genes have been annotated in the human genome. Reliable quantitation of tRNA levels in human samples using microarray methods presents a technical challenge.
Kimberly A Dittmar, Jeffrey M Goodenbour, Tao Pan   +2 more
doaj   +1 more source