Results 1 to 10 of about 4,885,831 (366)
Comparative analysis of RNA families reveals distinct repertoires for each domain of life. [PDF]
PLoS Computational Biology, 2012 The RNA world hypothesis, that RNA genomes and catalysts preceded DNA genomes and genetically-encoded protein catalysts, has been central to models for the early evolution of life on Earth.
Marc P Hoeppner +2 more
doaj +9 more sources
Transfer RNA and Origins of RNA Interference [PDF]
Frontiers in Molecular Biosciences, 2021 Almost 30 years ago the first microRNA (miRNA) was detected (Lee et al., 1993), later put in mechanistical context by the discovery of the RNA interference (RNAi) and RNA-induced silencing complex (RISC). miRNA is the variable RISC element (guide) that recognizes messenger RNA (mRNA) targets in the RNAi process facilitated by Argonaute (Ago) proteins ...
Andrey Grigoriev
doaj +5 more sources
A novel mistranslating tRNA model in Drosophila melanogaster has diverse, sexually dimorphic effects [PDF]
G3: Genes, Genomes, Genetics, 2022 Transfer RNAs (tRNAs) are the adaptor molecules required for reading the genetic code and producing proteins. Transfer RNA variants can lead to genome-wide mistranslation, the misincorporation of amino acids not specified by the standard genetic code ...
Joshua R Isaacson +6 more
doaj +3 more sources
Nature Communications, 2020 Extracellular vesicles (EV) facilitate intercellular transfer of biological material including RNA, but the regulatory mechanisms for their formation and transfer are incompletely known.
Olivier G. de Jong +13 more
doaj +2 more sources
Transfer RNA and human disease [PDF]
Frontiers in Genetics, 2014 Pathological mutations in tRNA genes and tRNA processing enzymes are numerous and result in very complicated clinical phenotypes. Mitochondrial tRNA (mt-tRNA) genes are hotspots for pathological mutations and over 200 mt-tRNA mutations have been linked ...
Jamie A Abbott +2 more
doaj +3 more sources
Transfer RNA-derived small RNAs in the cancer transcriptome [PDF]
Pflügers Archiv: European Journal of Physiology, 2016 The cellular lifetime includes stages such as differentiation, proliferation, division, senescence and apoptosis.These stages are driven by a strictly ordered process of transcription dynamics.
A Dueck +38 more
core +2 more sources
Prebiotic chiral transfer from self-aminoacylating ribozymes may favor either handedness [PDF]
Nature CommunicationsModern life is essentially homochiral, containing D-sugars in nucleic acid backbones and L-amino acids in proteins. Since coded proteins are theorized to have developed from a prebiotic RNA World, the homochirality of L-amino acids observed in all known ...
Josh Kenchel +10 more
doaj +2 more sources
Transfer RNA Comes of Age [PDF]
RNA, 2015 The year the journal RNA was founded was slated by some in scientific publishing to be the year that one particular type of RNA\u27s run in the spotlight would end.
Ibba, Michael
core +7 more sources
Nature Communications, 2019 The limited availability of high-resolution 3D RNA structures for model training limits RNA secondary structure prediction. Here, the authors overcome this challenge by pre-training a DNN on a large set of predicted RNA structures and using transfer ...
Jaswinder Singh +3 more
doaj +2 more sources
Small RNA-based feedforward loop with AND-gate logic regulates extrachromosomal DNA transfer in Salmonella [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2015 Horizontal gene transfer via plasmid conjugation is a major driving force in microbial evolution but constitutes a complex process that requires synchronization with the physiological state of the host bacteria.
Casadesús Pursals, Josep +3 more
core +2 more sources