Results 1 to 10 of about 4,659,890 (256)

Platelets and tumor-associated RNA transfer.

Blood, 2021
Until recently the nucleic acid content of platelets was considered to be fully determined by their progenitor megakaryocyte. However, it is now well understood that additional mediators (e.g.
D'Ambrosi S, Nilsson RJ, Wurdinger T.
europepmc   +2 more sources

Schwann cell-like differentiated adipose stem cells promote neurite outgrowth via secreted exosomes and RNA transfer. [PDF]

Stem Cell Res Ther, 2018
Adipose derived stem cells can be stimulated to produce a growth factor rich secretome which enhances axon regeneration. In this study we investigated the importance of exosomes, extracellular vesicles released by many different cell types, including ...
Ching RC, Wiberg M, Kingham PJ.
europepmc   +2 more sources

Structural signatures of thermal adaptation of bacterial ribosomal RNA, transfer RNA, and messenger RNA. [PDF]

PLoS ONE, 2017
Temperature adaptation of bacterial RNAs is a subject of both fundamental and practical interest because it will allow a better understanding of molecular mechanism of RNA folding with potential industrial application of functional thermophilic or ...
Clara Jegousse, Yuedong Yang, Jian Zhan, Jihua Wang, Yaoqi Zhou   +4 more
doaj   +2 more sources

Smuggling on the Nanoscale—Fusogenic Liposomes Enable Efficient RNA-Transfer with Negligible Immune Response In Vitro and In Vivo [PDF]

Pharmaceutics, 2023
The efficient and biocompatible transfer of nucleic acids into mammalian cells for research applications or medical purposes is a long-standing, challenging task.
Marco Hoffmann, Sven Gerlach, Masanari Takamiya, Samar Tarazi, Nils Hersch, Agnes Csiszár, Ronald Springer, Georg Dreissen, Hanno Scharr, Sepand Rastegar, Tanja Beil, Uwe Strähle, Rudolf Merkel, Bernd Hoffmann   +13 more
doaj   +2 more sources

A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA

Nature Communications, 2020
Extracellular vesicles (EV) facilitate intercellular transfer of biological material including RNA, but the regulatory mechanisms for their formation and transfer are incompletely known.
Olivier G. de Jong, Daniel E. Murphy, Imre Mäger, Eduard Willms, Antonio Garcia-Guerra, Jerney J. Gitz-Francois, Juliet Lefferts, Dhanu Gupta, Sander C. Steenbeek, Jacco van Rheenen, Samir El Andaloussi, Raymond M. Schiffelers, Matthew J. A. Wood, Pieter Vader   +13 more
doaj   +2 more sources

The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer. [PDF]

Cell, 2018
Pastuzyn ED, Day CE, Kearns RB, Kyrke-Smith M, Taibi AV, McCormick J, Yoder N, Belnap DM, Erlendsson S, Morado DR, Briggs JAG, Feschotte C, Shepherd JD.   +12 more
europepmc   +3 more sources

RNA secondary structure prediction using an ensemble of two-dimensional deep neural networks and transfer learning

Nature Communications, 2019
The limited availability of high-resolution 3D RNA structures for model training limits RNA secondary structure prediction. Here, the authors overcome this challenge by pre-training a DNN on a large set of predicted RNA structures and using transfer ...
Jaswinder Singh, Jack Hanson, Kuldip Paliwal, Yaoqi Zhou   +3 more
doaj   +2 more sources

Trans-kingdom small RNA transfer during host-pathogen interactions: The case of P. falciparum and erythrocytes. [PDF]

RNA Biol, 2017
Walzer KA, Chi JT.
europepmc   +2 more sources

Mechanisms of Transfer RNA Fragments Functionality Within and Between Cells and Organisms [PDF]

Cells
Transfer RNA-derived fragments (tRFs) have become a significant category of small non-coding RNAs that likely play vital roles in various cellular functions.
Sathyanarayanan Vaidhyanathan, Yan X. Lin, Adesupo A. Adetowubo, Fatmanur Kiliç, Sai Anusha Jonnalagadda, Andrey Grigoriev   +5 more
doaj   +2 more sources

New paradigms in thrombosis: novel mediators and biomarkers platelet RNA transfer. [PDF]

J Thromb Thrombolysis, 2014
Clancy L, Freedman JE.
europepmc   +2 more sources