Results 61 to 70 of about 559,369 (259)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Complete mitochondrial genome of the coconut black-headed caterpillar Opisina arenosella (Lepidoptera: Gelechioidea: Xyloryctidae)

Mitochondrial DNA. Part B. Resources, 2019
In the present study, we determined the complete mitogenome of Opisina arenosella, the first for the family Xyloryctidae. This mitochondrial genome contains 15,389 bp, with an A + T content of 80.5% and consists of 13 protein-coding genes, 22 transfer ...
Rui Meng, Yao He, Su Ao, Bo Cai
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

RNA secondary structure prediction using an ensemble of two-dimensional deep neural networks and transfer learning

Nature Communications, 2019
The limited availability of high-resolution 3D RNA structures for model training limits RNA secondary structure prediction. Here, the authors overcome this challenge by pre-training a DNN on a large set of predicted RNA structures and using transfer ...
Jaswinder Singh, Jack Hanson, Kuldip Paliwal, Yaoqi Zhou   +3 more
doaj   +1 more source

THE STRUCTURES AND FUNCTIONS OF TRANSFER RNA

Progress in Biophysics and Molecular Biology, 1978
Publisher Summary Transfer ribonucleic acid (tRNA) is the term used to describe a group of low molecular weight RNA molecules that play a vital part in protein synthesis Transfer RNAs were assigned the role of adaptor molecules by Hoagland et al.
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Extracellular RNA transfer from non-malignant human cholangiocytes can promote cholangiocarcinoma growth. [PDF]

FEBS Open Bio, 2021
Ota Y, Takahashi K, Otake S, Tamaki Y, Okada M, Yan I, Aso K, Fujii S, Patel T, Haneda M.   +9 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Complete chloroplast genome sequence of Chrysosplenium macrophyllum and Chrysosplenium flagelliferum (Saxifragaceae)

Mitochondrial DNA. Part B. Resources, 2020
The complete chloroplast genome of Chrysosplenium macrophyllum Oliv. and Chrysosplenium flagelliferum Fr. Schmidt. were reported in this study. The chloroplast genomes were 152,837 bp for C. macrophyllum and 151,679 bp for C. flagelliferum.
Wen-Jie Yan, Tian-Ge Yang, Rui Liao, Zhi-Hua Wu, Rui Qin, Hong Liu   +5 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source