Results 61 to 70 of about 925,090 (301)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

RNA compaction and iterative scanning for small RNA targets by the Hfq chaperone

Nature Communications
RNA-guided enzymes must quickly search a vast sequence space for their targets. This search is aided by chaperones such as Hfq, a protein that mediates regulation by bacterial small RNAs (sRNAs).
Ewelina M. Małecka, Sarah A. Woodson
doaj   +1 more source

SPIN-LABELED TRANSFER RNA [PDF]

Proceedings of the National Academy of Sciences, 1969
The α-amino group of valyl-tRNA has been combined chemically with a nitroxide spin label through an amide linkage. This spin-labeled aminoacyl-tRNA has an electron paramagnetic resonance spectrum which reflects the mobility of the aminoacyl end of the tRNA molecule.
B M, Hoffman, P, Schofield, A, Rich
openaire   +2 more sources

GIVE: portable genome browsers for personal websites. [PDF]

, 2018
Growing popularity and diversity of genomic data demand portable and versatile genome browsers. Here, we present an open source programming library called GIVE that facilitates the creation of personalized genome browsers without requiring a system ...
Alvin Zheng, B Sridhar, B Sridhar, C Tyner, D Barrios, D Comer, E Lieberman-Aiden, E Sharma, F Ozsolak, F Yue, FH Biase, JD Buenrostro, JG Aw, JT Robinson, LD Stein, ME Skinner, MJ Fullwood, Qiuyang Wu, R Bayer, R Li, R Mourad, S Carrere, Sheng Zhong, TC Nguyen, The ENCODE Project Consortium, VW Zhou, WJ Kent, X Li, X Zhou, Xiaoyi Cao, Z Lu, Zhangming Yan   +31 more
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Mapping Current Studies of tRNA Fragments onto Disease Landscape

Biomolecules
Transfer-RNA-derived fragments (tRFs) are a relatively recently discovered class of non-coding RNAs derived from both precursor and mature transfer RNAs (tRNAs).
Sathyanarayanan Vaidhyanathan, MacKenna Durbin, Adesupo A. Adetowubo, Lisa H. Do, Sheida Kavehmoghaddam, Sai Anusha Jonnalagadda, Bryan Ramirez Aguilar, Tamin Ortiz-Gomez, Yan X. Lin, Asim Dave, Fatmanur Kiliç, Alexa R. Karp, Mohammed Imthiyas Rahmah, Noor F. Riaz, Nikhila Mandava, Aleece Siner, Andrey Grigoriev   +16 more
doaj   +1 more source

The complete plastid genome of a marine microalgae Cryptophyceae sp. CCMP2293 (Cryptophyta)

Mitochondrial DNA. Part B. Resources, 2019
In this study, we present the complete plastid genome of Cryptophyceae sp. CCMP2293. The circular genome is 139,208 bp in length and contains 142 protein-coding genes (PCGs), 30 transfer RNA (tRNA) genes, 6 ribosome RNA (rRNA) genes, and 1 transfer ...
Kuipeng Xu, Shunxin Hu, Xianghai Tang
doaj   +1 more source

The kinetic mechanism of bacterial ribosome recycling. [PDF]

, 2017
Bacterial ribosome recycling requires breakdown of the post-termination complex (PoTC), comprising a messenger RNA (mRNA) and an uncharged transfer RNA (tRNA) cognate to the terminal mRNA codon bound to the 70S ribosome.
Chen, Yuanwei, Cooperman, Barry S., Kaji, Akira, Kaji, Hideko   +3 more
core   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Bifunctional transfer-messenger RNA [PDF]

Biochimie, 2011
Transfer-messenger RNA (tmRNA) is a bifunctional RNA that has properties of a tRNA and an mRNA. tmRNA uses these two functions to release ribosomes stalled during translation and target the nascent polypeptides for degradation. This concerted reaction, known as trans-translation, contributes to translational quality control and regulation of gene ...
Kenneth C, Keiler, Nitya S, Ramadoss
openaire   +2 more sources