Results 71 to 80 of about 924,039 (259)

The first mitochondrial genome for the subfamily Asopinae (Heteroptera: Pentatomidae) and its phylogenetic implications

Mitochondrial DNA. Part B. Resources, 2017
Here, we determined the complete mitogenome of Picromerus griseus, the first for the subfamily Asopinae. This mitochondrial genome contains 16,338 bp, with an A + T content of 71.69%, and contains 37 typical mitochondrial genes (13 protein-coding genes ...
Qing Zhao, Jiufeng Wei, Wanqing Zhao, Bo Cai, Xin Du, Hufang Zhang   +5 more
doaj   +1 more source

Analysis of Mitochondrial Transfer RNA Mutations in Breast Cancer

Balkan Journal of Medical Genetics, 2022
Damage of mitochondrial functions caused by mitochondrial DNA (mtDNA) pathogenic mutations had long been proposed to be involved in breast carcinogenesis. However, the detailed pathological mechanism remained deeply undetermined.
Ding H.J., Zhao Y.P., Jiang Z.C., Zhou D.T., Zhu R.   +4 more
doaj   +1 more source

A mutate-and-map protocol for inferring base pairs in structured RNA

, 2013
Chemical mapping is a widespread technique for structural analysis of nucleic acids in which a molecule's reactivity to different probes is quantified at single-nucleotide resolution and used to constrain structural modeling.
CS Chow, D Moazed, DH Mathews, EE Regulski, JB Lucks, JG Underwood, JP Staley, KA Wilkinson, M Kertesz, M Mandal, N Kulshina, NB Leontis, P Cordero, P Cordero, P Rocca-Serra, P Tijerina, PJ Lukavsky, R Rydzanicz, RC Spitale, RF Gesteland, S Mitra, S Washietl, S Yoon, SA Mortimer, SE Wells, SM Vasa, SW Brostoff, VD Sood, W Kladwang, W Kladwang, W Kladwang, W Kladwang, Y Rhee   +32 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Transfer RNA and Origins of RNA Interference

Frontiers in Molecular Biosciences, 2021
Andrey Grigoriev
doaj   +1 more source

Complete chloroplast genome sequence of Chrysosplenium ramosum and Chrysosplenium alternifolium (Saxifragaceae)

Mitochondrial DNA. Part B. Resources, 2020
The complete chloroplast genome of Chrysosplenium ramosum Maxim. and Chrysosplenium alternifolium L. were reported in this study. The chloroplast genomes were 153,460 bp for C. ramosum and 152,619 bp for C. alternifolium.
Wen-jie Yan, Hong Liu, Tian-ge Yang, Rui Liao, Rui Qin   +4 more
doaj   +1 more source

Idiosyncratic evolution of conserved eukaryote proteins that are similar in sequence to archaeal or bacterial proteins [PDF]

, 2008
Sequence comparisons have been made between the proteins of 571 prokaryote species including 46 archaea and 525 bacteria and the set of human proteins.
Roy J. Britten
core   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Identification of novel clostridium perfringens type E strains that carry an iota toxin plasmid with a functional enterotoxin gene [PDF]

, 2011
Clostridium perfringens enterotoxin (CPE) is a major virulence factor for human gastrointestinal diseases, such as food poisoning and antibiotic associated diarrhea. The CPE-encoding gene (cpe) can be chromosomal or plasmid-borne.
A Deguchi, A Gurjar, A Heikinheimo, BA McClane, Bruce A. McClane, D Lepp, Herman Tse, HS Garmony, J Li, J Li, J Li, J Li, J Li, JA Parsons, Jihong Li, K Miyamoto, K Miyamoto, K Miyamoto, K Miyamoto, Kanako Mimura, Kazuaki Miyamoto, KH Harry, Masahiro Nagahama, MR Sarker, Natsuko Yumine, S Sayeed, S Sayeed, Shigeru Akimoto, SJ Billington, SR Mueller-Spits, T Hirokawa, Y Miki, Y Zhao   +32 more
core   +5 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source