Results 111 to 120 of about 218,333 (309)

Metabolite-dependent regulation of gene expression in trypanosoma brucei [PDF]

, 2013
Mechanisms regulating gene expression in trypanosomatid protozoa differ significantly from those in other eukaryotes. Transcription of the genome appears to be more or less constitutive with the polyadenylation and trans-splicing of large polycistronic ...
Archer, Batey, Besteiro, Birkholtz, Breaker, Carter, Clayton, Coustou, De Gaudenzi, Ebikeme, Fairlamb, Hendriks, Jacob, Jensen, Kabani, Lamour, Mangold, Martinez-Calvillo, Nguyen, Perez-Leal, Persson, Phillips, Stuart, Veitch, Vincent, Ward, Willert, Willert, Willert, Wirtz, Wurst, Wurst, Xiao, Xiao, Zhang   +34 more
core   +1 more source

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

Advanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang, Hui Geng, Zhengyan Yao, Yuan Jiang, Can Chen, Zequn Lu, Shuangshuang Tian, Ming Zhang, Ruiyan Liu, Chenxi Feng, Bin Li, Xiaoping Miao, Jianbo Tian, Shaokai Zhang, Ying Zhu   +14 more
wiley   +1 more source

RNA binding proteins (RBPs) on genetic stability and diseases

Global Medical Genetics
RNA-binding proteins (RBPs) are integral components of cellular machinery, playing crucial roles in the regulation of gene expression and maintaining genetic stability. Their interactions with RNA molecules govern critical processes such as mRNA splicing,
Abdullahi Tunde Aborode, Ohilebo Abdulateef Abass, Shaibu Nasiru, Mary Ugunnushe Eigbobo, Sumana Nefishatu, Abdullahi Idowu, Zainab Tiamiyu, Aeshah A. Awaji, Nike Idowu, Babawale Roqeeb Busayo, Qasim Mehmood, Isreal Ayobami Onifade, Sodiq Fakorede, Ashraf Akintayo Akintola   +13 more
doaj   +1 more source

Intracellular interferons in fish : a unique means to combat viral infection [PDF]

, 2013
Peer reviewedPublisher ...
A Lopez-Munoz, A Matsuo, A Pindel, AJ Sadler, B Sun, Bei Huang, Bertrand Collet, C Stein, Chris J. Secombes, CM Ahmed, D Aggad, E Kalie, EL Ooi, F Sun, FF Yu, J Zou, J Zou, J Zou, J Zou, JM Gonzalez-Navajas, Jun Zou, Karen L. Mossman, KE Taylor, M Chang, M Shin-Ya, Ming-Xian Chang, MK Purcell, N Sathish, O Haller, OJ Hamming, PE Phelan, Pin Nie, S Biacchesi, S Campbell, S Long, S Long, SA Martin, SV Kotenko, SY Liu, T Svingerud, V Bergan, Y Palti, YB Zhang, Z Li, Z Qi, Zhanglong Yu   +45 more
core   +3 more sources

Tumor suppression by RNA from the 3′ untranslated region of α-tropomyosin

Cell, 1993
NMU2, a nondifferentiating mutant myogenic cell line, gives rise to rhabdomyosarcomas in mice. We show that constitutive expression of RNA from 0.2 kb of the alpha-tropomyosin (Tm) 3' untranslated region (UTR), but not control 3'UTRs, suppresses anchorage-independent growth and tumor formation by NMU2 cells.
F, Rastinejad, M J, Conboy, T A, Rando, H M, Blau   +3 more
openaire   +2 more sources

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Tissue-specific expression of high-voltage-activated dihydropyridine-sensitive L-type calcium channels [PDF]

, 1991
The cloning of the cDNA for the α1 subunit of L-type calcium channels revealed that at least two genes (CaCh1 and CaCh2) exist which give rise to several splice variants.
Caffrey J. M., Catterall W. A., Ellis S. B., Glossmann H., Grabner M., Hofmann F., Hoshi T., Jay S. D., Jongh K. S., Kim H. S., Koch W. J., Koch W. J., Melton D. A., Olson E. N., Perez-Reyes E., Rampe D. E., Reuter H., Ruth P., Ruth P., Sambrook J., Sanger F., Schubert D., Shih H.-T., Snutch T. P., Tanabe T., Thomas P. S., Tsien R. W.   +26 more
core   +2 more sources

A phylogenetically conserved sequence within viral 3' untranslated RNA pseudoknots regulates translation.

Molecular and Cellular Biology, 1993
Both the 68-base 5' leader (omega) and the 205-base 3' untranslated region (UTR) of tobacco mosaic virus (TMV) promote efficient translation. A 35-base region within omega is necessary and sufficient for the regulation. Within the 3' UTR, a 52-base region, composed of two RNA pseudoknots, is required for regulation.
V, Leathers, R, Tanguay, M, Kobayashi, D R, Gallie   +3 more
openaire   +3 more sources

The Transcription Factor FgSge1 Harnesses the SAGA Complex to Activate Mycotoxin Biosynthesis and Fungal Virulence

Advanced Science, EarlyView.
This study reveals the molecular mechanism by which the transcription factor FgSge1 regulates mycotoxin biosynthesis and virulence in Fusarium graminearum. FgSge1 binds to the TAARGTTT cis‐element, enabling self‐activation. It recruits the SAGA complex, promotes histone acetylation, and facilitates jet‐like chromatin remodeling, thereby activating ...
Yueqi Zhang, Jingrui Wang, Qiaowan Chen, Chen Jiao, Yun Chen, Zhongshou Wu, Zhonghua Ma   +6 more
wiley   +1 more source

ANALISIS MOLEKULER GENOM VIRUS HEPATITIS C SERTA PERANANNYA DALAM PATOGENESIS INFEKSI

JKS (Jurnal Kedokteran Syiah Kuala), 2012
Abstrak. Virus Hepatitis C (HCV) adalah penyebab Hepatitis C, suatu penyakit yang masih menjadi masalah kesehatan di dunia, khususnya di Indonesia. Virus ini bergenom RNA untai tunggal yang berukuran sekitar 9,6 kilobasa.
Tristia Rinanda
doaj