Antagonistic and cooperative AGO2-PUM interactions in regulating mRNAs. [PDF]
, 2018 Approximately 1500 RNA-binding proteins (RBPs) profoundly impact mammalian cellular function by controlling distinct sets of transcripts, often using sequence-specific binding to 3' untranslated regions (UTRs) to regulate mRNA stability and translation ...
Estep, Jason A +4 more
core +3 more sources
“More” Artificial mRNAs: Beyond the Art of Nature
Advanced Science, EarlyView.Inspired by nature yet transcending it, synthetic mRNA is being redesigned beyond the canonical architecture. This review highlights emerging forms—circular, branched, and self‐amplifying mRNAs—that expand stability, persistence, and functional control, illustrating how artificial mRNA is evolving into a new medium for programmable biological ...
Yuanzhe Cui +3 more
wiley +1 more source
Advanced Science, EarlyView.The RNA G‐quadruplexes formed at the 5'‐end of the RNA component of human telomerase possess extreme slow unfolding rate, rendering them resistant to nuclease degradation. The helicase DHX36 overcame this kinetic barrier and significantly reduced the folded fraction.
Qun Luo +5 more
wiley +1 more source
Integrative analysis of quantitative trait loci of alternative polyadenylation and GWAS highlights key regulators of milk production and immune traits in Holstein. [PDF]
Anim GenetAbstract Understanding the genetic regulation of complex traits like mastitis in Holstein dairy cows remains a challenge, despite significant advancements in breeding techniques. This study integrates 3′‐untranslated region alternative polyadenylation (APA) quantitative trait loci (3′aQTL) mapping with genome‐wide association studies (GWASs) to ...
Tao X +6 more
europepmc +2 more sources
Introduction and Expression of a Rabbit β-globin Gene in Mouse Fibroblasts [PDF]
, 1979 The cloned chromosomal rabbit ß-globin gene has been introduced into mouse fibroblasts by DNA-mediated gene transfer (transformation). In this report, we examine the expression of the rabbit gene in six independent transformants that contain from 1 to 20
Axel, R. +5 more
core
Human fibroblast interferon RNA transcripts of different sizes in poly(I).poly(C) induced cells [PDF]
, 1983 A
Content, Jean +3 more
core +2 more sources
Additive and Partially Dominant Effects from Genomic Variation Contribute to Rice Heterosis
Advanced Science, EarlyView.Additive and partially dominant effects, namely at mid‐parent levels or values between mid‐parent and parental levels, respectively, are the predominant inheritance patterns of heterosis‐associated molecules. These two genetic effects contribute to heterosis of agronomic traits in both rice and maize, as well as biomass heterosis in Arabidopsis ...
Zhiwu Dan +8 more
wiley +1 more source
Properties of untranslated regions of the
BMC Genomics, 2009 Background During evolution selection forces such as changing environments shape the architecture of genomes. The distribution of genes along chromosomes and the length of intragenic regions are basic genomic features known to play a major role in the ...
Tuller Tamir +2 more
doaj +1 more source
Maize Anther Development Involves Translated Open Reading Frames From 3′ Untranslated Regions
Advanced Science, EarlyView.This study examined the translation activity across ten stages of maize anther development, integrating transcriptome and small‐peptide data. It linked mutations in translated 3' ORFs to anther sterility, exemplified by Zm00001eb417050_3' ORF (known as APV1). In addition, the data indicated that maize anthers could assimilate CO2 through the stomata in
Chunyu Wang +8 more
wiley +1 more source
Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP
Nature Communications, 2019 The Staufen proteins recognize secondary structures in 3’-untranslated regions in mRNA transcripts and induce degradation of these mRNAs with the help of the RNA helicase UPF1.
Manjeera Gowravaram +4 more
doaj +1 more source