Results 161 to 170 of about 2,786,263 (356)

LGP2 plays a critical role in sensitizing mda-5 to activation by double-stranded RNA.

, 2013
The DExD/H box RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation associated gene-5 (mda-5) sense viral RNA in the cytoplasm of infected cells and activate signal transduction pathways that trigger the production of type I ...
Kay S Childs, Richard E. Randall (190211), Randall, RE, Stephen Goodbourn (411674), Goodbourn, Stephen, Kay S. Childs (411673), Richard E. R, Goodbourn, S, Childs, Kay S., Childs Kay S., Richard E Randall, Randall Richard E., Randall, Richard E., Kay S. Childs, Stephen Goodbourn, Childs, KS, Goodbourn Stephen   +16 more
core   +1 more source

Functional organization of cytoplasmic inclusion bodies in cells infected by respiratory syncytial virus

Nature Communications, 2017
Respiratory syncytial virus (RSV) induces formation of inclusion bodies (IBs) sheltering viral RNA synthesis. Here, Rincheval et al. identify highly dynamic IB-associated granules (IBAGs) that accumulate newly synthetized viral mRNA and the viral M2-1 ...
Vincent Rincheval, Mickael Lelek, Elyanne Gault, Camille Bouillier, Delphine Sitterlin, Sabine Blouquit-Laye, Marie Galloux, Christophe Zimmer, Jean-François Eleouet, Marie-Anne Rameix-Welti   +9 more
doaj   +1 more source

Identification of a Natural Viral RNA Motif That Optimizes Sensing of Viral RNA by RIG-I

mBio, 2015
Stimulation of the antiviral response depends on the sensing of viral pathogen-associated molecular patterns (PAMPs) by specialized cellular proteins.
Jie Xu, Xiomara Mercado-López, Jennifer T. Grier, Won-keun Kim, Lauren F. Chun, Edward B. Irvine, Yoandris Del Toro Duany, Alison Kell, Sun Hur, Michael Gale, Arjun Raj, Carolina B. López   +11 more
doaj   +1 more source

Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis

EMBO Journal, 2017
Nucleic acids are potent triggers for innate immunity. Double‐stranded DNA and RNA adopt different helical conformations, including the unusual Z‐conformation.
J. Maelfait, L. Liverpool, A. Bridgeman, Katherine B. Ragan, J. Upton, J. Rehwinkel   +5 more
semanticscholar   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Packaging of viral RNAs in virions of adenoviruses

Virology Journal, 2009
Earlier, we detected viral RNAs packaged in the porcine adenovirus (PAdV) -3 virions. Using Southern blot analysis, we further demonstrated that the viral RNAs were predominantly packaged in CsCl purified mature capsids (containing viral genome) than ...
Xing Li, Tikoo Suresh K
doaj   +1 more source

N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection

Cell Host and Microbe, 2016
Summary The RNA modification N6-methyladenosine (m6A) post-transcriptionally regulates RNA function. The cellular machinery that controls m6A includes methyltransferases and demethylases that add or remove this modification, as well as m6A-binding YTHDF ...
Nandan S. Gokhale, Alexa B. R. McIntyre, M. J. McFadden, A. Roder, E. M. Kennedy, J. Gandara, S. Hopcraft, K. Quicke, Christine Vazquez, J. Willer, O. Ilkayeva, Brittany A. Law, C. Holley, M. Garcia-Blanco, M. Evans, M. Suthar, Shelton Bradrick, C. Mason, Stacy M. Horner   +18 more
semanticscholar   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

The consequences of reconfiguring the ambisense S genome segment of Rift Valley fever virus on viral replication in mammalian and mosquito cells and for genome packaging [PDF]

, 2013
Rift Valley fever virus (RVFV, family Bunyaviridae) is a mosquito-borne pathogen of both livestock and humans, found primarily in Sub-Saharan Africa and the Arabian Peninsula.
Benjamin Brennan (522804), Brennan, Benjamin, Richard M. Elliott, Richard M Elliott, Welch Stephen R., Elliott, Richard M., Benjamin Brennan, Elliott Richard M., Richard M. Elliott (252934), Stephen R Welch, Stephen R. Welch (522805), Stephen R. Welch, Welch, Stephen R., Brennan Benjamin   +13 more
core   +1 more source

Dynamics of the human and viral m6A RNA methylomes during HIV-1 infection of T cells

Nature Microbiology, 2016
N6-methyladenosine (m6A) is the most prevalent internal modification of eukaryotic mRNA. Very little is known of the function of m6A in the immune system or its role in host–pathogen interactions.
Gianluigi Lichinchi, Shang Gao, Yogesh Saletore, G. Gonzalez, V. Bansal, Yinsheng Wang, C. Mason, T. Rana   +7 more
semanticscholar   +1 more source