Results 171 to 180 of about 1,114,234 (207)
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Relationship between viral RNA and viral protein synthesis
Virology, 1962Abstract Low concentrations of p-fluorophenylalanine (5–10 μg/ml) inhibit the maturation of Western equine encephalomyelitis and poliomyelitis viruses. Much higher concentrations are required (125 μg/ml) to inhibit the synthesis of the respective infectious RNA. By means of fluorescent antibodies against poliovirus, it was found that the formation of
E, WECKER, K, HUMMELER, O, GOETZ
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Nature Chemical Biology, 2005
Retroviruses have a stretch of RNA that dimerizes during viral particle formation. A new study suggests that RNA flexibility in the monomeric form may facilitate dimerization or other RNA-dependent viral functions.
Valerie Calabro, Alan D Frankel
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Retroviruses have a stretch of RNA that dimerizes during viral particle formation. A new study suggests that RNA flexibility in the monomeric form may facilitate dimerization or other RNA-dependent viral functions.
Valerie Calabro, Alan D Frankel
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Viral suppressors of RNA silencing
Current Opinion in Biotechnology, 2001The suppression of RNA silencing by plant viruses represents a viral adaptation to a novel host antiviral defense. Three types of viral suppressors have been identified through the use of a variety of silencing suppression assays. The first two types of suppressor are capable of a complete or partial reversal of pre-existing RNA silencing; the third ...
W X, Li, S W, Ding
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1969
Publisher Summary The pace of research on RNA virus replication and the huge amount of related literature that has accumulated in the past 6 years attest to the wide interest in the topic. There has also been some controversy and apparent confusion, probably largely because of pressure for publication priority. In this chapter, methods for detecting,
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Publisher Summary The pace of research on RNA virus replication and the huge amount of related literature that has accumulated in the past 6 years attest to the wide interest in the topic. There has also been some controversy and apparent confusion, probably largely because of pressure for publication priority. In this chapter, methods for detecting,
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Viral suppressors of RNA silencing
Trends in Plant Science, 2011The infection and replication of viruses in the host induce diverse mechanisms for combating viral infection. One of the best-studied antiviral defence mechanisms is based on RNA silencing. Consistently, several viral suppressors of RNA silencing (VSRs) have been identified from almost all plant virus genera, which are surprisingly diverse within and ...
József, Burgyán, Zoltán, Havelda
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Viral vector-mediated RNA interference
Current Opinion in Pharmacology, 2010RNA interference (RNAi) is a powerful gene silencing mechanism that if properly harnessed has the potential to revolutionize medical interventions. Delivery of inhibitory RNAs to target tissues needs to be safe, efficient, and for many diseases, long-lasting, in order to exploit this endogenous mechanism for therapeutic purposes.
Linda B, Couto, Katherine A, High
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2014
This chapter summarizes what is known about how a single viral RNA molecule can be selectively amplified into thousands of RNA progeny in infected cells. It specifically provides the roles of viral proteins and RNA sequences in RNA replication, and describes the kinetics and products of RNA replication in infected cells. Next, it explains the sites and
Kyle L. Johnson, Peter Sarnow
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This chapter summarizes what is known about how a single viral RNA molecule can be selectively amplified into thousands of RNA progeny in infected cells. It specifically provides the roles of viral proteins and RNA sequences in RNA replication, and describes the kinetics and products of RNA replication in infected cells. Next, it explains the sites and
Kyle L. Johnson, Peter Sarnow
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Structural organization of viral RNA-dependent RNA polymerases
Biochemistry (Moscow), 2013This review describes available data on the structure of viral RNA-dependent RNA polymerases (RdRP) obtained from X-ray analysis and discusses the functional significance of the structural elements of these enzymes. Because most of the studies done to date relate to RdRP structures of picorna-, flavi-, and caliciviruses, here we consider mostly the ...
G S, Shatskaya, T M, Dmitrieva
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RNA interference – small RNAs effectively fight viral hepatitis
Liver International, 2004Abstract: RNA interference (RNAi) is the process of sequence‐specific gene silencing, initiated by double‐stranded RNA that is homologous in sequence to the target gene. This unique phenomenon has been extensively investigated during the last few years not only in the context of its mechanism and its possible role in the regulation of gene expression ...
Amir, Shlomai, Yosef, Shaul
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Viral RNA-Dependent RNA Polymerases: A Structural Overview
2018Most emerging and re-emerging human and animal viral diseases are associated with RNA viruses. All these pathogens, with the exception of retroviruses, encode a specialized enzyme called RNA-dependent RNA polymerase (RdRP), which catalyze phosphodiester-bond formation between ribonucleotides (NTPs) in an RNA template-dependent manner.
Diego, Ferrero +2 more
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