Results 221 to 230 of about 870,257 (232)
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Studies in the replication of viral RNA
Journal of Cellular Physiology, 1967Experiments will be described which demonstrate that the product of purified “Qβ-replicase” is fully competent to serve both as a template and as a program for the synthesis of complete virus particles. The use of mutant RNA has permitted the demonstration that nucleic acid is the instructive agent in the replication process and hence satisfies the ...
D. R. Mills +6 more
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1985
In the cytoplasm of an uninfected mammalian host cell, so far no enzymes have been detected that synthesize RNA on an RNA template. The incoming poliovirus contains a plus strand RNA but does not carry an RNA-replicase. Formation of replicase(s) is a prerequisite for the synthesis of viral progeny RNA.
Friedrich Koch, Gebhard Koch
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In the cytoplasm of an uninfected mammalian host cell, so far no enzymes have been detected that synthesize RNA on an RNA template. The incoming poliovirus contains a plus strand RNA but does not carry an RNA-replicase. Formation of replicase(s) is a prerequisite for the synthesis of viral progeny RNA.
Friedrich Koch, Gebhard Koch
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2014
This chapter summarizes what is known about how a single viral RNA molecule can be selectively amplified into thousands of RNA progeny in infected cells. It specifically provides the roles of viral proteins and RNA sequences in RNA replication, and describes the kinetics and products of RNA replication in infected cells. Next, it explains the sites and
Peter Sarnow, Kyle L. Johnson
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This chapter summarizes what is known about how a single viral RNA molecule can be selectively amplified into thousands of RNA progeny in infected cells. It specifically provides the roles of viral proteins and RNA sequences in RNA replication, and describes the kinetics and products of RNA replication in infected cells. Next, it explains the sites and
Peter Sarnow, Kyle L. Johnson
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Science, 2007
Human cytomegalovirus expresses noncoding RNAs that repress host immune responses during infection.
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Human cytomegalovirus expresses noncoding RNAs that repress host immune responses during infection.
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Viral Small RNA Cloning and Sequencing
2011At the current rate of technological progress, high-throughput sequencing of nucleic acids has become a commodity. These techniques are perfectly suitable for viral small RNAs sequencing and contribute to the understanding of many aspects of virus biology in the context of host-pathogen interaction. However, the generation of high quality data is still
Gausson, Valérie, Saleh, Maria-Carla
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Relationship between viral RNA and viral protein synthesis
Virology, 1962Abstract Low concentrations of p-fluorophenylalanine (5–10 μg/ml) inhibit the maturation of Western equine encephalomyelitis and poliomyelitis viruses. Much higher concentrations are required (125 μg/ml) to inhibit the synthesis of the respective infectious RNA. By means of fluorescent antibodies against poliovirus, it was found that the formation of
Otmar Goetz +3 more
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1969
Publisher Summary The pace of research on RNA virus replication and the huge amount of related literature that has accumulated in the past 6 years attest to the wide interest in the topic. There has also been some controversy and apparent confusion, probably largely because of pressure for publication priority. In this chapter, methods for detecting,
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Publisher Summary The pace of research on RNA virus replication and the huge amount of related literature that has accumulated in the past 6 years attest to the wide interest in the topic. There has also been some controversy and apparent confusion, probably largely because of pressure for publication priority. In this chapter, methods for detecting,
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Electron Microscopy of Viral RNA
1981The electron microscopy of nucleic acid molecules has become a routine tool in the analysis of genome structure and function. This is primarily due to the availability of simple reliable methods for the visualization of single- and double-stranded DNA and RNA molecules, of RNA-DNA hybrids, and of nucleic acid-protein complexes.
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Interaction of formate esters with viral RNA and viral polymerase
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971Abstract Esters of chloroformic acid inactivate the infectivity of single-stranded poliovirus RNA, but not that of the double-stranded replicative form. Diethyl pyrocarbonate, a similar structure does not inactivate the infectivity of the replicative form nor that of the replicative intermediate.
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, 1977