Results 201 to 210 of about 8,817,235 (253)

Myostatin/Smad3 in Spinal Muscular Atrophy: Biomarkers of Disease Severity and Treatment Response

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Given the role of Myostatin (MSTN) in muscle homeostasis and its modulation by current spinal muscular atrophy (SMA) therapies, we investigated serum MSTN and, for the first time, its downstream effector Smad3 as candidate non‐invasive biomarkers in SMA patients undergoing disease‐modifying therapies (DMTs).
Giorgia Riolo, Claudia Dosi, Stefano Parravicini, Riccardo Zanin, Marta Cheli, Eleonora Giacopuzzi Grigoli, Amalia Canciello, Francesca Andreetta, Riccardo Masson, Silvia Bonanno, Stefania Marcuzzo, Lorenzo Maggi   +11 more
wiley   +1 more source

Mapping RNA-protein interactions with subcellular resolution using colocalization CLIP. [PDF]

RNA
Yi S, Singh SS, Rozen-Gagnon K, Luna JM.
europepmc   +1 more source

Determinants of Body Mass Index in Early Systemic Sclerosis: Implications for Nutritional Risk Stratification

Arthritis Care &Research, EarlyView.
Objective Gastrointestinal (GI) involvement can lead to malnutrition in patients with systemic sclerosis (SSc). Body mass index (BMI) remains the most widely used marker to screen nutritional status. We aimed to identify predictors of lower BMI in patients with SSc. Methods Patients with SSc from a prospective US cohort meeting 2013 American College of
Ali Y. Ayla, Meng Zhang, Bingrui Chen, Claudia Pedroza, Brian Skaug, Maureen Mayes, Michael Hughes, Shervin Assassi, Zsuzsanna H. McMahan   +8 more
wiley   +1 more source

Understanding species-specific and conserved RNA-protein interactions in vivo and in vitro. [PDF]

Nat Commun
Harris SE, Alexis MS, Giri G, Cavazos FF, Hu Y, Murn J, Aleman MM, Burge CB, Dominguez D.   +8 more
europepmc   +1 more source

Association of Elevated Platelets and C‐Reactive Protein With Severe Disease and Poor Survival in Systemic Sclerosis

Arthritis Care &Research, EarlyView.
Objective Elevated C‐reactive protein (CRP) levels in systemic sclerosis (SSc) have been linked with severe disease and worse survival, but the role of platelet levels remains unclear. This study examined whether elevated platelet levels, CRP levels, or both are associated with disease severity, progression, and survival in SSc.
Brian S. Lee, Shufeng Li, Srijana Davuluri, Jennifer Lee, Lorinda Chung   +4 more
wiley   +1 more source

Probing RNA-protein interactions in the early mouse embryo

Bora P, Rando OJ.
europepmc   +1 more source

MFH-LPI: based on multi-view similarity networks fusion and hypergraph learning for long non-coding RNA-protein interactions prediction. [PDF]

BMC Genomics
Xing Z, Yu S, Liao S, Wang P, Liao B.
europepmc   +1 more source

Oral glucocorticoids added to ILD‐modifying therapy in systemic sclerosis‐associated interstitial lung disease: a target trial emulation study from the EUSTAR database.

Arthritis Care &Research, Accepted Article.
Objectives We aimed to estimate whether adding oral glucocorticoids to ILD‐modifying therapy improves 12‐month lung outcomes in systemic sclerosis‐associated interstitial lung disease (SSc‐ILD). Methods We emulated a target trial using the EUSTAR database.
Zubeyir Salis, Simona Truglia, Oliver Distler, Gábor Kumánovics, Gianluca Moroncini, David Launay, Silvia Bellando‐Randone, Gonçalo Boleto, Nicoletta Del Papa, Ana Maria Gheorghiu, Duygu Temiz Karadag, Zguro Batalov, Gabriella Szucs, Michele Iudici, The EUSTAR collaborators   +14 more
wiley   +1 more source

Stability-Based Proteomics for Investigation of Structured RNA-Protein Interactions. [PDF]

Anal Chem
Bailey MA, Martyr JG, Hargrove AE, Fitzgerald MC.   +3 more
europepmc   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source