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Uncovering Novel Viral Innate Immune Evasion Strategies: What Has SARS-CoV-2 Taught Us?
The ongoing SARS-CoV-2 pandemic has tested the capabilities of public health and scientific community. Since the dawn of the twenty-first century, viruses have caused several outbreaks, with coronaviruses being responsible for 2: SARS-CoV in 2007 and ...
Douglas Jie Wen Tay +12 more
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Asian Zika virus can acquire generic African-lineage mutations during in utero infection
The Zika virus 2015 epidemic showed an unusual phenotype for human flaviviruses, specifically fetal infection. We previously showed that in utero inoculation with the Asian Zika virus isolated from the human sample causes persistent infection in porcine ...
Ahmad Jawad Sabir +4 more
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Emerging Role of Circular RNA–Protein Interactions
Circular RNAs (circRNAs) are emerging as novel regulators of gene expression in various biological processes. CircRNAs regulate gene expression by interacting with cellular regulators such as microRNAs and RNA binding proteins (RBPs) to regulate ...
Arundhati Das +3 more
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In bacterial cells we find a variety of interacting macromolecules, among them RNAs and proteins. Not only small regulatory RNAs (sRNAs), but also small proteins have been increasingly recognized as regulators of bacterial gene expression.
Inam Ul Haq +2 more
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Template-Based Modeling of Protein-RNA Interactions. [PDF]
Protein-RNA complexes formed by specific recognition between RNA and RNA-binding proteins play an important role in biological processes. More than a thousand of such proteins in human are curated and many novel RNA-binding proteins are to be discovered.
Jinfang Zheng +3 more
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Computational tools to study RNA-protein complexes
RNA is the key player in many cellular processes such as signal transduction, replication, transport, cell division, transcription, and translation. These diverse functions are accomplished through interactions of RNA with proteins.
Sneha Bheemireddy +5 more
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RNA Proximity Labeling: A New Detection Tool for RNA–Protein Interactions
Multiple cellular functions are controlled by the interaction of RNAs and proteins. Together with the RNAs they control, RNA interacting proteins form RNA protein complexes, which are considered to serve as the true regulatory units for post ...
Ronja Weissinger +4 more
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Essential Assembly Factor Rpf2 Forms Novel Interactions within the 5S RNP in
Ribosome biogenesis is a highly complex and conserved cellular process that is responsible for making ribosomes. During this process, there are several assembly steps that function as regulators to ensure proper ribosome formation.
Anyango D. Kamina +3 more
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Use of RNA affinity chromatography is commonly used to identify RNA binding proteins that interact with specific RNA cis-elements that function in post-transcriptional gene regulation.
Ruben H. Hovhannisyan, Russ P. Carstens
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Proteomic profiling of RNA-binding proteins in Leishmania is currently limited to polyadenylated mRNA-binding proteins, leaving proteins that interact with nonadenylated RNAs, including noncoding RNAs and pre-mRNAs, unidentified.
Karunakaran Kalesh +5 more
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