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Decoding RNA–protein interactions using high-throughput methods [PDF]
RNA BiologyRNA-binding proteins (RBPs) constitute a diverse class of proteins essential for every stage of the gene expression process. Many RBPs are also linked to human diseases and pathologies.
Marianne Régis +2 more
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Emerging Role of Circular RNA–Protein Interactions [PDF]
Non-Coding RNA, 2021 Circular RNAs (circRNAs) are emerging as novel regulators of gene expression in various biological processes. CircRNAs regulate gene expression by interacting with cellular regulators such as microRNAs and RNA binding proteins (RBPs) to regulate ...
Arundhati Das +3 more
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Specificity and nonspecificity in RNA–protein interactions [PDF]
Nature Reviews Molecular Cell Biology, 2015 To fully understand the regulation of gene expression, it is critical to quantitatively define whether and how RNA-binding proteins (RBPs) discriminate between alternative binding sites in RNAs. Here, we describe new methods that measure protein binding to large numbers of RNA variants, and ways to analyse and interpret data obtained by these ...
Eckhard Jankowsky +2 more
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Interplay between RNA‐protein interactions and RNA structures in gene regulation [PDF]
FEBS Open BioCellular RNAs are not linear single‐stranded stretches of nucleic acids as depicted in textbook cartoons but fold into secondary and tertiary structures through intra‐ and intermolecular base‐pairing.
Jenni Rapakko +2 more
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Temporal-iCLIP captures co-transcriptional RNA-protein interactions [PDF]
Nature Communications, 2023 Dynamic RNA-protein interactions govern the co-transcriptional packaging of RNA polymerase II derived transcripts. Here the authors use temporal-iCLIP which combines transcriptional synchronisation with UV cross-linking of RNA-protein complexes to reveal
Ross A. Cordiner +5 more
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Viral RNA Interactome: The Ultimate Researcher’s Guide to RNA–Protein Interactions [PDF]
VirusesRNA molecules in the cell are bound by a multitude of RNA-binding proteins (RBPs) with a variety of regulatory consequences. Often, interactions with these RNA-binding proteins are facilitated by the complex secondary and tertiary structures of RNA ...
Wesley A. Hanson +2 more
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PaRPI predicts RNA-Protein interactions from cross-protocol and cross-batch RNA-binding protein datasets [PDF]
Communications BiologyRNA-binding proteins (RBPs) play a pivotal role in the regulation of gene expression, with their interactions with RNA reflecting the biological functions and regulatory mechanisms.
Liangchen Peng +11 more
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Uncovering Novel Viral Innate Immune Evasion Strategies: What Has SARS-CoV-2 Taught Us?
Frontiers in Microbiology, 2022 The ongoing SARS-CoV-2 pandemic has tested the capabilities of public health and scientific community. Since the dawn of the twenty-first century, viruses have caused several outbreaks, with coronaviruses being responsible for 2: SARS-CoV in 2007 and ...
Douglas Jie Wen Tay +12 more
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Asian Zika virus can acquire generic African-lineage mutations during in utero infection
Emerging Microbes and Infections, 2023 The Zika virus 2015 epidemic showed an unusual phenotype for human flaviviruses, specifically fetal infection. We previously showed that in utero inoculation with the Asian Zika virus isolated from the human sample causes persistent infection in porcine ...
Ahmad Jawad Sabir +4 more
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'Oming in on RNA–protein interactions [PDF]
Genome Biology, 2014 Welcome to the RBPome RNA has consistently broken dogmas, owing to its multitude of unexpected functions. However, RNA does faithfully adhere to one rule: it always functions through interactions with proteins. The studies in this issue focus on the rapidly expanding repertoire of diverse RNA– protein interactions [1] and their functional roles and ...
Rinn, John L, Ule, Jernej
openaire +2 more sources