Results 21 to 30 of about 798,183 (256)
RNA Protein Interaction in Neurons [PDF]
Annual Review of Neuroscience, 2013 Neurons have their own systems for regulating RNA. Several multigene families encode RNA binding proteins (RNABPs) that are uniquely expressed in neurons, including the well-known neuron-specific markers ELAV and NeuN and the disease antigen NOVA. New technologies have emerged in recent years to assess the function of these proteins in vivo, and the ...
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Methods to study RNA–protein interactions [PDF]
Nature Methods, 2019 Noncoding RNA sequences, including long noncoding RNAs, small nucleolar RNAs, and untranslated mRNA regions, accomplish many of their diverse functions through direct interactions with RNA-binding proteins (RBPs). Recent efforts have identified hundreds of new RBPs that lack known RNA-binding domains, thus underscoring the complexity and diversity of ...
Muthukumar Ramanathan +2 more
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Identification of proteins binding coding and non-coding human RNAs using protein microarrays
BMC Genomics, 2012 Background The regulation and function of mammalian RNAs has been increasingly appreciated to operate via RNA-protein interactions. With the recent discovery of thousands of novel human RNA molecules by high-throughput RNA sequencing, efficient methods ...
Siprashvili Zurab +6 more
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DEAD-Box Helicases: Sensors, Regulators, and Effectors for Antiviral Defense
Viruses, 2020 DEAD-box helicases are a large family of conserved RNA-binding proteins that belong to the broader group of cellular DExD/H helicases. Members of the DEAD-box helicase family have roles throughout cellular RNA metabolism from biogenesis to decay ...
Frances Taschuk, Sara Cherry
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iScience, 2022 Summary: RNA localization and biomolecular condensate formation are key biological strategies for organizing the cytoplasm and generating cellular polarity. In Xenopus oocytes, RNAs required for germ layer patterning localize in biomolecular condensates,
Sarah E. Cabral +2 more
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Transient RNA–protein interactions in RNA folding [PDF]
The FEBS Journal, 2011 The RNA folding trajectory features numerous off‐pathway folding traps, which represent conformations that are often equally as stable as the native functional ones. Therefore, the conversion between these off‐pathway structures and the native correctly folded ones is the critical step in RNA folding. This process, referred to as RNA refolding, is slow,
Dötsch, Martina +2 more
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Probing Long Non-coding RNA-Protein Interactions
Frontiers in Molecular Biosciences, 2017 Non-coding RNA sequences outnumber the protein-coding genes in the human genome, however our knowledge of their functions is still limited. RNA-binding proteins follow the transcripts, including non-coding RNAs, throughout their life, regulating not only
Jasmine Barra +2 more
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Compendium of Methods to Uncover RNA-Protein Interactions In Vivo
Methods and Protocols, 2021 Control of gene expression is critical in shaping the pro-and eukaryotic organisms’ genotype and phenotype. The gene expression regulatory pathways solely rely on protein–protein and protein–nucleic acid interactions, which determine the fate of the ...
Mrinmoyee Majumder +1 more
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mSphere, 2019 Ribosomal maturation is a complex and highly conserved biological process involving migration of a continuously changing RNP across multiple cellular compartments.
Constance Rink +2 more
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Testing ancient RNA–protein interactions [PDF]
Proceedings of the National Academy of Sciences, 1999 The past decade in molecular biology has seen remarkable advances in the study of the origin and early evolution of life. The mathematical tools for analyzing DNA and protein sequences, coupled with the availability of complete microbial genome sequences, provide insight almost as far back as the age of the nucleic acids themselves ...
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