Results 101 to 110 of about 2,650,407 (299)

RNA packaging into extracellular vesicles: An orchestra of RNA‐binding proteins?

Journal of Extracellular Vesicles, 2020
Extracellular vesicles (EVs) are heterogeneous membranous particles released from the cells through different biogenetic and secretory mechanisms. We now conceive EVs as shuttles mediating cellular communication, carrying a variety of molecules resulting
Fabrizio Fabbiano, J. Corsi, E. Gurrieri, C. Trevisan, M. Notarangelo, V. D’Agostino   +5 more
semanticscholar   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Data of protein-RNA binding sites

Data in Brief, 2017
Despite the increasing number of protein-RNA complexes in structure databases, few data resources have been made available which can be readily used in developing or testing a method for predicting either protein-binding sites in RNA sequences or RNA-binding sites in protein sequences. The problem of predicting protein-binding sites in RNA has received
Wook Lee, Byungkyu Park, Daesik Choi, Kyungsook Han   +3 more
openaire   +3 more sources

mSphere of Influence: Modifying an Old Method To Study RNA-Protein Interactions

mSphere, 2019
Calvin Tiengwe works on posttranscriptional gene regulation and iron homeostasis in the parasitic protozoan Trypanosoma brucei. In this mSphere of Influence article, he reflects on how the paper “Comprehensive identification of RNA-protein interactions ...
Calvin Tiengwe
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Induced ncRNAs Allosterically Modify RNA Binding Proteins in cis to Inhibit Transcription

Nature, 2008
With the recent recognition of non-coding RNAs (ncRNAs) flanking many genes, a central issue is to obtain a full understanding of their potential roles in regulated gene transcription programmes, possibly through different mechanisms.
Xiangting Wang, S. Arai, Xiaoyuan Song, D. Reichart, K. Du, G. Pascual, P. Tempst, M. Rosenfeld, C. Glass, R. Kurokawa   +9 more
semanticscholar   +1 more source

Binding specificities of human RNA-binding proteins toward structured and linear RNA sequences

Genome Research, 2020
RNA-binding proteins (RBPs) regulate RNA metabolism at multiple levels by affecting splicing of nascent transcripts, RNA folding, base modification, transport, localization, translation, and stability.
A. Jolma, Jilin Zhang, E. Mondragón, E. Morgunova, Teemu Kivioja, Kaitlin U. Laverty, Yimeng Yin, F. Zhu, G. Bourenkov, Q. Morris, T. Hughes, L. Maher, J. Taipale   +12 more
semanticscholar   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Versatility of RNA-Binding Proteins in Cancer [PDF]

Comparative and Functional Genomics, 2012
Posttranscriptional gene regulation is a rapid and efficient process to adjust the proteome of a cell to a changing environment. RNA-binding proteins (RBPs) are the master regulators of mRNA processing and translation and are often aberrantly expressed in cancer.
openaire   +2 more sources