Results 111 to 120 of about 1,640,882 (289)

Novel domains in the hnRNP G/RBMX protein with distinct roles in RNA binding and targeting nascent transcripts [PDF]

, 2010
Rasha Kanhoush, Brent Beenders, Caroline Perrin, Jacques Moreau, Michel Bellini, May Penrad‐Mobayed   +5 more
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Predicting nuclear G-quadruplex RNA-binding proteins with roles in transcription and phase separation

Nature Communications
RNA-binding proteins are central for many biological processes and their characterization has demonstrated a broad range of functions as well as a wide spectrum of target structures.
Johanna Luige, Alexandros Armaos, Gian Gaetano Tartaglia, Ulf Andersson Vang Ørom   +3 more
doaj   +1 more source

RNA binding proteins in cancer chemotherapeutic drug resistance

Frontiers in Cell and Developmental Biology
Drug resistance has been a major obstacle in the quest for a cancer cure. Many chemotherapeutic treatments fail to overcome chemoresistance, resulting in tumor remission.
Hemanathan Vembuli, Hemanathan Vembuli, Ravi Gor, Satish Ramalingam, Selene Perales, Johnson Rajasingh, Johnson Rajasingh, Johnson Rajasingh   +7 more
doaj   +1 more source

A Combined Mass Spectrometry and Data Integration Approach to Predict the Mitochondrial Poly(A) RNA Interacting Proteome

Frontiers in Cell and Developmental Biology, 2019
In order to synthesize the 13 oxidative phosphorylation proteins encoded by mammalian mtDNA, a large assortment of nuclear encoded proteins is required. These include mitoribosomal proteins and various RNA processing, modification and degradation enzymes.
Selma L. van Esveld, Şirin Cansız-Arda, Fenna Hensen, Robin van der Lee, Martijn A. Huynen, Johannes N. Spelbrink   +5 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Extracellular Vesicles: Tiny Messengers for Mighty RNA Delivery

Biologics
Extracellular vesicles (EVs) encompass a diverse array of cell-derived vesicles, originating either from the endosomal compartment (exosomes) or generated through shedding from the cell membrane.
Alakesh Das
doaj   +1 more source

Association of Zinc Finger Antiviral Protein Binding to Viral Genomic RNA with Attenuation of Replication of Echovirus 7

, 2021
Niluka Goonawardane, Dung Nguyen, Peter Simmonds   +2 more
openalex   +1 more source

RNA-binding Protein MBNL2 regulates Cancer Cell Metastasis through MiR-182-MBNL2-AKT Pathway [PDF]

, 2021
Guanglan Lin, Jiao Li, Jin Cai, Haowei Zhang, Qilei Xin, Ningchao Wang, Weidong Xie, Yaou Zhang, Naihan Xu   +8 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source